Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: A systematic review.

Wallingford, CK; Kovilpillai, H; Jacobs, C; Turbitt, E; Primiero, CA; Young, M-A; Brockman, DG; Soyer, HP; McInerney-Leo, AM; Yanes, T

Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: A systematic review.

Wallingford, CK Kovilpillai, H Jacobs, C

Turbitt, E

Primiero, CA Young, M-A Brockman, DG Soyer, HP McInerney-Leo, AM Yanes, T

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Genet Med, 2023, 25, (1), pp. 1-11
Issue Date:: 2023-01

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Field	Value	Language
dc.contributor.author	Wallingford, CK
dc.contributor.author	Kovilpillai, H
dc.contributor.author	Jacobs, C https://orcid.org/0000-0002-9557-9080
dc.contributor.author	Turbitt, E https://orcid.org/0000-0002-6650-9702
dc.contributor.author	Primiero, CA
dc.contributor.author	Young, M-A
dc.contributor.author	Brockman, DG
dc.contributor.author	Soyer, HP
dc.contributor.author	McInerney-Leo, AM
dc.contributor.author	Yanes, T
dc.date.accessioned	2023-09-06T02:04:17Z
dc.date.available	2022-09-17
dc.date.available	2023-09-06T02:04:17Z
dc.date.issued	2023-01
dc.identifier.citation	Genet Med, 2023, 25, (1), pp. 1-11
dc.identifier.issn	1098-3600
dc.identifier.issn	1530-0366
dc.identifier.uri	http://hdl.handle.net/10453/171941
dc.description.abstract	PURPOSE: This study aimed to systematically review current models for communicating polygenic scores (PGS) and psycho-behavioral outcomes of receiving PGSs. METHODS: Original research on communicating PGSs and reporting on psycho-behavioral outcomes was included. Search terms were applied to 5 databases and were limited by date (2009-2021). RESULTS: In total, 28 articles, representing 17 studies in several disease settings were identified. There was limited consistency in PGS communication and evaluation/reporting of outcomes. Most studies (n = 14) presented risk in multiple ways (ie, numerically, verbally, and/or visually). Three studies provided personalized lifestyle advice and additional resources. Only 1 of 17 studies reported using behavior change theory to inform their PGS intervention. A total of 8 studies found no evidence of long-term negative psychosocial effects up to 12 months post result. Of 14 studies reporting on behavior, 9 found at least 1 favorable change after PGS receipt. When stratified by risk, 7 out of 9 studies found high PGS was associated with favorable changes including lifestyle, medication, and screening. Low-risk PGS was not associated with maladaptive behaviors (n = 4). CONCLUSION: PGS has the potential to benefit health behavior. High variability among studies emphasizes the need for developing standardized guidelines for communicating PGSs and evaluating psycho-behavioral outcomes. Our findings call for development of best communication practices and evidence-based interventions informed by behavior change theories.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Genet Med
dc.relation.isbasedon	10.1016/j.gim.2022.09.008
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0604 Genetics, 1103 Clinical Sciences
dc.subject.classification	Genetics & Heredity
dc.subject.classification	3105 Genetics
dc.subject.mesh	Humans
dc.subject.mesh	Health Behavior
dc.subject.mesh	Life Style
dc.subject.mesh	Communication
dc.subject.mesh	Humans
dc.subject.mesh	Communication
dc.subject.mesh	Health Behavior
dc.subject.mesh	Life Style
dc.subject.mesh	Humans
dc.subject.mesh	Health Behavior
dc.subject.mesh	Life Style
dc.subject.mesh	Communication
dc.title	Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: A systematic review.
dc.type	Journal Article
utslib.citation.volume	25
utslib.location.activity	United States
utslib.for	0604 Genetics
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Genetic Counselling
utslib.copyright.status	closed_access	*
dc.date.updated	2023-09-06T02:04:16Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	25
utslib.citation.issue	1

Abstract:

PURPOSE: This study aimed to systematically review current models for communicating polygenic scores (PGS) and psycho-behavioral outcomes of receiving PGSs. METHODS: Original research on communicating PGSs and reporting on psycho-behavioral outcomes was included. Search terms were applied to 5 databases and were limited by date (2009-2021). RESULTS: In total, 28 articles, representing 17 studies in several disease settings were identified. There was limited consistency in PGS communication and evaluation/reporting of outcomes. Most studies (n = 14) presented risk in multiple ways (ie, numerically, verbally, and/or visually). Three studies provided personalized lifestyle advice and additional resources. Only 1 of 17 studies reported using behavior change theory to inform their PGS intervention. A total of 8 studies found no evidence of long-term negative psychosocial effects up to 12 months post result. Of 14 studies reporting on behavior, 9 found at least 1 favorable change after PGS receipt. When stratified by risk, 7 out of 9 studies found high PGS was associated with favorable changes including lifestyle, medication, and screening. Low-risk PGS was not associated with maladaptive behaviors (n = 4). CONCLUSION: PGS has the potential to benefit health behavior. High variability among studies emphasizes the need for developing standardized guidelines for communicating PGSs and evaluating psycho-behavioral outcomes. Our findings call for development of best communication practices and evidence-based interventions informed by behavior change theories.

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http://hdl.handle.net/10453/171941