The effect of regular, low-dose, sustained-release morphine on routine physical activity in people with persistent breathlessness- a hypothesis-generating study.
- Publisher:
- ERS Publications
- Publication Type:
- Journal Article
- Citation:
- European Respiratory Journal, 2022, 60, (6), pp. 1-4
- Issue Date:
- 2022-11-10
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| Filename | Description | Size | |||
|---|---|---|---|---|---|
| 20941255_10975744640005671.pdf | Published version | 297.68 kB |
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Chronic breathlessness, which may be better described as persistent breathlessness to optimise applicability to different languages, is a frequent cause of disability in COPD [1]. In many people with advanced COPD, optimising treatment for the underlying causes of breathlessness and employing non-pharmacological approaches does not achieve symptom control [2]. Some people with persistent breathlessness may benefit from regular, low-dose, sustained-release (SR) morphine [3]. Importantly, changes in unidimensional breathlessness measures do not always reflect the patient's perspective of benefit [4]. Optimal ways of measuring meaningful changes in persistent breathlessness are debated [5], but small functional gains are valued by patients [6]. These gains may be reflected in periods of more intense energy expenditure, allowing people to better maintain independence.
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