Regular high-frequency whole blood donation and risk of cardiovascular disease in middle-aged and older blood donors in Australia.

Karki, S; Bell, KJL; Hayen, A; Liu, B; Cust, AE; Olynyk, JK; Irving, DO

Regular high-frequency whole blood donation and risk of cardiovascular disease in middle-aged and older blood donors in Australia.

Karki, S Bell, KJL Hayen, A

Liu, B Cust, AE Olynyk, JK Irving, DO

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Transfusion, 2023, 63, (5), pp. 1012-1022
Issue Date:: 2023-05

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Field	Value	Language
dc.contributor.author	Karki, S
dc.contributor.author	Bell, KJL
dc.contributor.author	Hayen, A https://orcid.org/0000-0003-4046-8030
dc.contributor.author	Liu, B
dc.contributor.author	Cust, AE
dc.contributor.author	Olynyk, JK
dc.contributor.author	Irving, DO
dc.date.accessioned	2023-09-12T05:50:02Z
dc.date.available	2023-02-22
dc.date.available	2023-09-12T05:50:02Z
dc.date.issued	2023-05
dc.identifier.citation	Transfusion, 2023, 63, (5), pp. 1012-1022
dc.identifier.issn	0041-1132
dc.identifier.issn	1537-2995
dc.identifier.uri	http://hdl.handle.net/10453/172063
dc.description.abstract	BACKGROUND: Previous mixed findings on the associations between whole blood (WB) donation and risk of cardiovascular diseases (CVD) may in part reflect inadequate adjustment for the "healthy donor effect" (HDE). METHODS: We used the Sax Institute's 45 and Up Study linked with blood donation history and other health-related databases to examine the association between regular, high-frequency WB donation and the risk of CVD. To mitigate the impact of HDE, we used a "5-years qualification period," in which donors must donate at least 1 WB donation in the 1st and 5th year of "qualification period." We then compared the risk of CVD in the years following the "qualification period" between the regular high-frequency WB donors (≥2 WB donation in each qualification year) and others using Cox proportional-hazards models. Analyses were adjusted for potential confounders, such as sociodemographic, lifestyle, and health-related variables, and results are reported separately for male and female donors. RESULTS: A total of 2736 male and 2917 female donors were included in the analyses. The median years of follow-up per donor was 5.84 years (Q1-Q3, 5.47-6.23). The rate of CVD hospitalization was 11.20 and 4.50 per 1000 person-years for males and females, respectively. In fully adjusted models, the risk (hazard ratio) of CVD in regular high-frequency donors compared to other donors was 0.93 (95% Confidence Interval (CI), 0.68-1.29) for males and 0.79 (95% CI, 0.49-1.28) for females. CONCLUSIONS: We did not observe a statistically significant reduction of CVD risk in regular, high-frequency WB donors when adjusted for potential confounders.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Transfusion
dc.relation.isbasedon	10.1111/trf.17358
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1107 Immunology
dc.subject.classification	Cardiovascular System & Hematology
dc.subject.classification	3201 Cardiovascular medicine and haematology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3204 Immunology
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Aged
dc.subject.mesh	Blood Donation
dc.subject.mesh	Blood Donors
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Australia
dc.subject.mesh	Databases, Factual
dc.subject.mesh	Humans
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Databases, Factual
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Blood Donors
dc.subject.mesh	Australia
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Blood Donation
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Aged
dc.subject.mesh	Blood Donation
dc.subject.mesh	Blood Donors
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Australia
dc.subject.mesh	Databases, Factual
dc.title	Regular high-frequency whole blood donation and risk of cardiovascular disease in middle-aged and older blood donors in Australia.
dc.type	Journal Article
utslib.citation.volume	63
utslib.location.activity	United States
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1103 Clinical Sciences
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
dc.date.updated	2023-09-12T05:50:01Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	63
utslib.citation.issue	5

Abstract:

BACKGROUND: Previous mixed findings on the associations between whole blood (WB) donation and risk of cardiovascular diseases (CVD) may in part reflect inadequate adjustment for the "healthy donor effect" (HDE). METHODS: We used the Sax Institute's 45 and Up Study linked with blood donation history and other health-related databases to examine the association between regular, high-frequency WB donation and the risk of CVD. To mitigate the impact of HDE, we used a "5-years qualification period," in which donors must donate at least 1 WB donation in the 1st and 5th year of "qualification period." We then compared the risk of CVD in the years following the "qualification period" between the regular high-frequency WB donors (≥2 WB donation in each qualification year) and others using Cox proportional-hazards models. Analyses were adjusted for potential confounders, such as sociodemographic, lifestyle, and health-related variables, and results are reported separately for male and female donors. RESULTS: A total of 2736 male and 2917 female donors were included in the analyses. The median years of follow-up per donor was 5.84 years (Q1-Q3, 5.47-6.23). The rate of CVD hospitalization was 11.20 and 4.50 per 1000 person-years for males and females, respectively. In fully adjusted models, the risk (hazard ratio) of CVD in regular high-frequency donors compared to other donors was 0.93 (95% Confidence Interval (CI), 0.68-1.29) for males and 0.79 (95% CI, 0.49-1.28) for females. CONCLUSIONS: We did not observe a statistically significant reduction of CVD risk in regular, high-frequency WB donors when adjusted for potential confounders.

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http://hdl.handle.net/10453/172063