Admixture has obscured signals of historical hard sweeps in humans.

Souilmi, Y; Tobler, R; Johar, A; Williams, M; Grey, ST; Schmidt, J; Teixeira, JC; Rohrlach, A; Tuke, J; Johnson, O; Gower, G; Turney, C; Cox, M; Cooper, A; Huber, CD

Admixture has obscured signals of historical hard sweeps in humans.

Souilmi, Y Tobler, R Johar, A Williams, M Grey, ST Schmidt, J Teixeira, JC Rohrlach, A Tuke, J Johnson, O Gower, G Turney, C

Cox, M Cooper, A Huber, CD

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Nat Ecol Evol, 2022, 6, (12), pp. 2003-2015
Issue Date:: 2022-12

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Field	Value	Language
dc.contributor.author	Souilmi, Y
dc.contributor.author	Tobler, R
dc.contributor.author	Johar, A
dc.contributor.author	Williams, M
dc.contributor.author	Grey, ST
dc.contributor.author	Schmidt, J
dc.contributor.author	Teixeira, JC
dc.contributor.author	Rohrlach, A
dc.contributor.author	Tuke, J
dc.contributor.author	Johnson, O
dc.contributor.author	Gower, G
dc.contributor.author	Turney, C https://orcid.org/0000-0001-6733-0993
dc.contributor.author	Cox, M
dc.contributor.author	Cooper, A
dc.contributor.author	Huber, CD
dc.date.accessioned	2023-06-24T10:24:38Z
dc.date.available	2022-09-16
dc.date.available	2023-06-24T10:24:38Z
dc.date.issued	2022-12
dc.identifier.citation	Nat Ecol Evol, 2022, 6, (12), pp. 2003-2015
dc.identifier.issn	2397-334X
dc.identifier.issn	2397-334X
dc.identifier.uri	http://hdl.handle.net/10453/170858
dc.description.abstract	The role of natural selection in shaping biological diversity is an area of intense interest in modern biology. To date, studies of positive selection have primarily relied on genomic datasets from contemporary populations, which are susceptible to confounding factors associated with complex and often unknown aspects of population history. In particular, admixture between diverged populations can distort or hide prior selection events in modern genomes, though this process is not explicitly accounted for in most selection studies despite its apparent ubiquity in humans and other species. Through analyses of ancient and modern human genomes, we show that previously reported Holocene-era admixture has masked more than 50 historic hard sweeps in modern European genomes. Our results imply that this canonical mode of selection has probably been underappreciated in the evolutionary history of humans and suggest that our current understanding of the tempo and mode of selection in natural populations may be inaccurate.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Nat Ecol Evol
dc.relation.isbasedon	10.1038/s41559-022-01914-9
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Selection, Genetic
dc.subject.mesh	Hominidae
dc.subject.mesh	Biological Evolution
dc.subject.mesh	Genome, Human
dc.subject.mesh	Genomics
dc.subject.mesh	Animals
dc.subject.mesh	Hominidae
dc.subject.mesh	Humans
dc.subject.mesh	Genomics
dc.subject.mesh	Genome, Human
dc.subject.mesh	Selection, Genetic
dc.subject.mesh	Biological Evolution
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Selection, Genetic
dc.subject.mesh	Hominidae
dc.subject.mesh	Biological Evolution
dc.subject.mesh	Genome, Human
dc.subject.mesh	Genomics
dc.title	Admixture has obscured signals of historical hard sweeps in humans.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/DVC (Research)
utslib.copyright.status	open_access	*
dc.date.updated	2023-06-24T10:24:32Z
pubs.issue	12
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	12

Abstract:

The role of natural selection in shaping biological diversity is an area of intense interest in modern biology. To date, studies of positive selection have primarily relied on genomic datasets from contemporary populations, which are susceptible to confounding factors associated with complex and often unknown aspects of population history. In particular, admixture between diverged populations can distort or hide prior selection events in modern genomes, though this process is not explicitly accounted for in most selection studies despite its apparent ubiquity in humans and other species. Through analyses of ancient and modern human genomes, we show that previously reported Holocene-era admixture has masked more than 50 historic hard sweeps in modern European genomes. Our results imply that this canonical mode of selection has probably been underappreciated in the evolutionary history of humans and suggest that our current understanding of the tempo and mode of selection in natural populations may be inaccurate.

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http://hdl.handle.net/10453/170858