Undernutrition increased the risk of loss to follow-up among adults living with HIV on ART in Northwest Ethiopia: a retrospective cohort study.

Alebel, A; Sibbritt, D; Petrucka, P; Demant, D

Undernutrition increased the risk of loss to follow-up among adults living with HIV on ART in Northwest Ethiopia: a retrospective cohort study.

Alebel, A Sibbritt, D

Petrucka, P Demant, D

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Sci Rep, 2022, 12, (1), pp. 22556
Issue Date:: 2022-12-29

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Field	Value	Language
dc.contributor.author	Alebel, A
dc.contributor.author	Sibbritt, D https://orcid.org/0000-0003-3561-9447
dc.contributor.author	Petrucka, P
dc.contributor.author	Demant, D https://orcid.org/0000-0003-3330-2972
dc.date.accessioned	2023-01-25T03:04:04Z
dc.date.available	2022-12-26
dc.date.available	2023-01-25T03:04:04Z
dc.date.issued	2022-12-29
dc.identifier.citation	Sci Rep, 2022, 12, (1), pp. 22556
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/165427
dc.description.abstract	This study aims to examine the effect of undernutrition on loss to follow-up (LTFU) in adults living with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART) in Ethiopia. We conducted an institution-based retrospective cohort study using medical records of 844 adults living with HIV receiving ART between June 2014 and June 2020 at Debre Markos Comprehensive Specialized Hospital (Northwest Ethiopia). The effect of undernutrition on LTFU was examined using a proportional hazards regression model after adjusting potential confounders. The significance level was set at p < 0.05. At the end of the study period, 109 (12.9%) participants were considered LTFU, with an overall LTFU incidence of 5.3 per 100 person-years (95% CI 4.4, 6.4). The incidence of LTFU was higher in undernourished participants (8.2 per 100 person-years) compared to well-nourished participants (4.3 per 100 person-years). After adjusting for potential confounders, the adjusted risk of LTFU among undernourished participants was two times higher than in their well-nourished counterparts (AHR [adjusted hazard ratio]: 2.1, 95% CI 1.4, 3.2). This study found that undernutrition significantly increased the risk of LTFU among adults living with HIV on ART.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Sci Rep
dc.relation.isbasedon	10.1038/s41598-022-27077-y
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Adult
dc.subject.mesh	Humans
dc.subject.mesh	Ethiopia
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	HIV
dc.subject.mesh	HIV Infections
dc.subject.mesh	Malnutrition
dc.subject.mesh	Proportional Hazards Models
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Lost to Follow-Up
dc.subject.mesh	Antiretroviral Therapy, Highly Active
dc.subject.mesh	Humans
dc.subject.mesh	HIV
dc.subject.mesh	HIV Infections
dc.subject.mesh	Malnutrition
dc.subject.mesh	Antiretroviral Therapy, Highly Active
dc.subject.mesh	Proportional Hazards Models
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Adult
dc.subject.mesh	Ethiopia
dc.subject.mesh	Lost to Follow-Up
dc.title	Undernutrition increased the risk of loss to follow-up among adults living with HIV on ART in Northwest Ethiopia: a retrospective cohort study.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Strength - ARCCIM - Australian Research Centre in Complementary & Integrative Medicine
utslib.copyright.status	open_access	*
dc.date.updated	2023-01-25T03:03:41Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	12
utslib.citation.issue	1

Abstract:

This study aims to examine the effect of undernutrition on loss to follow-up (LTFU) in adults living with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART) in Ethiopia. We conducted an institution-based retrospective cohort study using medical records of 844 adults living with HIV receiving ART between June 2014 and June 2020 at Debre Markos Comprehensive Specialized Hospital (Northwest Ethiopia). The effect of undernutrition on LTFU was examined using a proportional hazards regression model after adjusting potential confounders. The significance level was set at p < 0.05. At the end of the study period, 109 (12.9%) participants were considered LTFU, with an overall LTFU incidence of 5.3 per 100 person-years (95% CI 4.4, 6.4). The incidence of LTFU was higher in undernourished participants (8.2 per 100 person-years) compared to well-nourished participants (4.3 per 100 person-years). After adjusting for potential confounders, the adjusted risk of LTFU among undernourished participants was two times higher than in their well-nourished counterparts (AHR [adjusted hazard ratio]: 2.1, 95% CI 1.4, 3.2). This study found that undernutrition significantly increased the risk of LTFU among adults living with HIV on ART.

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http://hdl.handle.net/10453/165427