Admixture has obscured signals of historical hard sweeps in humans.
Souilmi, Y
Tobler, R
Johar, A
Williams, M
Grey, ST
Schmidt, J
Teixeira, JC
Rohrlach, A
Tuke, J
Johnson, O
Gower, G
Turney, C
Cox, M
Cooper, A
Huber, CD
- Publisher:
- Springer Nature
- Publication Type:
- Journal Article
- Citation:
- Nat Ecol Evol, 2022, 6, (12), pp. 2003-2015
- Issue Date:
- 2022-12
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Souilmi, Y | |
dc.contributor.author | Tobler, R | |
dc.contributor.author | Johar, A | |
dc.contributor.author | Williams, M | |
dc.contributor.author | Grey, ST | |
dc.contributor.author | Schmidt, J | |
dc.contributor.author | Teixeira, JC | |
dc.contributor.author | Rohrlach, A | |
dc.contributor.author | Tuke, J | |
dc.contributor.author | Johnson, O | |
dc.contributor.author | Gower, G | |
dc.contributor.author |
Turney, C https://orcid.org/0000-0001-6733-0993 |
|
dc.contributor.author | Cox, M | |
dc.contributor.author | Cooper, A | |
dc.contributor.author | Huber, CD | |
dc.date.accessioned | 2023-06-24T10:24:38Z | |
dc.date.available | 2022-09-16 | |
dc.date.available | 2023-06-24T10:24:38Z | |
dc.date.issued | 2022-12 | |
dc.identifier.citation | Nat Ecol Evol, 2022, 6, (12), pp. 2003-2015 | |
dc.identifier.issn | 2397-334X | |
dc.identifier.issn | 2397-334X | |
dc.identifier.uri | http://hdl.handle.net/10453/170858 | |
dc.description.abstract | The role of natural selection in shaping biological diversity is an area of intense interest in modern biology. To date, studies of positive selection have primarily relied on genomic datasets from contemporary populations, which are susceptible to confounding factors associated with complex and often unknown aspects of population history. In particular, admixture between diverged populations can distort or hide prior selection events in modern genomes, though this process is not explicitly accounted for in most selection studies despite its apparent ubiquity in humans and other species. Through analyses of ancient and modern human genomes, we show that previously reported Holocene-era admixture has masked more than 50 historic hard sweeps in modern European genomes. Our results imply that this canonical mode of selection has probably been underappreciated in the evolutionary history of humans and suggest that our current understanding of the tempo and mode of selection in natural populations may be inaccurate. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Springer Nature | |
dc.relation.ispartof | Nat Ecol Evol | |
dc.relation.isbasedon | 10.1038/s41559-022-01914-9 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Selection, Genetic | |
dc.subject.mesh | Hominidae | |
dc.subject.mesh | Biological Evolution | |
dc.subject.mesh | Genome, Human | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Hominidae | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Genome, Human | |
dc.subject.mesh | Selection, Genetic | |
dc.subject.mesh | Biological Evolution | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Selection, Genetic | |
dc.subject.mesh | Hominidae | |
dc.subject.mesh | Biological Evolution | |
dc.subject.mesh | Genome, Human | |
dc.subject.mesh | Genomics | |
dc.title | Admixture has obscured signals of historical hard sweeps in humans. | |
dc.type | Journal Article | |
utslib.citation.volume | 6 | |
utslib.location.activity | England | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/DVC (Research) | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-06-24T10:24:32Z | |
pubs.issue | 12 | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
utslib.citation.issue | 12 |
Abstract:
The role of natural selection in shaping biological diversity is an area of intense interest in modern biology. To date, studies of positive selection have primarily relied on genomic datasets from contemporary populations, which are susceptible to confounding factors associated with complex and often unknown aspects of population history. In particular, admixture between diverged populations can distort or hide prior selection events in modern genomes, though this process is not explicitly accounted for in most selection studies despite its apparent ubiquity in humans and other species. Through analyses of ancient and modern human genomes, we show that previously reported Holocene-era admixture has masked more than 50 historic hard sweeps in modern European genomes. Our results imply that this canonical mode of selection has probably been underappreciated in the evolutionary history of humans and suggest that our current understanding of the tempo and mode of selection in natural populations may be inaccurate.
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