Sodium alginate-based drug delivery for diabetes management: A review.

Shaikh, MAJ; Gupta, G; Goyal, A; Gupta, MM; Afzal, O; Altamimi, ASA; Alzarea, SI; Almalki, WH; Kazmi, I; Negi, P; Singh, SK; Dua, K

Sodium alginate-based drug delivery for diabetes management: A review.

Shaikh, MAJ Gupta, G Goyal, A Gupta, MM Afzal, O Altamimi, ASA Alzarea, SI Almalki, WH Kazmi, I Negi, P Singh, SK Dua, K

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Int J Biol Macromol, 2023, pp. 123986
Issue Date:: 2023-03-09

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Field	Value	Language
dc.contributor.author	Shaikh, MAJ
dc.contributor.author	Gupta, G
dc.contributor.author	Goyal, A
dc.contributor.author	Gupta, MM
dc.contributor.author	Afzal, O
dc.contributor.author	Altamimi, ASA
dc.contributor.author	Alzarea, SI
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Negi, P
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2023-03-16T07:07:52Z
dc.date.available	2023-03-05
dc.date.available	2023-03-16T07:07:52Z
dc.date.issued	2023-03-09
dc.identifier.citation	Int J Biol Macromol, 2023, pp. 123986
dc.identifier.issn	0141-8130
dc.identifier.issn	1879-0003
dc.identifier.uri	http://hdl.handle.net/10453/167377
dc.description.abstract	Diabetes mellitus (DM) is among the biggest global health problems of the 21st century, which is characterised by insufficient insulin secretion and results in the augmentation of blood sugar levels. The current foundation of hyperglycemia therapy is oral antihyperglycemic medications like biguanides, sulphonylureas, α-glucosidase inhibitors, peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose co-transporter 2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and others. Many naturally occurring substances have shown promise in treating hyperglycemia. Inadequate prologitivity of action, restricted bioavailability, site specificity, and dose-related side effects are some problems with currently available anti-diabetic medications. Sodium alginate has shown promise as a drug delivery mechanism, potentially solving issues with current therapies for several substances. This review summarizes the research on the efficacy of drug delivery systems based on alginate for transporting oral hypoglycemic medicines, phytochemicals, and insulin for treating hyperglycemia.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Int J Biol Macromol
dc.relation.isbasedon	10.1016/j.ijbiomac.2023.123986
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Polymers
dc.title	Sodium alginate-based drug delivery for diabetes management: A review.
dc.type	Journal Article
utslib.location.activity	Netherlands
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2023-03-16T07:07:47Z
pubs.publication-status	Published online

Abstract:

Diabetes mellitus (DM) is among the biggest global health problems of the 21st century, which is characterised by insufficient insulin secretion and results in the augmentation of blood sugar levels. The current foundation of hyperglycemia therapy is oral antihyperglycemic medications like biguanides, sulphonylureas, α-glucosidase inhibitors, peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose co-transporter 2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and others. Many naturally occurring substances have shown promise in treating hyperglycemia. Inadequate prologitivity of action, restricted bioavailability, site specificity, and dose-related side effects are some problems with currently available anti-diabetic medications. Sodium alginate has shown promise as a drug delivery mechanism, potentially solving issues with current therapies for several substances. This review summarizes the research on the efficacy of drug delivery systems based on alginate for transporting oral hypoglycemic medicines, phytochemicals, and insulin for treating hyperglycemia.

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http://hdl.handle.net/10453/167377