Self-exothermic esterification-crosslinking of bio-polymer/graphene composite for application in interbody fusion cage

Ou, K; Liu, Q; Liu, X; Fu, Q; Fan, J; Sun, Y

Self-exothermic esterification-crosslinking of bio-polymer/graphene composite for application in interbody fusion cage

Ou, K Liu, Q Liu, X Fu, Q

Fan, J Sun, Y

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Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: MRS Communications, 2023, 13, (1), pp. 8-15
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Ou, K
dc.contributor.author	Liu, Q
dc.contributor.author	Liu, X
dc.contributor.author	Fu, Q https://orcid.org/0000-0002-4012-330X
dc.contributor.author	Fan, J
dc.contributor.author	Sun, Y
dc.date.accessioned	2024-02-20T23:42:11Z
dc.date.available	2024-02-20T23:42:11Z
dc.date.issued	2023
dc.identifier.citation	MRS Communications, 2023, 13, (1), pp. 8-15
dc.identifier.issn	2159-6859
dc.identifier.issn	2159-6867
dc.identifier.uri	http://hdl.handle.net/10453/175779
dc.description.abstract	The commercial interbody fusion cage is generally based on rigid materials (e.g. Ti metal, PEEK plastic and so on), resulting in discomfort and limiting the movement of vertebration for human. A new soft and elastic polymer composite is prepared by self-exothermic esterification-crosslinking method for application in interbody fusion cage. It is mainly composed of bio-polymer (e.g. PVA and Chitosan), hydroxyapatite and graphene nanosheets. The interbody fusion cage is fabricated by 3D printing and mould process from bio-polymer composite. The interbody fusion cage does not only show high elastic modulus (ca. 246.5 MPa), but also exhibits good compression elastic deformation (more than 15%), enhancing comfort of human. Furthermore, the interbody fusion cage can produce Ca ions and shows grade 1 (few reactivity) of cytotoxicity, indicating good osteoconductivity and biocompatibility. The work demonstrates the practical application of present bio-polymer/graphene composite in interbody fusion cage with comfort. Graphical Abstract: [Figure not available: see fulltext.]
dc.language	English
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	MRS Communications
dc.relation.isbasedon	10.1557/s43579-022-00296-0
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://dx.doi.org/10.1557/s43579-022-00296-0
dc.subject	0912 Materials Engineering
dc.subject.classification	4016 Materials engineering
dc.subject.classification	5104 Condensed matter physics
dc.title	Self-exothermic esterification-crosslinking of bio-polymer/graphene composite for application in interbody fusion cage
dc.type	Journal Article
utslib.citation.volume	13
utslib.for	0912 Materials Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2024-02-20T23:42:10Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	1

Abstract:

The commercial interbody fusion cage is generally based on rigid materials (e.g. Ti metal, PEEK plastic and so on), resulting in discomfort and limiting the movement of vertebration for human. A new soft and elastic polymer composite is prepared by self-exothermic esterification-crosslinking method for application in interbody fusion cage. It is mainly composed of bio-polymer (e.g. PVA and Chitosan), hydroxyapatite and graphene nanosheets. The interbody fusion cage is fabricated by 3D printing and mould process from bio-polymer composite. The interbody fusion cage does not only show high elastic modulus (ca. 246.5 MPa), but also exhibits good compression elastic deformation (more than 15%), enhancing comfort of human. Furthermore, the interbody fusion cage can produce Ca ions and shows grade 1 (few reactivity) of cytotoxicity, indicating good osteoconductivity and biocompatibility. The work demonstrates the practical application of present bio-polymer/graphene composite in interbody fusion cage with comfort. Graphical Abstract: [Figure not available: see fulltext.]

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http://hdl.handle.net/10453/175779