From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

Hussain, MS; Gupta, G; Goyal, A; Thapa, R; almalki, WH; Kazmi, I; Alzarea, SI; Fuloria, S; Meenakshi, DU; Jakhmola, V; Pandey, M; Singh, SK; Dua, K

From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

Hussain, MS Gupta, G Goyal, A Thapa, R almalki, WH Kazmi, I Alzarea, SI Fuloria, S Meenakshi, DU Jakhmola, V Pandey, M Singh, SK Dua, K

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Journal of Biochemical and Molecular Toxicology

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Field	Value	Language
dc.contributor.author	Hussain, MS
dc.contributor.author	Gupta, G
dc.contributor.author	Goyal, A
dc.contributor.author	Thapa, R
dc.contributor.author	almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Fuloria, S
dc.contributor.author	Meenakshi, DU
dc.contributor.author	Jakhmola, V
dc.contributor.author	Pandey, M
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2023-08-03T06:33:22Z
dc.date.available	2023-08-03T06:33:22Z
dc.identifier.citation	Journal of Biochemical and Molecular Toxicology
dc.identifier.issn	1095-6670
dc.identifier.issn	1099-0461
dc.identifier.uri	http://hdl.handle.net/10453/171713
dc.description.abstract	<jats:title>Abstract</jats:title><jats:p>Inflammation is an essential immune response that helps fight infections and heal tissues. However, chronic inflammation has been linked to several diseases, including cancer, autoimmune disorders, cardiovascular diseases, and neurological disorders. This has increased interest in finding natural substances that can modulate the immune system inflammatory signaling pathways to prevent or treat these diseases. Luteolin is a flavonoid found in many fruits, vegetables, and herbs. It has been shown to have anti‐inflammatory effects by altering signaling pathways in immune cells. This review article discusses the current research on luteolin's role as a natural immune system modulator of inflammatory signaling mechanisms, such as its effects on nuclear factor‐kappa B, mitogen‐activated protein kinases, Janus kinase/signal transducer and activator of transcription, and inflammasome signaling processes. The safety profile of luteolin and its potential therapeutic uses in conditions linked to inflammation are also discussed. Overall, the data point to Luteolin's intriguing potential as a natural regulator of immune system inflammatory signaling processes. More research is needed to fully understand its mechanisms of action and possible therapeutic applications.</jats:p>
dc.language	en
dc.publisher	Wiley
dc.relation.ispartof	Journal of Biochemical and Molecular Toxicology
dc.relation.isbasedon	10.1002/jbt.23482
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Toxicology
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders
dc.type	Journal Article
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2023-08-03T06:33:21Z
pubs.publication-status	Published online

Abstract:

AbstractInflammation is an essential immune response that helps fight infections and heal tissues. However, chronic inflammation has been linked to several diseases, including cancer, autoimmune disorders, cardiovascular diseases, and neurological disorders. This has increased interest in finding natural substances that can modulate the immune system inflammatory signaling pathways to prevent or treat these diseases. Luteolin is a flavonoid found in many fruits, vegetables, and herbs. It has been shown to have anti‐inflammatory effects by altering signaling pathways in immune cells. This review article discusses the current research on luteolin's role as a natural immune system modulator of inflammatory signaling mechanisms, such as its effects on nuclear factor‐kappa B, mitogen‐activated protein kinases, Janus kinase/signal transducer and activator of transcription, and inflammasome signaling processes. The safety profile of luteolin and its potential therapeutic uses in conditions linked to inflammation are also discussed. Overall, the data point to Luteolin's intriguing potential as a natural regulator of immune system inflammatory signaling processes. More research is needed to fully understand its mechanisms of action and possible therapeutic applications.

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http://hdl.handle.net/10453/171713