Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies.

Chung, H-F; Dobson, AJ; Hayashi, K; Hardy, R; Kuh, D; Anderson, DJ; van der Schouw, YT; Greenwood, DC; Cade, JE; Demakakos, P; Brunner, EJ; Eastwood, SV; Sandin, S; Weiderpass, E; Mishra, GD

Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies.

Chung, H-F Dobson, AJ Hayashi, K Hardy, R Kuh, D Anderson, DJ van der Schouw, YT Greenwood, DC Cade, JE Demakakos, P Brunner, EJ Eastwood, SV Sandin, S Weiderpass, E Mishra, GD

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Publisher:: American Diabetes Association
Publication Type:: Journal Article
Citation:: Diabetes Care, 2023, 46, (11), pp. 2024-2034
Issue Date:: 2023-11-01

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Field	Value	Language
dc.contributor.author	Chung, H-F
dc.contributor.author	Dobson, AJ
dc.contributor.author	Hayashi, K
dc.contributor.author	Hardy, R
dc.contributor.author	Kuh, D
dc.contributor.author	Anderson, DJ
dc.contributor.author	van der Schouw, YT
dc.contributor.author	Greenwood, DC
dc.contributor.author	Cade, JE
dc.contributor.author	Demakakos, P
dc.contributor.author	Brunner, EJ
dc.contributor.author	Eastwood, SV
dc.contributor.author	Sandin, S
dc.contributor.author	Weiderpass, E
dc.contributor.author	Mishra, GD
dc.date.accessioned	2024-01-29T03:47:50Z
dc.date.available	2023-08-19
dc.date.available	2024-01-29T03:47:50Z
dc.date.issued	2023-11-01
dc.identifier.citation	Diabetes Care, 2023, 46, (11), pp. 2024-2034
dc.identifier.issn	0149-5992
dc.identifier.issn	1935-5548
dc.identifier.uri	http://hdl.handle.net/10453/174998
dc.description.abstract	OBJECTIVE: To investigate associations between age at natural menopause, particularly premature ovarian insufficiency (POI) (natural menopause before age 40 years), and incident type 2 diabetes (T2D) and identify any variations by ethnicity. RESEARCH DESIGN AND METHODS: We pooled individual-level data of 338,059 women from 13 cohort studies without T2D before menopause from six ethnic groups: White (n = 177,674), Chinese (n = 146,008), Japanese (n = 9,061), South/Southeast Asian (n = 2,228), Black (n = 1,838), and mixed/other (n = 1,250). Hazard ratios (HRs) of T2D associated with age at menopause were estimated in the overall sample and by ethnicity, with study as a random effect. For each ethnic group, we further stratified the association by birth year, education level, and BMI. RESULTS: Over 9 years of follow-up, 20,064 (5.9%) women developed T2D. Overall, POI (vs. menopause at age 50-51 years) was associated with an increased risk of T2D (HR 1.31; 95% CI 1.20-1.44), and there was an interaction between age at menopause and ethnicity (P < 0.0001). T2D risk associated with POI was higher in White (1.53; 1.36-1.73), Japanese (4.04; 1.97-8.27), and Chinese women born in 1950 or later (2.79; 2.11-3.70); although less precise, the risk estimates were consistent in women of South/Southeast Asian (1.46; 0.89-2.40), Black (1.72; 0.95-3.12), and mixed/other (2.16; 0.83-5.57) ethnic groups. A similar pattern, but with a smaller increased risk of T2D, was observed with early menopause overall (1.16; 1.10-1.23) and for White, Japanese, and Chinese women born in 1950 or later. CONCLUSIONS: POI and early menopause are risk factors for T2D in postmenopausal women, with considerable variation across ethnic groups, and may need to be considered in risk assessments of T2D among women.
dc.format	Print
dc.language	eng
dc.publisher	American Diabetes Association
dc.relation	http://purl.org/au-research/grants/nhmrc/1027196
dc.relation.ispartof	Diabetes Care
dc.relation.isbasedon	10.2337/dc23-1209
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Endocrinology & Metabolism
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Adult
dc.subject.mesh	Male
dc.subject.mesh	Diabetes Mellitus, Type 2
dc.subject.mesh	Postmenopause
dc.subject.mesh	Menopause
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Ethnicity
dc.subject.mesh	Menopause, Premature
dc.subject.mesh	Humans
dc.subject.mesh	Menopause, Premature
dc.subject.mesh	Diabetes Mellitus, Type 2
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Menopause
dc.subject.mesh	Postmenopause
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Ethnicity
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Adult
dc.subject.mesh	Male
dc.subject.mesh	Diabetes Mellitus, Type 2
dc.subject.mesh	Postmenopause
dc.subject.mesh	Menopause
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Ethnicity
dc.subject.mesh	Menopause, Premature
dc.title	Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies.
dc.type	Journal Article
utslib.citation.volume	46
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-29T03:47:49Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	46
utslib.citation.issue	11

Abstract:

OBJECTIVE: To investigate associations between age at natural menopause, particularly premature ovarian insufficiency (POI) (natural menopause before age 40 years), and incident type 2 diabetes (T2D) and identify any variations by ethnicity. RESEARCH DESIGN AND METHODS: We pooled individual-level data of 338,059 women from 13 cohort studies without T2D before menopause from six ethnic groups: White (n = 177,674), Chinese (n = 146,008), Japanese (n = 9,061), South/Southeast Asian (n = 2,228), Black (n = 1,838), and mixed/other (n = 1,250). Hazard ratios (HRs) of T2D associated with age at menopause were estimated in the overall sample and by ethnicity, with study as a random effect. For each ethnic group, we further stratified the association by birth year, education level, and BMI. RESULTS: Over 9 years of follow-up, 20,064 (5.9%) women developed T2D. Overall, POI (vs. menopause at age 50-51 years) was associated with an increased risk of T2D (HR 1.31; 95% CI 1.20-1.44), and there was an interaction between age at menopause and ethnicity (P < 0.0001). T2D risk associated with POI was higher in White (1.53; 1.36-1.73), Japanese (4.04; 1.97-8.27), and Chinese women born in 1950 or later (2.79; 2.11-3.70); although less precise, the risk estimates were consistent in women of South/Southeast Asian (1.46; 0.89-2.40), Black (1.72; 0.95-3.12), and mixed/other (2.16; 0.83-5.57) ethnic groups. A similar pattern, but with a smaller increased risk of T2D, was observed with early menopause overall (1.16; 1.10-1.23) and for White, Japanese, and Chinese women born in 1950 or later. CONCLUSIONS: POI and early menopause are risk factors for T2D in postmenopausal women, with considerable variation across ethnic groups, and may need to be considered in risk assessments of T2D among women.

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http://hdl.handle.net/10453/174998