The prevalence of insomnia in multiple sclerosis: A meta-analysis.

Zeng, X; Dorstyn, DS; Edwards, G; Kneebone, I

The prevalence of insomnia in multiple sclerosis: A meta-analysis.

Zeng, X Dorstyn, DS Edwards, G Kneebone, I

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Sleep Med Rev, 2023, 72, pp. 101842
Issue Date:: 2023-08-25

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Field	Value	Language
dc.contributor.author	Zeng, X
dc.contributor.author	Dorstyn, DS
dc.contributor.author	Edwards, G
dc.contributor.author	Kneebone, I https://orcid.org/0000-0003-3324-7264
dc.date.accessioned	2023-09-14T00:14:27Z
dc.date.available	2023-08-21
dc.date.available	2023-09-14T00:14:27Z
dc.date.issued	2023-08-25
dc.identifier.citation	Sleep Med Rev, 2023, 72, pp. 101842
dc.identifier.issn	1087-0792
dc.identifier.issn	1532-2955
dc.identifier.uri	http://hdl.handle.net/10453/172085
dc.description.abstract	Insomnia is a common complaint for adults with multiple sclerosis and can severely impact health-related quality of life. Point prevalence estimates of insomnia are, however, difficult to determine in this population due to the use of different measurement tools as well as the highly variable clinical presentation of multiple sclerosis. This review consolidates the current evidence base to provide a global estimate of insomnia disorders and symptoms in multiple sclerosis, with consideration of both measurement and sample issues. A comprehensive review of the PUBMED, EMBASE, PsycINFO and CINAHL databases from database inception until January 31st, 2023 identified 1649 records, of which 34 (7636 participants total) were eligible for inclusion. Findings were meta-analysed using a random-effects model. Estimates based on self-reported symptoms (52%, CI: 44%-59%) were significantly higher than those obtained by diagnostic tools (22%, CI: 16%-29%). Gender was identified as a potential moderator, with women more likely to report insomnia than men. One in two adults with multiple sclerosis endorse symptoms of poor sleep quality and daytime sleepiness, with 1 in 5 diagnosed with an insomnia disorder. Future research is needed to enhance understanding of these comorbid conditions, including the trajectory of insomnia with disease progression. PROSPERO registration number CRD42021281524.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Sleep Med Rev
dc.relation.isbasedon	10.1016/j.smrv.2023.101842
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.classification	52 Psychology
dc.title	The prevalence of insomnia in multiple sclerosis: A meta-analysis.
dc.type	Journal Article
utslib.citation.volume	72
utslib.location.activity	England
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Clinical Psychology
utslib.copyright.status	embargoed	*
utslib.copyright.embargo	2024-08-01T00:00:00+1000Z
dc.date.updated	2023-09-14T00:14:26Z
pubs.publication-status	Published online
pubs.volume	72

Abstract:

Insomnia is a common complaint for adults with multiple sclerosis and can severely impact health-related quality of life. Point prevalence estimates of insomnia are, however, difficult to determine in this population due to the use of different measurement tools as well as the highly variable clinical presentation of multiple sclerosis. This review consolidates the current evidence base to provide a global estimate of insomnia disorders and symptoms in multiple sclerosis, with consideration of both measurement and sample issues. A comprehensive review of the PUBMED, EMBASE, PsycINFO and CINAHL databases from database inception until January 31st, 2023 identified 1649 records, of which 34 (7636 participants total) were eligible for inclusion. Findings were meta-analysed using a random-effects model. Estimates based on self-reported symptoms (52%, CI: 44%-59%) were significantly higher than those obtained by diagnostic tools (22%, CI: 16%-29%). Gender was identified as a potential moderator, with women more likely to report insomnia than men. One in two adults with multiple sclerosis endorse symptoms of poor sleep quality and daytime sleepiness, with 1 in 5 diagnosed with an insomnia disorder. Future research is needed to enhance understanding of these comorbid conditions, including the trajectory of insomnia with disease progression. PROSPERO registration number CRD42021281524.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/172085