Gold/silver decorated magnetic nanostructures as theranostic agents: Synthesis, characterization and in-vitro study

Abbasi Kajani, A; Bordbar, AK; Zarkesh-Esfahani, SH; Razmjou, A; Hou, J

Gold/silver decorated magnetic nanostructures as theranostic agents: Synthesis, characterization and in-vitro study

Abbasi Kajani, A Bordbar, AK Zarkesh-Esfahani, SH Razmjou, A Hou, J

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Publisher:: ELSEVIER SCIENCE BV
Publication Type:: Journal Article
Citation:: Journal of Molecular Liquids, 2017, 247, pp. 238-245
Issue Date:: 2017-12-01

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Field	Value	Language
dc.contributor.author	Abbasi Kajani, A
dc.contributor.author	Bordbar, AK
dc.contributor.author	Zarkesh-Esfahani, SH
dc.contributor.author	Razmjou, A
dc.contributor.author	Hou, J
dc.date.accessioned	2023-03-26T23:37:40Z
dc.date.available	2023-03-26T23:37:40Z
dc.date.issued	2017-12-01
dc.identifier.citation	Journal of Molecular Liquids, 2017, 247, pp. 238-245
dc.identifier.issn	0167-7322
dc.identifier.issn	1873-3166
dc.identifier.uri	http://hdl.handle.net/10453/168482
dc.description.abstract	A facile and novel semi-biosynthesis method was reported to develop multifunctional magnetic-plasmonic nanostructures with potent and specific anticancer activity. Silver and gold nanoseeds were synthesized in the presence of Taxus baccata extracted Taxanes, as reducing and capping agents, and used to decorate the silica coated iron oxide nanoparticles. The resulted nanostructures were characterized using UV–Vis spectroscopy, FE-SEM, TEM, FTIR, EDS, and DLS. The resulted hollow and porous nanostructures displayed semi-spherical shapes and sizes between 200 and 500 nm with appropriate magnetic and plasmonic properties. FTIR analysis showed efficient encapsulation of nanostructures by the organic compounds which led to their appropriate colloidal stability. MTT assay and microscopic studies revealed potent and specific anticancer activity of silver decorated magnetic nanostructures (FeAg-Ns), so that after 48 h incubation of human cervical (HeLa) and breast (MCF-7) cancer cells with 100 μg mL− 1 FeAg-Ns up to 70.4 ± 2.02 and 98.6 ± 2.36% mortality were obtained, respectively. Moreover, the nanostructures displayed significantly less cytotoxicity (up to 40.5 ± 1.82%) on noncancerous human fibroblast cells. In conclusion, the synthesized nanostructures have great potential to develop theranostic agents for bio-imaging and magnetically targeted cancer therapy.
dc.language	English
dc.publisher	ELSEVIER SCIENCE BV
dc.relation.ispartof	Journal of Molecular Liquids
dc.relation.isbasedon	10.1016/j.molliq.2017.09.119
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0306 Physical Chemistry (incl. Structural)
dc.subject.classification	Chemical Physics
dc.title	Gold/silver decorated magnetic nanostructures as theranostic agents: Synthesis, characterization and in-vitro study
dc.type	Journal Article
utslib.citation.volume	247
utslib.for	0306 Physical Chemistry (incl. Structural)
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2023-03-26T23:37:39Z
pubs.publication-status	Published
pubs.volume	247

Abstract:

A facile and novel semi-biosynthesis method was reported to develop multifunctional magnetic-plasmonic nanostructures with potent and specific anticancer activity. Silver and gold nanoseeds were synthesized in the presence of Taxus baccata extracted Taxanes, as reducing and capping agents, and used to decorate the silica coated iron oxide nanoparticles. The resulted nanostructures were characterized using UV–Vis spectroscopy, FE-SEM, TEM, FTIR, EDS, and DLS. The resulted hollow and porous nanostructures displayed semi-spherical shapes and sizes between 200 and 500 nm with appropriate magnetic and plasmonic properties. FTIR analysis showed efficient encapsulation of nanostructures by the organic compounds which led to their appropriate colloidal stability. MTT assay and microscopic studies revealed potent and specific anticancer activity of silver decorated magnetic nanostructures (FeAg-Ns), so that after 48 h incubation of human cervical (HeLa) and breast (MCF-7) cancer cells with 100 μg mL− 1 FeAg-Ns up to 70.4 ± 2.02 and 98.6 ± 2.36% mortality were obtained, respectively. Moreover, the nanostructures displayed significantly less cytotoxicity (up to 40.5 ± 1.82%) on noncancerous human fibroblast cells. In conclusion, the synthesized nanostructures have great potential to develop theranostic agents for bio-imaging and magnetically targeted cancer therapy.

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http://hdl.handle.net/10453/168482