SARS-CoV-2 shedding sources in wastewater and implications for wastewater-based epidemiology.

Li, X; Kulandaivelu, J; Guo, Y; Zhang, S; Shi, J; O'Brien, J; Arora, S; Kumar, M; Sherchan, SP; Honda, R; Jackson, G; Luby, SP; Jiang, G

SARS-CoV-2 shedding sources in wastewater and implications for wastewater-based epidemiology.

Li, X

Kulandaivelu, J Guo, Y Zhang, S Shi, J O'Brien, J Arora, S Kumar, M Sherchan, SP Honda, R Jackson, G Luby, SP Jiang, G

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: J Hazard Mater, 2022, 432, pp. 128667
Issue Date:: 2022-06-15

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Field	Value	Language
dc.contributor.author	Li, X https://orcid.org/0000-0003-1768-9556
dc.contributor.author	Kulandaivelu, J
dc.contributor.author	Guo, Y
dc.contributor.author	Zhang, S
dc.contributor.author	Shi, J
dc.contributor.author	O'Brien, J
dc.contributor.author	Arora, S
dc.contributor.author	Kumar, M
dc.contributor.author	Sherchan, SP
dc.contributor.author	Honda, R
dc.contributor.author	Jackson, G
dc.contributor.author	Luby, SP
dc.contributor.author	Jiang, G
dc.date.accessioned	2023-04-11T03:06:10Z
dc.date.available	2022-03-08
dc.date.available	2023-04-11T03:06:10Z
dc.date.issued	2022-06-15
dc.identifier.citation	J Hazard Mater, 2022, 432, pp. 128667
dc.identifier.issn	0304-3894
dc.identifier.issn	1873-3336
dc.identifier.uri	http://hdl.handle.net/10453/169524
dc.description.abstract	Wastewater-based epidemiology (WBE) approach for COVID-19 surveillance is largely based on the assumption of SARS-CoV-2 RNA shedding into sewers by infected individuals. Recent studies found that SARS-CoV-2 RNA concentration in wastewater (CRNA) could not be accounted by the fecal shedding alone. This study aimed to determine potential major shedding sources based on literature data of CRNA, along with the COVID-19 prevalence in the catchment area through a systematic literature review. Theoretical CRNA under a certain prevalence was estimated using Monte Carlo simulations, with eight scenarios accommodating feces alone, and both feces and sputum as shedding sources. With feces alone, none of the WBE data was in the confidence interval of theoretical CRNA estimated with the mean feces shedding magnitude and probability, and 63% of CRNA in WBE reports were higher than the maximum theoretical concentration. With both sputum and feces, 91% of the WBE data were below the simulated maximum CRNA in wastewater. The inclusion of sputum as a major shedding source led to more comparable theoretical CRNA to the literature WBE data. Sputum discharging behavior of patients also resulted in great fluctuations of CRNA under a certain prevalence. Thus, sputum is a potential critical shedding source for COVID-19 WBE surveillance.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	J Hazard Mater
dc.relation.isbasedon	10.1016/j.jhazmat.2022.128667
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences, 05 Environmental Sciences, 09 Engineering
dc.subject.classification	Strategic, Defence & Security Studies
dc.subject.mesh	COVID-19
dc.subject.mesh	Humans
dc.subject.mesh	RNA, Viral
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Wastewater
dc.subject.mesh	Wastewater-Based Epidemiological Monitoring
dc.subject.mesh	Humans
dc.subject.mesh	RNA, Viral
dc.subject.mesh	Wastewater-Based Epidemiological Monitoring
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Wastewater
dc.subject.mesh	COVID-19
dc.subject.mesh	Humans
dc.subject.mesh	RNA, Viral
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Wastewater
dc.subject.mesh	Wastewater-Based Epidemiological Monitoring
dc.title	SARS-CoV-2 shedding sources in wastewater and implications for wastewater-based epidemiology.
dc.type	Journal Article
utslib.citation.volume	432
utslib.location.activity	Netherlands
utslib.for	03 Chemical Sciences
utslib.for	05 Environmental Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access	*
dc.date.updated	2023-04-11T03:06:06Z
pubs.publication-status	Published
pubs.volume	432

Abstract:

Wastewater-based epidemiology (WBE) approach for COVID-19 surveillance is largely based on the assumption of SARS-CoV-2 RNA shedding into sewers by infected individuals. Recent studies found that SARS-CoV-2 RNA concentration in wastewater (CRNA) could not be accounted by the fecal shedding alone. This study aimed to determine potential major shedding sources based on literature data of CRNA, along with the COVID-19 prevalence in the catchment area through a systematic literature review. Theoretical CRNA under a certain prevalence was estimated using Monte Carlo simulations, with eight scenarios accommodating feces alone, and both feces and sputum as shedding sources. With feces alone, none of the WBE data was in the confidence interval of theoretical CRNA estimated with the mean feces shedding magnitude and probability, and 63% of CRNA in WBE reports were higher than the maximum theoretical concentration. With both sputum and feces, 91% of the WBE data were below the simulated maximum CRNA in wastewater. The inclusion of sputum as a major shedding source led to more comparable theoretical CRNA to the literature WBE data. Sputum discharging behavior of patients also resulted in great fluctuations of CRNA under a certain prevalence. Thus, sputum is a potential critical shedding source for COVID-19 WBE surveillance.

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http://hdl.handle.net/10453/169524