Abstract 18365: Elevated Biomarkers of Subclinical Myocardial Injury and Inflammation Among Community-Dwelling Adults With Covid-19

Ogungbe, OV; deCardi Hladek, M; Sokoll, L; Mohr, P; Dennison Himmelfarb, CR; Davidson, P; Post, WS; Farley, J; Commodore-Mensah, Y

Abstract 18365: Elevated Biomarkers of Subclinical Myocardial Injury and Inflammation Among Community-Dwelling Adults With Covid-19

Ogungbe, OV deCardi Hladek, M Sokoll, L Mohr, P Dennison Himmelfarb, CR Davidson, P

Post, WS Farley, J Commodore-Mensah, Y

Permalink

Publisher:: Wolters Kluwer
Publication Type:: Journal Article
Citation:: Circulation, 2023, 148, (Suppl_1)
Issue Date:: 2023-11-07

Closed Access

	Filename	Description	Size
	Abstract 18365 - Elevated Biomarkers of Subclinical Myocardial Injury and Inflammation Among Community-Dwelling Adults With Covid-19.docx	Published version	324.82 kB	Microsoft Word	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Ogungbe, OV
dc.contributor.author	deCardi Hladek, M
dc.contributor.author	Sokoll, L
dc.contributor.author	Mohr, P
dc.contributor.author	Dennison Himmelfarb, CR
dc.contributor.author	Davidson, P https://orcid.org/0000-0003-2050-1534
dc.contributor.author	Post, WS
dc.contributor.author	Farley, J
dc.contributor.author	Commodore-Mensah, Y
dc.date.accessioned	2024-02-14T02:16:37Z
dc.date.available	2024-02-14T02:16:37Z
dc.date.issued	2023-11-07
dc.identifier.citation	Circulation, 2023, 148, (Suppl_1)
dc.identifier.issn	0009-7322
dc.identifier.issn	1524-4539
dc.identifier.uri	http://hdl.handle.net/10453/175668
dc.description.abstract	<jats:p> <jats:bold>Background:</jats:bold> Subclinical cardiovascular impact of SARS-CoV-2 infection in mild-moderate cases is unclear. <jats:bold>Hypothesis</jats:bold> We hypothesized that positive anti-nucleocapsid/spike SARS-CoV-2 antibodies will be associated with elevated subclinical cardiac and inflammatory biomarkers. </jats:p> <jats:p> <jats:bold>Methods:</jats:bold> This study was nested within a randomized controlled trial among community-dwelling adults. We used logistic regression to estimate adjusted odds of positive anti-nucleocapsid/ spike protein antibodies and elevated cardiac and inflammatory biomarkers (high-sensitivity cardiac troponin [hs-TnI], N-terminal pro-B-type natriuretic peptide [NT-proBNP], Galectin-3 [Gal-3], and C-reactive protein, [CRP]). </jats:p> <jats:p> <jats:bold>Results:</jats:bold> Among 231 adults, mean (±SD) age was 50 (±17.6) years, 63% were female, 57% were Black persons. Overall, 11% had detectable hs-cTnI (&ge;6 ng/L), 21% had elevated NT-proBNP (&ge;125pg/dL), 42% had elevated Gal-3 (&ge;18.5 ng/mL), 70% had elevated CRP (&ge;0.9 mg/dL). CRP levels were significantly higher among persons with positive spike protein antibodies [positive: median, 1.9 (Interquartile range IQR, 4.1) vs. negative: median, 0.7 (IQR, 2.1); p=0.014]. Those with positive spike protein antibodies were 3.49 (95% CI, 1.33-9.15) times more likely to have elevated CRP than those who were negative. Cardiac/inflammatory biomarkers were slightly higher in persons with positive SARS-CoV-2 IgG antibody detecting nucleocapsid protein (virus-specific antibody) versus negative ( <jats:bold>Figure</jats:bold> ). </jats:p> <jats:p> <jats:bold>Conclusions:</jats:bold> In this sample, we observed elevated cardiac and inflammatory biomarkers indicative of myocardial injury. Further research on the durability of elevated cardiac biomarkers and their contributions to post-acute sequela of COVID-19 is needed. </jats:p> <jats:p> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" orientation="portrait" position="float" xlink:href="g18365.jpg" /> </jats:p>
dc.language	en
dc.publisher	Wolters Kluwer
dc.relation.ispartof	Circulation
dc.relation.isbasedon	10.1161/circ.148.suppl_1.18365
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1117 Public Health and Health Services
dc.subject.classification	Cardiovascular System & Hematology
dc.subject.classification	3201 Cardiovascular medicine and haematology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	4207 Sports science and exercise
dc.title	Abstract 18365: Elevated Biomarkers of Subclinical Myocardial Injury and Inflammation Among Community-Dwelling Adults With Covid-19
dc.type	Journal Article
utslib.citation.volume	148
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
dc.date.updated	2024-02-14T02:16:36Z
pubs.issue	Suppl_1
pubs.publication-status	Published
pubs.volume	148
utslib.citation.issue	Suppl_1

Abstract:

Background: Subclinical cardiovascular impact of SARS-CoV-2 infection in mild-moderate cases is unclear. Hypothesis We hypothesized that positive anti-nucleocapsid/spike SARS-CoV-2 antibodies will be associated with elevated subclinical cardiac and inflammatory biomarkers. Methods: This study was nested within a randomized controlled trial among community-dwelling adults. We used logistic regression to estimate adjusted odds of positive anti-nucleocapsid/ spike protein antibodies and elevated cardiac and inflammatory biomarkers (high-sensitivity cardiac troponin [hs-TnI], N-terminal pro-B-type natriuretic peptide [NT-proBNP], Galectin-3 [Gal-3], and C-reactive protein, [CRP]). Results: Among 231 adults, mean (±SD) age was 50 (±17.6) years, 63% were female, 57% were Black persons. Overall, 11% had detectable hs-cTnI (≥6 ng/L), 21% had elevated NT-proBNP (≥125pg/dL), 42% had elevated Gal-3 (≥18.5 ng/mL), 70% had elevated CRP (≥0.9 mg/dL). CRP levels were significantly higher among persons with positive spike protein antibodies [positive: median, 1.9 (Interquartile range IQR, 4.1) vs. negative: median, 0.7 (IQR, 2.1); p=0.014]. Those with positive spike protein antibodies were 3.49 (95% CI, 1.33-9.15) times more likely to have elevated CRP than those who were negative. Cardiac/inflammatory biomarkers were slightly higher in persons with positive SARS-CoV-2 IgG antibody detecting nucleocapsid protein (virus-specific antibody) versus negative ( Figure ). Conclusions: In this sample, we observed elevated cardiac and inflammatory biomarkers indicative of myocardial injury. Further research on the durability of elevated cardiac biomarkers and their contributions to post-acute sequela of COVID-19 is needed.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/175668