Effect of exercise therapy in patients with hip osteoarthritis: A systematic review and cumulative meta-analysis.

Teirlinck, CH; Verhagen, AP; van Ravesteyn, LM; Reijneveld-van de Vendel, EAE; Runhaar, J; van Middelkoop, M; Ferreira, ML; Bierma-Zeinstra, SM

Effect of exercise therapy in patients with hip osteoarthritis: A systematic review and cumulative meta-analysis.

Teirlinck, CH Verhagen, AP van Ravesteyn, LM Reijneveld-van de Vendel, EAE Runhaar, J van Middelkoop, M Ferreira, ML Bierma-Zeinstra, SM

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Osteoarthr Cartil Open, 2023, 5, (1), pp. 100338
Issue Date:: 2023-03

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Field	Value	Language
dc.contributor.author	Teirlinck, CH
dc.contributor.author	Verhagen, AP
dc.contributor.author	van Ravesteyn, LM
dc.contributor.author	Reijneveld-van de Vendel, EAE
dc.contributor.author	Runhaar, J
dc.contributor.author	van Middelkoop, M
dc.contributor.author	Ferreira, ML
dc.contributor.author	Bierma-Zeinstra, SM
dc.date.accessioned	2024-01-12T03:58:38Z
dc.date.available	2023-01-12
dc.date.available	2024-01-12T03:58:38Z
dc.date.issued	2023-03
dc.identifier.citation	Osteoarthr Cartil Open, 2023, 5, (1), pp. 100338
dc.identifier.issn	2665-9131
dc.identifier.issn	2665-9131
dc.identifier.uri	http://hdl.handle.net/10453/174360
dc.description.abstract	OBJECTIVE: To evaluate the existing evidence on the effect of exercise therapy in patients with hip osteoarthritis (OA) compared to no treatment and explore whether a further trial will change the current evidence. DESIGN: Systematic review and cumulative meta-analysis using randomized controlled trials (RCT) to determine the effect on pain and function post-treatment, and at 6-9 months after treatment. Standardized mean difference (SMD) ≤ -0.37 was considered clinically worthwhile. Extended funnel plots were used to simulate the impact of a new trial on the pooled effect size of pain and function. RESULTS: 18 RCTs were included. Post-treatment we found a beneficial effect of exercise therapy on pain (SMD -0.38, 95% Confidence Interval (CI): 0.55 to -0.22) and function (SMD -0.31, 95% CI -0.49 to -0.11). A beneficial effect of exercise therapy on pain (SMD -0.23, 95% CI: 0.41 to -0.05) and function (SMD -0.29, 95% CI: 0.45 to -0.12) was found 6-9 months after treatment. Most effect estimates were small, and it is unclear whether these are clinically meaningful. Extended funnel plots and a simulation of a new trial showed that only a new trial with a larger effect than the current pooled effect or a trial including 74,843 participants would change the pooled effect estimate from an unclear to a clearly clinically worthwhile effect. CONCLUSIONS: We found a beneficial effect of exercise therapy on pain and function in hip OA. It is unlikely a new trial added to current evidence will change the conclusion.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Osteoarthr Cartil Open
dc.relation.isbasedon	10.1016/j.ocarto.2023.100338
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.subject.classification	3202 Clinical sciences
dc.title	Effect of exercise therapy in patients with hip osteoarthritis: A systematic review and cumulative meta-analysis.
dc.type	Journal Article
utslib.citation.volume	5
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Physiotherapy
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-12T03:58:34Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	5
utslib.citation.issue	1

Abstract:

OBJECTIVE: To evaluate the existing evidence on the effect of exercise therapy in patients with hip osteoarthritis (OA) compared to no treatment and explore whether a further trial will change the current evidence. DESIGN: Systematic review and cumulative meta-analysis using randomized controlled trials (RCT) to determine the effect on pain and function post-treatment, and at 6-9 months after treatment. Standardized mean difference (SMD) ≤ -0.37 was considered clinically worthwhile. Extended funnel plots were used to simulate the impact of a new trial on the pooled effect size of pain and function. RESULTS: 18 RCTs were included. Post-treatment we found a beneficial effect of exercise therapy on pain (SMD -0.38, 95% Confidence Interval (CI): 0.55 to -0.22) and function (SMD -0.31, 95% CI -0.49 to -0.11). A beneficial effect of exercise therapy on pain (SMD -0.23, 95% CI: 0.41 to -0.05) and function (SMD -0.29, 95% CI: 0.45 to -0.12) was found 6-9 months after treatment. Most effect estimates were small, and it is unclear whether these are clinically meaningful. Extended funnel plots and a simulation of a new trial showed that only a new trial with a larger effect than the current pooled effect or a trial including 74,843 participants would change the pooled effect estimate from an unclear to a clearly clinically worthwhile effect. CONCLUSIONS: We found a beneficial effect of exercise therapy on pain and function in hip OA. It is unlikely a new trial added to current evidence will change the conclusion.

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http://hdl.handle.net/10453/174360