Which breathlessness dimensions associate most strongly with fatigue?-The population-based VASCOL study of elderly men.

Cristea, L; Olsson, M; Sandberg, J; Kochovska, S; Currow, D; Ekström, M

Which breathlessness dimensions associate most strongly with fatigue?-The population-based VASCOL study of elderly men.

Cristea, L Olsson, M Sandberg, J Kochovska, S

Currow, D

Ekström, M

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Publisher:: Public Library of Science (PLoS)
Publication Type:: Journal Article
Citation:: PLoS One, 2023, 18, (12), pp. e0296016
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Cristea, L
dc.contributor.author	Olsson, M
dc.contributor.author	Sandberg, J
dc.contributor.author	Kochovska, S https://orcid.org/0000-0002-3531-0389
dc.contributor.author	Currow, D https://orcid.org/0000-0003-1988-1250
dc.contributor.author	Ekström, M
dc.contributor.editor	Samaranayaka, A
dc.date.accessioned	2024-01-09T04:36:24Z
dc.date.available	2023-12-04
dc.date.available	2024-01-09T04:36:24Z
dc.date.issued	2023
dc.identifier.citation	PLoS One, 2023, 18, (12), pp. e0296016
dc.identifier.issn	1932-6203
dc.identifier.issn	1932-6203
dc.identifier.uri	http://hdl.handle.net/10453/174143
dc.description.abstract	BACKGROUND: Breathlessness and fatigue are common symptoms in older people. We aimed to evaluate how different breathlessness dimensions (overall intensity, unpleasantness, sensory descriptors, emotional responses) were associated with fatigue in elderly men. METHODS: This was a cross-sectional analysis of the population-based VAScular disease and Chronic Obstructive Lung Disease (VASCOL) study of 73-year old men. Breathlessness dimensions were assessed using the Dyspnoea-12 (D-12), Multidimensional Dyspnoea Profile (MDP), and the modified Medical Research Council (mMRC) scale. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire. Clinically relevant fatigue was defined as FACIT-F≤ 30 units. Scores were compared standardized as z-scores and analysed using linear regression, adjusted for body mass index, smoking, depression, cancer, sleep apnoea, prior cardiac surgery, respiratory and cardiovascular disease. RESULTS: Of 677 participants, 11.7% had clinically relevant fatigue. Higher breathlessness scores were associated with having worse fatigue; for D-12 total, -0.35 ([95% CI] -0.41 to -0.30) and for MDP A1, -0.24 (-0.30 to -0.18). Associations were similar across all the evaluated breathlessness dimensions even when adjusting for the potential confounders. CONCLUSION: Breathlessness assessed using D-12 and MDP was associated with worse fatigue in elderly men, similarly across different breathlessness dimensions.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation.ispartof	PLoS One
dc.relation.isbasedon	10.1371/journal.pone.0296016
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	General Science & Technology
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Aged
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Dyspnea
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Fatigue
dc.subject.mesh	Humans
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Dyspnea
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Fatigue
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Aged
dc.subject.mesh	Male
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Aged
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Dyspnea
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Fatigue
dc.title	Which breathlessness dimensions associate most strongly with fatigue?-The population-based VASCOL study of elderly men.
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-09T04:36:23Z
pubs.issue	12
pubs.publication-status	Published online
pubs.volume	18
utslib.citation.issue	12

Abstract:

BACKGROUND: Breathlessness and fatigue are common symptoms in older people. We aimed to evaluate how different breathlessness dimensions (overall intensity, unpleasantness, sensory descriptors, emotional responses) were associated with fatigue in elderly men. METHODS: This was a cross-sectional analysis of the population-based VAScular disease and Chronic Obstructive Lung Disease (VASCOL) study of 73-year old men. Breathlessness dimensions were assessed using the Dyspnoea-12 (D-12), Multidimensional Dyspnoea Profile (MDP), and the modified Medical Research Council (mMRC) scale. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire. Clinically relevant fatigue was defined as FACIT-F≤ 30 units. Scores were compared standardized as z-scores and analysed using linear regression, adjusted for body mass index, smoking, depression, cancer, sleep apnoea, prior cardiac surgery, respiratory and cardiovascular disease. RESULTS: Of 677 participants, 11.7% had clinically relevant fatigue. Higher breathlessness scores were associated with having worse fatigue; for D-12 total, -0.35 ([95% CI] -0.41 to -0.30) and for MDP A1, -0.24 (-0.30 to -0.18). Associations were similar across all the evaluated breathlessness dimensions even when adjusting for the potential confounders. CONCLUSION: Breathlessness assessed using D-12 and MDP was associated with worse fatigue in elderly men, similarly across different breathlessness dimensions.

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http://hdl.handle.net/10453/174143