"Living like an empty gas tank with a leak": Mixed methods study on post-acute sequelae of COVID-19.

Ogungbe, O; Slone, S; Alharthi, A; Tomiwa, T; Kumbe, B; Bergman, A; McNabb, K; Smith Wright, R; Farley, JE; Dennison Himmelfarb, CR; Cooper, LA; Post, WS; Davidson, PM; Commodore-Mensah, Y

"Living like an empty gas tank with a leak": Mixed methods study on post-acute sequelae of COVID-19.

Ogungbe, O Slone, S Alharthi, A Tomiwa, T Kumbe, B Bergman, A McNabb, K Smith Wright, R Farley, JE Dennison Himmelfarb, CR Cooper, LA Post, WS Davidson, PM Commodore-Mensah, Y

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Publisher:: Public Library of Science (PLoS)
Publication Type:: Journal Article
Citation:: PLoS One, 2022, 17, (12), pp. e0279684
Issue Date:: 2022

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Field	Value	Language
dc.contributor.author	Ogungbe, O
dc.contributor.author	Slone, S
dc.contributor.author	Alharthi, A
dc.contributor.author	Tomiwa, T
dc.contributor.author	Kumbe, B
dc.contributor.author	Bergman, A
dc.contributor.author	McNabb, K
dc.contributor.author	Smith Wright, R
dc.contributor.author	Farley, JE
dc.contributor.author	Dennison Himmelfarb, CR
dc.contributor.author	Cooper, LA
dc.contributor.author	Post, WS
dc.contributor.author	Davidson, PM
dc.contributor.author	Commodore-Mensah, Y
dc.contributor.editor	Kumar, S
dc.date.accessioned	2023-02-10T00:52:38Z
dc.date.available	2022-12-12
dc.date.available	2023-02-10T00:52:38Z
dc.date.issued	2022
dc.identifier.citation	PLoS One, 2022, 17, (12), pp. e0279684
dc.identifier.issn	1932-6203
dc.identifier.issn	1932-6203
dc.identifier.uri	http://hdl.handle.net/10453/166026
dc.description.abstract	BACKGROUND: The burden and presentation of post-acute sequela of SARS-CoV-2 infection (PASC) are a developing major public health concern. OBJECTIVES: To characterize the burden of PASC in community-dwelling individuals and understand the experiences of people living with PASC. METHODS: This mixed-methods study of COVID-19 positive community-dwelling persons involved surveys and in-depth interviews. Main outcome was self-report of possible PASC symptoms 3 weeks or longer after positive COVID-19 test. In-depth interviews were guided by a semi-structured interview guide with open-ended questions and probes based on emerging literature on PASC and the impact of COVID-19. RESULTS: With a survey response rate of 70%, 442 participants were included in this analysis, mean (SD) age 45.4 (16.2) years, 71% female, 12% Black/African American. Compared to those with no PASC symptoms, persons who reported PASC symptoms were more likely to be older (mean age: 46.5 vs. 42; p = 0.013), female (74.3% vs. 61.2%; p = 0.010), to have pre-existing conditions (49.6% vs. 34%; p = 0.005), and to have been hospitalized for COVID-19 (14.2% vs. 2.9%; p = 0.002). About 30% of the participants experienced severe fatigue; the proportion of persons reporting severe fatigue was 7-fold greater in those with PASC symptoms (Adjusted Prevalence Ratio [aPR] 6.73, 95%CI: 2.80-16.18). Persons with PASC symptoms were more likely to report poor quality of life (16% vs. 5%, p<0.001) and worse mental health functioning (Mean difference: -1.87 95%CI: -2.38, -1.37, p<0.001). Themes from in-depth interviews revealed PASC was experienced as debilitating. CONCLUSIONS: In this study, the prevalence of PASC among community-dwelling adults was substantial. Participants reported considerable coping difficulties, restrictions in everyday activities, invisibility of symptoms and experiences, and impediments to getting and receiving PASC care.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation.ispartof	PLoS One
dc.relation.isbasedon	10.1371/journal.pone.0279684
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	General Science & Technology
dc.subject.mesh	Adult
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Middle Aged
dc.subject.mesh	Male
dc.subject.mesh	COVID-19
dc.subject.mesh	Quality of Life
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Disease Progression
dc.subject.mesh	Fatigue
dc.subject.mesh	Self Report
dc.subject.mesh	Humans
dc.subject.mesh	Disease Progression
dc.subject.mesh	Fatigue
dc.subject.mesh	Quality of Life
dc.subject.mesh	Adult
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Self Report
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Adult
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Middle Aged
dc.subject.mesh	Male
dc.subject.mesh	COVID-19
dc.subject.mesh	Quality of Life
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Disease Progression
dc.subject.mesh	Fatigue
dc.subject.mesh	Self Report
dc.title	"Living like an empty gas tank with a leak": Mixed methods study on post-acute sequelae of COVID-19.
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
dc.date.updated	2023-02-10T00:52:33Z
pubs.issue	12
pubs.publication-status	Published online
pubs.volume	17
utslib.citation.issue	12

Abstract:

BACKGROUND: The burden and presentation of post-acute sequela of SARS-CoV-2 infection (PASC) are a developing major public health concern. OBJECTIVES: To characterize the burden of PASC in community-dwelling individuals and understand the experiences of people living with PASC. METHODS: This mixed-methods study of COVID-19 positive community-dwelling persons involved surveys and in-depth interviews. Main outcome was self-report of possible PASC symptoms 3 weeks or longer after positive COVID-19 test. In-depth interviews were guided by a semi-structured interview guide with open-ended questions and probes based on emerging literature on PASC and the impact of COVID-19. RESULTS: With a survey response rate of 70%, 442 participants were included in this analysis, mean (SD) age 45.4 (16.2) years, 71% female, 12% Black/African American. Compared to those with no PASC symptoms, persons who reported PASC symptoms were more likely to be older (mean age: 46.5 vs. 42; p = 0.013), female (74.3% vs. 61.2%; p = 0.010), to have pre-existing conditions (49.6% vs. 34%; p = 0.005), and to have been hospitalized for COVID-19 (14.2% vs. 2.9%; p = 0.002). About 30% of the participants experienced severe fatigue; the proportion of persons reporting severe fatigue was 7-fold greater in those with PASC symptoms (Adjusted Prevalence Ratio [aPR] 6.73, 95%CI: 2.80-16.18). Persons with PASC symptoms were more likely to report poor quality of life (16% vs. 5%, p<0.001) and worse mental health functioning (Mean difference: -1.87 95%CI: -2.38, -1.37, p<0.001). Themes from in-depth interviews revealed PASC was experienced as debilitating. CONCLUSIONS: In this study, the prevalence of PASC among community-dwelling adults was substantial. Participants reported considerable coping difficulties, restrictions in everyday activities, invisibility of symptoms and experiences, and impediments to getting and receiving PASC care.

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http://hdl.handle.net/10453/166026