2-Hexyl-4-Pentylenic Acid (HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages.

Duan, WH; Jin, LY; Cai, ZC; Lim, D; Feng, ZH

2-Hexyl-4-Pentylenic Acid (HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages.

Duan, WH Jin, LY Cai, ZC Lim, D Feng, ZH

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Publisher:: CHINESE CENTER DISEASE CONTROL & PREVENTION
Publication Type:: Journal Article
Citation:: Biomed Environ Sci, 2021, 34, (9), pp. 693-704
Issue Date:: 2021-09-20

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Field	Value	Language
dc.contributor.author	Duan, WH
dc.contributor.author	Jin, LY
dc.contributor.author	Cai, ZC
dc.contributor.author	Lim, D
dc.contributor.author	Feng, ZH
dc.date.accessioned	2023-10-25T23:32:59Z
dc.date.available	2021-03-09
dc.date.available	2023-10-25T23:32:59Z
dc.date.issued	2021-09-20
dc.identifier.citation	Biomed Environ Sci, 2021, 34, (9), pp. 693-704
dc.identifier.issn	0895-3988
dc.identifier.issn	2214-0190
dc.identifier.uri	http://hdl.handle.net/10453/172853
dc.description.abstract	OBJECTIVE: The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid (HPTA) in combination with radiotherapy (RT) on distant unirradiated breast tumors. METHODS: Using a rat model of chemical carcinogen (7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer, tumor volume was monitored and treatment response was evaluated by performing HE staining, immunohistochemistry, immunofluorescence, qRT-PCR, and western blot analyses. RESULTS: The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant, unirradiated breast tumors. The mechanism of action included tumor-associated macrophage (TAM) infiltration into distant tumor tissues, M1 polarization, and inhibition of tumor angiogenesis by IFN-γ. CONCLUSION: The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors via M1-polarized TAMs, and HPTA may be considered as a new therapeutic for amplifying the efficacy of local RT for non-targeted breast tumors. UNLABELLED: The graphical abstract was available in the web of www.besjournal.com.
dc.format	Print
dc.language	eng
dc.publisher	CHINESE CENTER DISEASE CONTROL & PREVENTION
dc.relation.ispartof	Biomed Environ Sci
dc.relation.isbasedon	10.3967/bes2021.097
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Toxicology
dc.subject.classification	4202 Epidemiology
dc.subject.classification	4206 Public health
dc.subject.mesh	Animals
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Combined Modality Therapy
dc.subject.mesh	Cytokines
dc.subject.mesh	Fatty Acids, Unsaturated
dc.subject.mesh	Female
dc.subject.mesh	Mammary Neoplasms, Experimental
dc.subject.mesh	Rats
dc.subject.mesh	Tumor-Associated Macrophages
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Mammary Neoplasms, Experimental
dc.subject.mesh	Fatty Acids, Unsaturated
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Cytokines
dc.subject.mesh	Combined Modality Therapy
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Female
dc.subject.mesh	Tumor-Associated Macrophages
dc.subject.mesh	Animals
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Combined Modality Therapy
dc.subject.mesh	Cytokines
dc.subject.mesh	Fatty Acids, Unsaturated
dc.subject.mesh	Female
dc.subject.mesh	Mammary Neoplasms, Experimental
dc.subject.mesh	Rats
dc.subject.mesh	Tumor-Associated Macrophages
dc.title	2-Hexyl-4-Pentylenic Acid (HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	China
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
dc.date.updated	2023-10-25T23:32:57Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	9

Abstract:

OBJECTIVE: The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid (HPTA) in combination with radiotherapy (RT) on distant unirradiated breast tumors. METHODS: Using a rat model of chemical carcinogen (7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer, tumor volume was monitored and treatment response was evaluated by performing HE staining, immunohistochemistry, immunofluorescence, qRT-PCR, and western blot analyses. RESULTS: The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant, unirradiated breast tumors. The mechanism of action included tumor-associated macrophage (TAM) infiltration into distant tumor tissues, M1 polarization, and inhibition of tumor angiogenesis by IFN-γ. CONCLUSION: The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors via M1-polarized TAMs, and HPTA may be considered as a new therapeutic for amplifying the efficacy of local RT for non-targeted breast tumors. UNLABELLED: The graphical abstract was available in the web of www.besjournal.com.

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http://hdl.handle.net/10453/172853