Relationship Between Thyroid Hormone and Liver Steatosis Analysis Parameter in Obese Participants: A Case-Control Study.

Chen, S; Jin, Y; Xu, M; Zhang, P; Zhou, Y; Qian, X; Song, Q; Bu, S; Sun, J; Li, L

Relationship Between Thyroid Hormone and Liver Steatosis Analysis Parameter in Obese Participants: A Case-Control Study.

Chen, S Jin, Y Xu, M Zhang, P Zhou, Y Qian, X Song, Q Bu, S Sun, J

Li, L

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Publisher:: Taylor & Francis
Publication Type:: Journal Article
Citation:: Diabetes Metab Syndr Obes, 2022, 15, pp. 887-896
Issue Date:: 2022

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Field	Value	Language
dc.contributor.author	Chen, S
dc.contributor.author	Jin, Y
dc.contributor.author	Xu, M
dc.contributor.author	Zhang, P
dc.contributor.author	Zhou, Y
dc.contributor.author	Qian, X
dc.contributor.author	Song, Q
dc.contributor.author	Bu, S
dc.contributor.author	Sun, J https://orcid.org/0000-0002-0097-2438
dc.contributor.author	Li, L
dc.date.accessioned	2023-04-18T02:06:17Z
dc.date.available	2022-03-10
dc.date.available	2023-04-18T02:06:17Z
dc.date.issued	2022
dc.identifier.citation	Diabetes Metab Syndr Obes, 2022, 15, pp. 887-896
dc.identifier.issn	1178-7007
dc.identifier.issn	1178-7007
dc.identifier.uri	http://hdl.handle.net/10453/169895
dc.description.abstract	OBJECTIVE: The thyroid hormone has been demonstrated to be associated with nonalcoholic fatty liver disease (NAFLD) in different populations. However, the relationship between thyroid hormone and the degree of liver steatosis in overweight/obese subjects is still unclear. Liver ultra-sound attenuation (LiSA) is a newly developed ultrasound attenuation parameter for the analysis of hepatic steatosis. The study aimed to characterize the relationship between thyroid hormone and LiSA in overweight/obese participants. METHODS: This case-control study was performed in Ningbo First Hospital, China. A total of 24 lean, 66 overweight and 49 obese participants were consecutively recruited from January 2021 to May 2021. Thyroid hormone and other clinical features were measured. LiSA was acquired by using a Hepatus ultrasound machine. Multiple linear regression analyses were performed to examine associations of LiSA and clinic indices. RESULTS: Obese subjects had higher LiSA, fT3 and TSH levels than lean participants of similar age and sex (P < 0.05). LiSA was positively associated with the fT3 level. The multiple linear regression analyses showed that fT3 (ß = 0.353, P < 0.001) was independently associated with LiSA in overweight/obese participants. CONCLUSION: The fT3 level was independently associated with the degree of liver steatosis among the overweight/obese participants.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Taylor & Francis
dc.relation.ispartof	Diabetes Metab Syndr Obes
dc.relation.isbasedon	10.2147/DMSO.S356882
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1101 Medical Biochemistry and Metabolomics
dc.title	Relationship Between Thyroid Hormone and Liver Steatosis Analysis Parameter in Obese Participants: A Case-Control Study.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	New Zealand
utslib.for	1101 Medical Biochemistry and Metabolomics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
utslib.copyright.status	open_access	*
dc.date.updated	2023-04-18T02:06:12Z
pubs.publication-status	Published online
pubs.volume	15

Abstract:

OBJECTIVE: The thyroid hormone has been demonstrated to be associated with nonalcoholic fatty liver disease (NAFLD) in different populations. However, the relationship between thyroid hormone and the degree of liver steatosis in overweight/obese subjects is still unclear. Liver ultra-sound attenuation (LiSA) is a newly developed ultrasound attenuation parameter for the analysis of hepatic steatosis. The study aimed to characterize the relationship between thyroid hormone and LiSA in overweight/obese participants. METHODS: This case-control study was performed in Ningbo First Hospital, China. A total of 24 lean, 66 overweight and 49 obese participants were consecutively recruited from January 2021 to May 2021. Thyroid hormone and other clinical features were measured. LiSA was acquired by using a Hepatus ultrasound machine. Multiple linear regression analyses were performed to examine associations of LiSA and clinic indices. RESULTS: Obese subjects had higher LiSA, fT3 and TSH levels than lean participants of similar age and sex (P < 0.05). LiSA was positively associated with the fT3 level. The multiple linear regression analyses showed that fT3 (ß = 0.353, P < 0.001) was independently associated with LiSA in overweight/obese participants. CONCLUSION: The fT3 level was independently associated with the degree of liver steatosis among the overweight/obese participants.

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