Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation.

Bashir, B; Alam, S; Khandale, N; Birla, D; Vishwas, S; Pandey, NK; Gupta, G; Paudel, KR; Dureja, H; Kumar, P; Singh, TG; Kuppusamy, G; Zacconi, F; Pinto, TDJA; Dhanasekaran, M; Gulati, M; Dua, K; Singh, SK

Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation.

Bashir, B Alam, S Khandale, N Birla, D Vishwas, S Pandey, NK Gupta, G Paudel, KR Dureja, H Kumar, P Singh, TG Kuppusamy, G Zacconi, F Pinto, TDJA Dhanasekaran, M Gulati, M Dua, K

Singh, SK

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Ageing Res Rev, 2024, pp. 102236
Issue Date:: 2024-02-16

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Field	Value	Language
dc.contributor.author	Bashir, B
dc.contributor.author	Alam, S
dc.contributor.author	Khandale, N
dc.contributor.author	Birla, D
dc.contributor.author	Vishwas, S
dc.contributor.author	Pandey, NK
dc.contributor.author	Gupta, G
dc.contributor.author	Paudel, KR
dc.contributor.author	Dureja, H
dc.contributor.author	Kumar, P
dc.contributor.author	Singh, TG
dc.contributor.author	Kuppusamy, G
dc.contributor.author	Zacconi, F
dc.contributor.author	Pinto, TDJA
dc.contributor.author	Dhanasekaran, M
dc.contributor.author	Gulati, M
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Singh, SK
dc.date.accessioned	2024-03-02T04:41:42Z
dc.date.available	2024-02-14
dc.date.available	2024-03-02T04:41:42Z
dc.date.issued	2024-02-16
dc.identifier.citation	Ageing Res Rev, 2024, pp. 102236
dc.identifier.issn	1568-1637
dc.identifier.issn	1872-9649
dc.identifier.uri	http://hdl.handle.net/10453/176016
dc.description.abstract	Recent studies have indicated the significant involvement of the gut microbiome in both human physiology and pathology. Additionally, therapeutic interventions based on microbiome approaches have been employed to enhance overall health and address various diseases including aging and neurodegenerative disease (ND). Researchers have explored potential links between these areas, investigating the potential pathogenic or therapeutic effects of intestinal microbiota in diseases. This article provides a summary of established interactions between the gut microbiome and ND. Post-biotic is believed to mediate its neuroprotection by elevating the level of dopamine and reducing the level of α-synuclein in substantia nigra, protecting the loss of dopaminergic neurons, reducing the aggregation of NFT, reducing the deposition of amyloid β peptide plagues and ameliorating motor deficits. Moreover, mediates its neuroprotective activity by inhibiting the inflammatory response (decreasing the expression of TNFα, iNOS expression, free radical formation, overexpression of HIF-1α), apoptosis (i.e. active caspase-3, TNF-α, maintains the level of Bax/Bcl-2 ratio) and promoting BDNF secretion. It is also reported to have good antioxidant activity. This review offers an overview of the latest findings from both preclinical and clinical trials concerning the use of post-biotics in ND.
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Ageing Res Rev
dc.relation.isbasedon	10.1016/j.arr.2024.102236
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	Gerontology
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3209 Neurosciences
dc.title	Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-02T04:41:38Z
pubs.publication-status	Published online

Abstract:

Recent studies have indicated the significant involvement of the gut microbiome in both human physiology and pathology. Additionally, therapeutic interventions based on microbiome approaches have been employed to enhance overall health and address various diseases including aging and neurodegenerative disease (ND). Researchers have explored potential links between these areas, investigating the potential pathogenic or therapeutic effects of intestinal microbiota in diseases. This article provides a summary of established interactions between the gut microbiome and ND. Post-biotic is believed to mediate its neuroprotection by elevating the level of dopamine and reducing the level of α-synuclein in substantia nigra, protecting the loss of dopaminergic neurons, reducing the aggregation of NFT, reducing the deposition of amyloid β peptide plagues and ameliorating motor deficits. Moreover, mediates its neuroprotective activity by inhibiting the inflammatory response (decreasing the expression of TNFα, iNOS expression, free radical formation, overexpression of HIF-1α), apoptosis (i.e. active caspase-3, TNF-α, maintains the level of Bax/Bcl-2 ratio) and promoting BDNF secretion. It is also reported to have good antioxidant activity. This review offers an overview of the latest findings from both preclinical and clinical trials concerning the use of post-biotics in ND.

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http://hdl.handle.net/10453/176016