Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Prasher, P; Sharma, M; Singh, SK; Gulati, M; Chellappan, DK; Rajput, R; Gupta, G; Ydyrys, A; Kulbayeva, M; Abdull Razis, AF; Modu, B; Sharifi-Rad, J; Dua, K

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Prasher, P Sharma, M Singh, SK Gulati, M Chellappan, DK Rajput, R Gupta, G Ydyrys, A Kulbayeva, M Abdull Razis, AF Modu, B Sharifi-Rad, J Dua, K

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in Chemistry, 11

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Field	Value	Language
dc.contributor.author	Prasher, P
dc.contributor.author	Sharma, M
dc.contributor.author	Singh, SK
dc.contributor.author	Gulati, M
dc.contributor.author	Chellappan, DK
dc.contributor.author	Rajput, R
dc.contributor.author	Gupta, G
dc.contributor.author	Ydyrys, A
dc.contributor.author	Kulbayeva, M
dc.contributor.author	Abdull Razis, AF
dc.contributor.author	Modu, B
dc.contributor.author	Sharifi-Rad, J
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2023-04-08T16:12:49Z
dc.date.available	2023-04-08T16:12:49Z
dc.identifier.citation	Frontiers in Chemistry, 11
dc.identifier.issn	2296-2646
dc.identifier.uri	http://hdl.handle.net/10453/169390
dc.description.abstract	<jats:p>Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibition of tumor cell proliferation and suppression of tumor growth. Moreover, it also triggers autophagy by regulating key oncologic pathways. The increased intake of polyamines, such as spermidine, can suppress oncogenesis and slow the growth of tumors due to its role in anticancer immunosurveillance and regulation of polyamine metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays a critical role in polyamine homeostasis and serves as a diagnostic marker in human cancers. Chemically modified derivatives of spermidine hold great potential for prognostic, diagnostic, and therapeutic applications against various malignancies. This review discusses in detail the recent findings that support the anticancer mechanisms of spermidine and its molecular physiology.</jats:p>
dc.language	en
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Frontiers in Chemistry
dc.relation.isbasedon	10.3389/fchem.2023.1164477
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights	© 2023 Prasher, Sharma, Singh, Gulati, Chellappan, Rajput, Gupta, Ydyrys, Kulbayeva, Abdull Razis, Modu, Sharifi-Rad and Dua. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.title	Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
dc.type	Journal Article
utslib.citation.volume	11
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	recently_added	*
dc.date.updated	2023-04-08T16:12:47Z
pubs.publication-status	Published online
pubs.volume	11

Abstract:

Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibition of tumor cell proliferation and suppression of tumor growth. Moreover, it also triggers autophagy by regulating key oncologic pathways. The increased intake of polyamines, such as spermidine, can suppress oncogenesis and slow the growth of tumors due to its role in anticancer immunosurveillance and regulation of polyamine metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays a critical role in polyamine homeostasis and serves as a diagnostic marker in human cancers. Chemically modified derivatives of spermidine hold great potential for prognostic, diagnostic, and therapeutic applications against various malignancies. This review discusses in detail the recent findings that support the anticancer mechanisms of spermidine and its molecular physiology.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/169390