Profile of different Hepatitis B virus integration frequency in hepatocellular carcinoma patients.
- Publisher:
- Elsevier
- Publication Type:
- Journal Article
- Citation:
- Biochem Biophys Res Commun, 2021, 553, pp. 160-164
- Issue Date:
- 2021-05-14
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Li, W | |
dc.contributor.author | Qi, Y | |
dc.contributor.author |
Xu, H https://orcid.org/0000-0003-1129-5337 |
|
dc.contributor.author | Wei, W | |
dc.contributor.author | Cui, X | |
dc.date.accessioned | 2024-03-12T03:58:05Z | |
dc.date.available | 2021-03-11 | |
dc.date.available | 2024-03-12T03:58:05Z | |
dc.date.issued | 2021-05-14 | |
dc.identifier.citation | Biochem Biophys Res Commun, 2021, 553, pp. 160-164 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.issn | 1090-2104 | |
dc.identifier.uri | http://hdl.handle.net/10453/176550 | |
dc.description.abstract | Hepatitis B virus (HBV) DNA integration is closely related to the occurrence of liver cancer. However, current studies mostly focus on the detection of the viral integration sites, ignoring the relationship between the frequency of viral integration and liver cancer. Thus, this study uses previous data to distinguish the breakpoints according to the integration frequency and analyzes the characteristics of different groups. This analysis revealed that three sets of breakpoints were characterized by its own integrated sample frequency, breakpoint distribution, and affected gene pathways. This result indicated an evolution in the virus integration sites in the process of tumor formation and development. Therefore, our research clarified the characteristics and differences in the sites of viral integration in tumors and adjacent tissues, and clarified the key signaling pathways affected by viral integration. Hence, these findings might be of great significance in the understanding of the role of viral integration frequency in hepatocellular carcinoma. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Biochem Biophys Res Commun | |
dc.relation.isbasedon | 10.1016/j.bbrc.2021.03.056 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0304 Medicinal and Biomolecular Chemistry, 0601 Biochemistry and Cell Biology, 1101 Medical Biochemistry and Metabolomics | |
dc.subject.classification | Biochemistry & Molecular Biology | |
dc.subject.classification | 3101 Biochemistry and cell biology | |
dc.subject.classification | 3404 Medicinal and biomolecular chemistry | |
dc.subject.mesh | Carcinogenesis | |
dc.subject.mesh | Carcinoma, Hepatocellular | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Chromosome Breakpoints | |
dc.subject.mesh | Gene Frequency | |
dc.subject.mesh | Hepatitis B virus | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Liver Neoplasms | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Virus Integration | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Hepatitis B virus | |
dc.subject.mesh | Carcinoma, Hepatocellular | |
dc.subject.mesh | Liver Neoplasms | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Virus Integration | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Gene Frequency | |
dc.subject.mesh | Chromosome Breakpoints | |
dc.subject.mesh | Carcinogenesis | |
dc.subject.mesh | Carcinogenesis | |
dc.subject.mesh | Carcinoma, Hepatocellular | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Chromosome Breakpoints | |
dc.subject.mesh | Gene Frequency | |
dc.subject.mesh | Hepatitis B virus | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Liver Neoplasms | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Virus Integration | |
dc.title | Profile of different Hepatitis B virus integration frequency in hepatocellular carcinoma patients. | |
dc.type | Journal Article | |
utslib.citation.volume | 553 | |
utslib.location.activity | United States | |
utslib.for | 0304 Medicinal and Biomolecular Chemistry | |
utslib.for | 0601 Biochemistry and Cell Biology | |
utslib.for | 1101 Medical Biochemistry and Metabolomics | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2024-03-12T03:58:04Z | |
pubs.publication-status | Published | |
pubs.volume | 553 |
Abstract:
Hepatitis B virus (HBV) DNA integration is closely related to the occurrence of liver cancer. However, current studies mostly focus on the detection of the viral integration sites, ignoring the relationship between the frequency of viral integration and liver cancer. Thus, this study uses previous data to distinguish the breakpoints according to the integration frequency and analyzes the characteristics of different groups. This analysis revealed that three sets of breakpoints were characterized by its own integrated sample frequency, breakpoint distribution, and affected gene pathways. This result indicated an evolution in the virus integration sites in the process of tumor formation and development. Therefore, our research clarified the characteristics and differences in the sites of viral integration in tumors and adjacent tissues, and clarified the key signaling pathways affected by viral integration. Hence, these findings might be of great significance in the understanding of the role of viral integration frequency in hepatocellular carcinoma.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph