Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.

Zhou, F; Cao, H; Zuo, X; Zhang, T; Zhang, X; Liu, X; Xu, R; Chen, G; Zhang, Y; Zheng, X; Jin, X; Gao, J; Mei, J; Sheng, Y; Li, Q; Liang, B; Shen, J; Shen, C; Jiang, H; Zhu, C; Fan, X; Xu, F; Yue, M; Yin, X; Ye, C; Zhang, C; Liu, X; Yu, L; Wu, J; Chen, M; Zhuang, X; Tang, L; Shao, H; Wu, L; Li, J; Xu, Y; Zhang, Y; Zhao, S; Wang, Y; Li, G; Xu, H; Zeng, L; Wang, J; Bai, M; Chen, Y; Chen, W; Kang, T; Wu, Y; Xu, X; Zhu, Z; Cui, Y; Wang, Z; Yang, C; Wang, P; Xiang, L; Chen, X; Zhang, A; Gao, X; Zhang, F; Xu, J; Zheng, M; Zheng, J; Zhang, J; Yu, X; Li, Y; Yang, S; Yang, H; Wang, J; Liu, J; Hammarström, L; Sun, L; Wang, J; Zhang, X

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.

Zhou, F Cao, H Zuo, X Zhang, T Zhang, X Liu, X Xu, R Chen, G Zhang, Y Zheng, X Jin, X Gao, J Mei, J Sheng, Y Li, Q Liang, B Shen, J Shen, C Jiang, H Zhu, C Fan, X Xu, F Yue, M Yin, X Ye, C Zhang, C Liu, X Yu, L Wu, J Chen, M Zhuang, X Tang, L Shao, H Wu, L Li, J Xu, Y Zhang, Y Zhao, S Wang, Y Li, G Xu, H

Zeng, L Wang, J Bai, M Chen, Y Chen, W Kang, T Wu, Y Xu, X Zhu, Z Cui, Y Wang, Z Yang, C Wang, P Xiang, L Chen, X Zhang, A Gao, X Zhang, F Xu, J Zheng, M Zheng, J Zhang, J Yu, X Li, Y Yang, S Yang, H Wang, J Liu, J Hammarström, L Sun, L Wang, J Zhang, X

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Nat Genet, 2016, 48, (7), pp. 740-746
Issue Date:: 2016-07

