Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children

Hodge, L; Salome, CM; Hughes, JM; Liu-Brennan, D; Rimmer, J; Allman, M; Pang, D; Armour, C; Woolcock, AJ

Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children

Hodge, L Salome, CM Hughes, JM Liu-Brennan, D Rimmer, J Allman, M Pang, D Armour, C Woolcock, AJ

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Publisher:: MUNKSGAARD INT PUBL LTD
Publication Type:: Journal Article
Citation:: European Respiratory Journal, 1998, 11, (2), pp. 361-365
Issue Date:: 1998-02-01

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Field	Value	Language
dc.contributor.author	Hodge, L
dc.contributor.author	Salome, CM
dc.contributor.author	Hughes, JM
dc.contributor.author	Liu-Brennan, D
dc.contributor.author	Rimmer, J
dc.contributor.author	Allman, M
dc.contributor.author	Pang, D
dc.contributor.author	Armour, C
dc.contributor.author	Woolcock, AJ
dc.date.accessioned	2023-10-17T05:31:11Z
dc.date.available	2023-10-17T05:31:11Z
dc.date.issued	1998-02-01
dc.identifier.citation	European Respiratory Journal, 1998, 11, (2), pp. 361-365
dc.identifier.issn	0903-1936
dc.identifier.issn	1399-3003
dc.identifier.uri	http://hdl.handle.net/10453/172737
dc.description.abstract	We assessed the clinical and biochemical effects in asthmatic children of fish oil supplementation and a diet that increases omega-3 and reduces omega-6 fatty acids. Thirty nine asthmatic children aged 8-12 yrs participated in a double-blind, randomized, controlled trial for 6 months during which they received fish oil capsules plus canola oil and margarine (omega-3 group) or safflower oil capsules plus sunflower oil and margarine (omega-6 group). Plasma fatty acids, stimulated tumour necrosis factor α (TNFα) production, circulating eosinophil numbers and lung function were measured at baseline and after 3 and 6 months of dietary modification. Day and night symptoms, peak flow rates and medication use were recorded for 1 week prior to laboratory visits. Plasma phospholipid omega-3 fatty acids were significantly greater in the omega-3 group at 3 and 6 months compared to the omega-6 group (p < 0.001). In the omega-3 group TNFα production fell significantly compared with baseline (p = 0.026), but the magnitude of change between groups did not reach significance (p = 0.075). There were no significant changes in clinical outcome measures. Dietary enrichment of omega-3 fatty acids over 6 months increased plasma levels of these fatty acids, reduced stimulated tumour necrosis factor α production, but had no effect on the clinical severity of asthma in these children.
dc.format	Print
dc.language	eng
dc.publisher	MUNKSGAARD INT PUBL LTD
dc.relation.ispartof	European Respiratory Journal
dc.relation.isbasedon	10.1183/09031936.98.11020361
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences, 1116 Medical Physiology
dc.subject.classification	Respiratory System
dc.subject.classification	3201 Cardiovascular medicine and haematology
dc.subject.mesh	Asthma
dc.subject.mesh	Blood Cell Count
dc.subject.mesh	Child
dc.subject.mesh	Dietary Fats
dc.subject.mesh	Eosinophils
dc.subject.mesh	Fatty Acids, Omega-3
dc.subject.mesh	Fatty Acids, Omega-6
dc.subject.mesh	Fatty Acids, Unsaturated
dc.subject.mesh	Forced Expiratory Volume
dc.subject.mesh	Humans
dc.subject.mesh	Lung
dc.subject.mesh	Monocytes
dc.subject.mesh	Tumor Necrosis Factor-alpha
dc.subject.mesh	Lung
dc.subject.mesh	Eosinophils
dc.subject.mesh	Monocytes
dc.subject.mesh	Humans
dc.subject.mesh	Asthma
dc.subject.mesh	Dietary Fats
dc.subject.mesh	Fatty Acids, Omega-3
dc.subject.mesh	Fatty Acids, Unsaturated
dc.subject.mesh	Fatty Acids, Omega-6
dc.subject.mesh	Tumor Necrosis Factor-alpha
dc.subject.mesh	Forced Expiratory Volume
dc.subject.mesh	Blood Cell Count
dc.subject.mesh	Child
dc.subject.mesh	Asthma
dc.subject.mesh	Blood Cell Count
dc.subject.mesh	Child
dc.subject.mesh	Dietary Fats
dc.subject.mesh	Eosinophils
dc.subject.mesh	Fatty Acids, Omega-3
dc.subject.mesh	Fatty Acids, Omega-6
dc.subject.mesh	Fatty Acids, Unsaturated
dc.subject.mesh	Forced Expiratory Volume
dc.subject.mesh	Humans
dc.subject.mesh	Lung
dc.subject.mesh	Monocytes
dc.subject.mesh	Tumor Necrosis Factor-alpha
dc.title	Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	England
utslib.for	11 Medical and Health Sciences
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Australian Stuttering Research Centre
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2023-10-17T05:31:10Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	11
utslib.citation.issue	2

Abstract:

We assessed the clinical and biochemical effects in asthmatic children of fish oil supplementation and a diet that increases omega-3 and reduces omega-6 fatty acids. Thirty nine asthmatic children aged 8-12 yrs participated in a double-blind, randomized, controlled trial for 6 months during which they received fish oil capsules plus canola oil and margarine (omega-3 group) or safflower oil capsules plus sunflower oil and margarine (omega-6 group). Plasma fatty acids, stimulated tumour necrosis factor α (TNFα) production, circulating eosinophil numbers and lung function were measured at baseline and after 3 and 6 months of dietary modification. Day and night symptoms, peak flow rates and medication use were recorded for 1 week prior to laboratory visits. Plasma phospholipid omega-3 fatty acids were significantly greater in the omega-3 group at 3 and 6 months compared to the omega-6 group (p < 0.001). In the omega-3 group TNFα production fell significantly compared with baseline (p = 0.026), but the magnitude of change between groups did not reach significance (p = 0.075). There were no significant changes in clinical outcome measures. Dietary enrichment of omega-3 fatty acids over 6 months increased plasma levels of these fatty acids, reduced stimulated tumour necrosis factor α production, but had no effect on the clinical severity of asthma in these children.

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http://hdl.handle.net/10453/172737