Sensory Processing in Children and Adolescents with Neurofibromatosis Type 1.

Pride, NA; Haebich, KM; Walsh, KS; Lami, F; Rouel, M; Maier, A; Chisholm, AK; Lorenzo, J; Hearps, SJC; North, KN; Payne, JM

Sensory Processing in Children and Adolescents with Neurofibromatosis Type 1.

Pride, NA Haebich, KM Walsh, KS Lami, F Rouel, M

Maier, A Chisholm, AK Lorenzo, J Hearps, SJC North, KN Payne, JM

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Cancers (Basel), 2023, 15, (14), pp. 3612
Issue Date:: 2023-07-14

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Field	Value	Language
dc.contributor.author	Pride, NA
dc.contributor.author	Haebich, KM
dc.contributor.author	Walsh, KS
dc.contributor.author	Lami, F
dc.contributor.author	Rouel, M https://orcid.org/0000-0002-2346-6247
dc.contributor.author	Maier, A
dc.contributor.author	Chisholm, AK
dc.contributor.author	Lorenzo, J
dc.contributor.author	Hearps, SJC
dc.contributor.author	North, KN
dc.contributor.author	Payne, JM
dc.date.accessioned	2023-11-06T23:57:32Z
dc.date.available	2023-07-12
dc.date.available	2023-11-06T23:57:32Z
dc.date.issued	2023-07-14
dc.identifier.citation	Cancers (Basel), 2023, 15, (14), pp. 3612
dc.identifier.issn	2072-6694
dc.identifier.issn	2072-6694
dc.identifier.uri	http://hdl.handle.net/10453/173108
dc.description.abstract	Despite the evidence of elevated autistic behaviors and co-occurring neurodevelopmental difficulties in many children with neurofibromatosis type 1 (NF1), we have a limited understanding of the sensory processing challenges that may occur with the condition. This study examined the sensory profile of children and adolescents with NF1 and investigated the relationships between the sensory profiles and patient characteristics and neuropsychological functioning. The parent/caregivers of 152 children with NF1 and 96 typically developing children completed the Sensory Profile 2 (SP2), along with standardized questionnaires assessing autistic behaviors, ADHD symptoms, internalizing symptoms, adaptive functioning, and social skills. Intellectual functioning was also assessed. The SP2 data indicated elevated sensory processing problems in children with NF1 compared to typically developing children. Over 40% of children with NF1 displayed differences in sensory registration (missing sensory input) and were unusually sensitive to and unusually avoidant of sensory stimuli. Sixty percent of children with NF1 displayed difficulties in one or more sensory modalities. Elevated autistic behaviors and ADHD symptoms were associated with more severe sensory processing difficulties. This first detailed assessment of sensory processing, alongside other clinical features, in a relatively large cohort of children and adolescents with NF1 demonstrates the relationships between sensory processing differences and adaptive skills and behavior, as well as psychological well-being. Our characterization of the sensory profile within a genetic syndrome may help facilitate more targeted interventions to support overall functioning.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Cancers (Basel)
dc.relation.isbasedon	10.3390/cancers15143612
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1112 Oncology and Carcinogenesis
dc.subject.classification	3211 Oncology and carcinogenesis
dc.title	Sensory Processing in Children and Adolescents with Neurofibromatosis Type 1.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	Switzerland
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Clinical Psychology
utslib.copyright.status	open_access	*
dc.date.updated	2023-11-06T23:57:31Z
pubs.issue	14
pubs.publication-status	Published online
pubs.volume	15
utslib.citation.issue	14

Abstract:

Despite the evidence of elevated autistic behaviors and co-occurring neurodevelopmental difficulties in many children with neurofibromatosis type 1 (NF1), we have a limited understanding of the sensory processing challenges that may occur with the condition. This study examined the sensory profile of children and adolescents with NF1 and investigated the relationships between the sensory profiles and patient characteristics and neuropsychological functioning. The parent/caregivers of 152 children with NF1 and 96 typically developing children completed the Sensory Profile 2 (SP2), along with standardized questionnaires assessing autistic behaviors, ADHD symptoms, internalizing symptoms, adaptive functioning, and social skills. Intellectual functioning was also assessed. The SP2 data indicated elevated sensory processing problems in children with NF1 compared to typically developing children. Over 40% of children with NF1 displayed differences in sensory registration (missing sensory input) and were unusually sensitive to and unusually avoidant of sensory stimuli. Sixty percent of children with NF1 displayed difficulties in one or more sensory modalities. Elevated autistic behaviors and ADHD symptoms were associated with more severe sensory processing difficulties. This first detailed assessment of sensory processing, alongside other clinical features, in a relatively large cohort of children and adolescents with NF1 demonstrates the relationships between sensory processing differences and adaptive skills and behavior, as well as psychological well-being. Our characterization of the sensory profile within a genetic syndrome may help facilitate more targeted interventions to support overall functioning.

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http://hdl.handle.net/10453/173108