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Field	Value	Language
dc.contributor.author	Zhou, F
dc.contributor.author	Cao, H
dc.contributor.author	Zuo, X
dc.contributor.author	Zhang, T
dc.contributor.author	Zhang, X
dc.contributor.author	Liu, X
dc.contributor.author	Xu, R
dc.contributor.author	Chen, G
dc.contributor.author	Zhang, Y
dc.contributor.author	Zheng, X
dc.contributor.author	Jin, X
dc.contributor.author	Gao, J
dc.contributor.author	Mei, J
dc.contributor.author	Sheng, Y
dc.contributor.author	Li, Q
dc.contributor.author	Liang, B
dc.contributor.author	Shen, J
dc.contributor.author	Shen, C
dc.contributor.author	Jiang, H
dc.contributor.author	Zhu, C
dc.contributor.author	Fan, X
dc.contributor.author	Xu, F
dc.contributor.author	Yue, M
dc.contributor.author	Yin, X
dc.contributor.author	Ye, C
dc.contributor.author	Zhang, C
dc.contributor.author	Liu, X
dc.contributor.author	Yu, L
dc.contributor.author	Wu, J
dc.contributor.author	Chen, M
dc.contributor.author	Zhuang, X
dc.contributor.author	Tang, L
dc.contributor.author	Shao, H
dc.contributor.author	Wu, L
dc.contributor.author	Li, J
dc.contributor.author	Xu, Y
dc.contributor.author	Zhang, Y
dc.contributor.author	Zhao, S
dc.contributor.author	Wang, Y
dc.contributor.author	Li, G
dc.contributor.author	Xu, H https://orcid.org/0000-0003-1129-5337
dc.contributor.author	Zeng, L
dc.contributor.author	Wang, J
dc.contributor.author	Bai, M
dc.contributor.author	Chen, Y
dc.contributor.author	Chen, W
dc.contributor.author	Kang, T
dc.contributor.author	Wu, Y
dc.contributor.author	Xu, X
dc.contributor.author	Zhu, Z
dc.contributor.author	Cui, Y
dc.contributor.author	Wang, Z
dc.contributor.author	Yang, C
dc.contributor.author	Wang, P
dc.contributor.author	Xiang, L
dc.contributor.author	Chen, X
dc.contributor.author	Zhang, A
dc.contributor.author	Gao, X
dc.contributor.author	Zhang, F
dc.contributor.author	Xu, J
dc.contributor.author	Zheng, M
dc.contributor.author	Zheng, J
dc.contributor.author	Zhang, J
dc.contributor.author	Yu, X
dc.contributor.author	Li, Y
dc.contributor.author	Yang, S
dc.contributor.author	Yang, H
dc.contributor.author	Wang, J
dc.contributor.author	Liu, J
dc.contributor.author	Hammarström, L
dc.contributor.author	Sun, L
dc.contributor.author	Wang, J
dc.contributor.author	Zhang, X
dc.date.accessioned	2024-03-12T04:03:50Z
dc.date.available	2016-04-29
dc.date.available	2024-03-12T04:03:50Z
dc.date.issued	2016-07
dc.identifier.citation	Nat Genet, 2016, 48, (7), pp. 740-746
dc.identifier.issn	1061-4036
dc.identifier.issn	1546-1718
dc.identifier.uri	http://hdl.handle.net/10453/176555
dc.description.abstract	The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy. We further identified multiple independent new susceptibility loci in HLA-C, HLA-B, HLA-DPB1 and BTNL2 and an intergenic variant, rs118179173, associated with psoriasis and confirmed the well-established risk allele HLA-C*06:02. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance understanding of the pathogenesis of these disorders.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Nat Genet
dc.relation.isbasedon	10.1038/ng.3576
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Developmental Biology
dc.subject.classification	3001 Agricultural biotechnology
dc.subject.classification	3102 Bioinformatics and computational biology
dc.subject.classification	3105 Genetics
dc.subject.mesh	Asian People
dc.subject.mesh	Butyrophilins
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	China
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	HLA-B Antigens
dc.subject.mesh	HLA-C Antigens
dc.subject.mesh	HLA-DP beta-Chains
dc.subject.mesh	High-Throughput Nucleotide Sequencing
dc.subject.mesh	Humans
dc.subject.mesh	Major Histocompatibility Complex
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Psoriasis
dc.subject.mesh	Humans
dc.subject.mesh	Psoriasis
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	HLA-B Antigens
dc.subject.mesh	HLA-C Antigens
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Major Histocompatibility Complex
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	China
dc.subject.mesh	High-Throughput Nucleotide Sequencing
dc.subject.mesh	HLA-DP beta-Chains
dc.subject.mesh	Butyrophilins
dc.subject.mesh	Asian People
dc.subject.mesh	Asian People
dc.subject.mesh	Butyrophilins
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	China
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	HLA-B Antigens
dc.subject.mesh	HLA-C Antigens
dc.subject.mesh	HLA-DP beta-Chains
dc.subject.mesh	High-Throughput Nucleotide Sequencing
dc.subject.mesh	Humans
dc.subject.mesh	Major Histocompatibility Complex
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Psoriasis
dc.title	Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.
dc.type	Journal Article
utslib.citation.volume	48
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-12T04:03:49Z
pubs.issue	7
pubs.publication-status	Published
pubs.volume	48
utslib.citation.issue	7

Abstract:

The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy. We further identified multiple independent new susceptibility loci in HLA-C, HLA-B, HLA-DPB1 and BTNL2 and an intergenic variant, rs118179173, associated with psoriasis and confirmed the well-established risk allele HLA-C*06:02. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance understanding of the pathogenesis of these disorders.

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http://hdl.handle.net/10453/176555