Multifunctional Virus Manipulation with Large-Scale Arrays of All-Dielectric Resonant Nanocavities

Shi, Y; Wu, Y; Chin, LK; Li, Z; Liu, J; Chen, MK; Wang, S; Zhang, Y; Liu, PY; Zhou, X; Cai, H; Jin, W; Yu, Y; Yu, R; Huang, W; Yap, PH; Xiao, L; Ser, W; Nguyen, TTB; Lin, YT; Wu, PC; Liao, J; Wang, F; Chan, CT; Kivshar, Y; Tsai, DP; Liu, AQ

Multifunctional Virus Manipulation with Large-Scale Arrays of All-Dielectric Resonant Nanocavities

Shi, Y Wu, Y Chin, LK Li, Z Liu, J Chen, MK Wang, S Zhang, Y Liu, PY Zhou, X Cai, H Jin, W Yu, Y Yu, R Huang, W Yap, PH Xiao, L Ser, W Nguyen, TTB Lin, YT Wu, PC Liao, J

Wang, F

Chan, CT Kivshar, Y Tsai, DP Liu, AQ

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Publisher:: WILEY-V C H VERLAG GMBH
Publication Type:: Journal Article
Citation:: Laser and Photonics Reviews, 2022, 16, (5)
Issue Date:: 2022-05-01

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Field	Value	Language
dc.contributor.author	Shi, Y
dc.contributor.author	Wu, Y
dc.contributor.author	Chin, LK
dc.contributor.author	Li, Z
dc.contributor.author	Liu, J
dc.contributor.author	Chen, MK
dc.contributor.author	Wang, S
dc.contributor.author	Zhang, Y
dc.contributor.author	Liu, PY
dc.contributor.author	Zhou, X
dc.contributor.author	Cai, H
dc.contributor.author	Jin, W
dc.contributor.author	Yu, Y
dc.contributor.author	Yu, R
dc.contributor.author	Huang, W
dc.contributor.author	Yap, PH
dc.contributor.author	Xiao, L
dc.contributor.author	Ser, W
dc.contributor.author	Nguyen, TTB
dc.contributor.author	Lin, YT
dc.contributor.author	Wu, PC
dc.contributor.author	Liao, J https://orcid.org/0000-0003-0616-4762
dc.contributor.author	Wang, F https://orcid.org/0000-0001-7403-3305
dc.contributor.author	Chan, CT
dc.contributor.author	Kivshar, Y
dc.contributor.author	Tsai, DP
dc.contributor.author	Liu, AQ
dc.date.accessioned	2023-02-23T03:00:40Z
dc.date.available	2023-02-23T03:00:40Z
dc.date.issued	2022-05-01
dc.identifier.citation	Laser and Photonics Reviews, 2022, 16, (5)
dc.identifier.issn	1863-8880
dc.identifier.issn	1863-8899
dc.identifier.uri	http://hdl.handle.net/10453/166369
dc.description.abstract	Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbitrary number of viruses in an aqueous environment, being restricted by insufficient strength of optical forces and a lack of multifunctional spatial manipulation techniques. Here, by employing the virus hopping and flexibility of moving the laser position, multifunctional virus manipulation with a large trapping area is demonstrated, enabling single or massive (a large quantity of) virus transporting, positioning, patterning, sorting, and concentrating. The enhanced optical forces are produced by the confinement of light in engineered arrays of nanocavities by fine tuning of the interference resonances, and this approach allows trapping and moving viruses down to 40 nm in size. The work paves the way to efficient and precise manipulation of either single or massive groups of viruses, opening a wide range of novel opportunities for virus pathogenesis and inhibitor development at the single-virus level.
dc.language	English
dc.publisher	WILEY-V C H VERLAG GMBH
dc.relation.ispartof	Laser and Photonics Reviews
dc.relation.isbasedon	10.1002/lpor.202100197
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0201 Astronomical and Space Sciences, 0205 Optical Physics, 0206 Quantum Physics
dc.subject.classification	Optoelectronics & Photonics
dc.title	Multifunctional Virus Manipulation with Large-Scale Arrays of All-Dielectric Resonant Nanocavities
dc.type	Journal Article
utslib.citation.volume	16
utslib.for	0201 Astronomical and Space Sciences
utslib.for	0205 Optical Physics
utslib.for	0206 Quantum Physics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - GBDTC - Global Big Data Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-23T03:00:36Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	16
utslib.citation.issue	5

Abstract:

Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbitrary number of viruses in an aqueous environment, being restricted by insufficient strength of optical forces and a lack of multifunctional spatial manipulation techniques. Here, by employing the virus hopping and flexibility of moving the laser position, multifunctional virus manipulation with a large trapping area is demonstrated, enabling single or massive (a large quantity of) virus transporting, positioning, patterning, sorting, and concentrating. The enhanced optical forces are produced by the confinement of light in engineered arrays of nanocavities by fine tuning of the interference resonances, and this approach allows trapping and moving viruses down to 40 nm in size. The work paves the way to efficient and precise manipulation of either single or massive groups of viruses, opening a wide range of novel opportunities for virus pathogenesis and inhibitor development at the single-virus level.

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http://hdl.handle.net/10453/166369