Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms.

Shi, X; Xia, Y; Wei, W; Ni, B-J

Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms.

Shi, X

Xia, Y Wei, W Ni, B-J

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Publisher:: PERGAMON-ELSEVIER SCIENCE LTD
Publication Type:: Journal Article
Citation:: Water Res, 2022, 224, pp. 119060
Issue Date:: 2022-10-01

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Field	Value	Language
dc.contributor.author	Shi, X https://orcid.org/0000-0001-8403-3392
dc.contributor.author	Xia, Y
dc.contributor.author	Wei, W
dc.contributor.author	Ni, B-J
dc.date.accessioned	2023-03-19T23:55:36Z
dc.date.available	2022-09-04
dc.date.available	2023-03-19T23:55:36Z
dc.date.issued	2022-10-01
dc.identifier.citation	Water Res, 2022, 224, pp. 119060
dc.identifier.issn	0043-1354
dc.identifier.issn	1879-2448
dc.identifier.uri	http://hdl.handle.net/10453/167636
dc.description.abstract	The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been conventionally attributed to the abuse and misuse of antibiotics. However, the ancient ARGs have alterative functions in bacterial physiology and thus they could be co-regulated by non-antibiotic conditions. Recent research has demonstrated that many non-antibiotic chemicals such as microplastics, metallic nanoparticles and non-antibiotic drugs, as well as some non-antibiotic conditions, can accelerate the dissemination of ARGs. These results suggested that the role of antibiotics might have been previously overestimated whereas the effects of non-antibiotic conditions were possibly ignored. Thus, in an attempt to fully understand the fate and behavior of ARGs in the eco-system, it is urgent to critically highlight the role and mechanisms of non-antibiotic chemicals and related environmental factors in the spread of ARGs. To this end, this timely review assessed the evolution of ARGs, especially its function alteration, summarized the non-antibiotic chemicals promoting the spread of ARGs, evaluated the non-antibiotic conditions related to ARG dissemination and analyzed the molecular mechanisms related to spread of ARGs induced by the non-antibiotic factors. Finally, this review then provided several critical perspectives for future research.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD
dc.relation	http://purl.org/au-research/grants/arc/DP220101139
dc.relation	http://purl.org/au-research/grants/arc/DE220100530
dc.relation.ispartof	Water Res
dc.relation.isbasedon	10.1016/j.watres.2022.119060
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Environmental Engineering
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Microbial
dc.subject.mesh	Genes, Bacterial
dc.subject.mesh	Microplastics
dc.subject.mesh	Plastics
dc.subject.mesh	Plastics
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Microbial
dc.subject.mesh	Genes, Bacterial
dc.subject.mesh	Microplastics
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Microbial
dc.subject.mesh	Genes, Bacterial
dc.subject.mesh	Microplastics
dc.subject.mesh	Plastics
dc.title	Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms.
dc.type	Journal Article
utslib.citation.volume	224
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access	*
dc.date.updated	2023-03-19T23:55:34Z
pubs.publication-status	Published
pubs.volume	224

Abstract:

The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been conventionally attributed to the abuse and misuse of antibiotics. However, the ancient ARGs have alterative functions in bacterial physiology and thus they could be co-regulated by non-antibiotic conditions. Recent research has demonstrated that many non-antibiotic chemicals such as microplastics, metallic nanoparticles and non-antibiotic drugs, as well as some non-antibiotic conditions, can accelerate the dissemination of ARGs. These results suggested that the role of antibiotics might have been previously overestimated whereas the effects of non-antibiotic conditions were possibly ignored. Thus, in an attempt to fully understand the fate and behavior of ARGs in the eco-system, it is urgent to critically highlight the role and mechanisms of non-antibiotic chemicals and related environmental factors in the spread of ARGs. To this end, this timely review assessed the evolution of ARGs, especially its function alteration, summarized the non-antibiotic chemicals promoting the spread of ARGs, evaluated the non-antibiotic conditions related to ARG dissemination and analyzed the molecular mechanisms related to spread of ARGs induced by the non-antibiotic factors. Finally, this review then provided several critical perspectives for future research.

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http://hdl.handle.net/10453/167636