Lanthanide ions in nanocrystals for biophotonics application

Chen, C; Liu, B; Liao, J; Ding, L; Shan, X; Wang, F

Lanthanide ions in nanocrystals for biophotonics application

Chen, C

Liu, B

Liao, J

Ding, L

Shan, X Wang, F

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Publisher:: SPIE, the international society for optics and photonics
Publication Type:: Conference Proceeding
Citation:: Proceedings of SPIE - The International Society for Optical Engineering, 2022, 12277, pp. 122770f-122770f-6
Issue Date:: 2022-07-23

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Field	Value	Language
dc.contributor.author	Chen, C https://orcid.org/0000-0003-4620-7771
dc.contributor.author	Liu, B https://orcid.org/0000-0002-4779-4683
dc.contributor.author	Liao, J https://orcid.org/0000-0003-0616-4762
dc.contributor.author	Ding, L https://orcid.org/0000-0002-9574-5165
dc.contributor.author	Shan, X
dc.contributor.author	Wang, F https://orcid.org/0000-0001-7403-3305
dc.contributor.editor	Liu, J
dc.contributor.editor	Jia, B
dc.contributor.editor	Yao, X
dc.contributor.editor	Wang, Y
dc.contributor.editor	Cao, L
dc.contributor.editor	Nomura, T
dc.date	2022-04-08
dc.date.accessioned	2023-04-14T03:46:42Z
dc.date.available	2023-04-14T03:46:42Z
dc.date.issued	2022-07-23
dc.identifier.citation	Proceedings of SPIE - The International Society for Optical Engineering, 2022, 12277, pp. 122770f-122770f-6
dc.identifier.isbn	9781510655591
dc.identifier.issn	0277-786X
dc.identifier.issn	1996-756X
dc.identifier.uri	http://hdl.handle.net/10453/169795
dc.description.abstract	Upconversion nanoparticles (UCNPs) is a series of lanthanoid ions doped nanocrystals that are of great interest for biomedical applications, including nanoscale optical sensing and imaging, benefiting from its bright, stable, multicolour emission. Each of the nanoparticles contains thousands of Lanthanide ions, which works as both sensitizers and activators to absorb the near-infrared photons and transfer the energy from sensitizers to activators through nonlinear energy transferring process for an upconverting emission. A few new super-resolution imaging methods have been developed recently based on UCNPs’ unique nonlinear energy transferring process. Most recently, upon these advances, we have found that the thousands of Lanthanide ions provide a strong dielectric resonance effect in a single UCNP. In this work, we will review using the nonlinear response of lanthanoid ions to improve super-resolution nanoscopy. We will also report the ion resonance effect in UCNPs could substantially increase the permittivity and polarizability of nanocrystals, leading to an enhanced optical force on a single 23.3 nm radius UCNP, more than 30 times stronger than the reported value for gold nanoparticles with the same size. The enhanced optical force also provides a way to bypass the optical trapping requirement of “refractive index mismatch”. We further report that the resonance effect could engineer the Rayleigh scattering of UCNPs. These applications suggest a new potential of UCNPs as force probe, scattering probe and fluorescence probe simultaneously for multiplexed imaging.
dc.language	en
dc.publisher	SPIE, the international society for optics and photonics
dc.relation.ispartof	Proceedings of SPIE - The International Society for Optical Engineering
dc.relation.ispartof	2021 International Conference on Optical Instruments and Technology: Optical Systems, Optoelectronic Instruments, Novel Display, and Imaging Technology
dc.relation.isbasedon	10.1117/12.2618300
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Lanthanide ions in nanocrystals for biophotonics application
dc.type	Conference Proceeding
utslib.citation.volume	12277
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - GBDTC - Global Big Data Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-04-14T03:46:41Z
pubs.finish-date	2022-04-10
pubs.publication-status	Published
pubs.start-date	2022-04-08
pubs.volume	12277

Abstract:

Upconversion nanoparticles (UCNPs) is a series of lanthanoid ions doped nanocrystals that are of great interest for biomedical applications, including nanoscale optical sensing and imaging, benefiting from its bright, stable, multicolour emission. Each of the nanoparticles contains thousands of Lanthanide ions, which works as both sensitizers and activators to absorb the near-infrared photons and transfer the energy from sensitizers to activators through nonlinear energy transferring process for an upconverting emission. A few new super-resolution imaging methods have been developed recently based on UCNPs’ unique nonlinear energy transferring process. Most recently, upon these advances, we have found that the thousands of Lanthanide ions provide a strong dielectric resonance effect in a single UCNP. In this work, we will review using the nonlinear response of lanthanoid ions to improve super-resolution nanoscopy. We will also report the ion resonance effect in UCNPs could substantially increase the permittivity and polarizability of nanocrystals, leading to an enhanced optical force on a single 23.3 nm radius UCNP, more than 30 times stronger than the reported value for gold nanoparticles with the same size. The enhanced optical force also provides a way to bypass the optical trapping requirement of “refractive index mismatch”. We further report that the resonance effect could engineer the Rayleigh scattering of UCNPs. These applications suggest a new potential of UCNPs as force probe, scattering probe and fluorescence probe simultaneously for multiplexed imaging.

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http://hdl.handle.net/10453/169795