Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19.

Khoo, WH; Jackson, K; Phetsouphanh, C; Zaunders, JJ; Alquicira-Hernandez, J; Yazar, S; Ruiz-Diaz, S; Singh, M; Dhenni, R; Kyaw, W; Tea, F; Merheb, V; Lee, FXZ; Burrell, R; Howard-Jones, A; Koirala, A; Zhou, L; Yuksel, A; Catchpoole, DR; Lai, CL; Vitagliano, TL; Rouet, R; Christ, D; Tang, B; West, NP; George, S; Gerrard, J; Croucher, PI; Kelleher, AD; Goodnow, CG; Sprent, JD; Powell, JE; Brilot, F; Nanan, R; Hsu, PS; Deenick, EK; Britton, PN; Phan, TG

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19.

Khoo, WH Jackson, K Phetsouphanh, C Zaunders, JJ Alquicira-Hernandez, J Yazar, S Ruiz-Diaz, S Singh, M Dhenni, R Kyaw, W Tea, F Merheb, V Lee, FXZ Burrell, R Howard-Jones, A Koirala, A Zhou, L Yuksel, A Catchpoole, DR Lai, CL Vitagliano, TL Rouet, R Christ, D Tang, B West, NP George, S Gerrard, J Croucher, PI Kelleher, AD Goodnow, CG Sprent, JD Powell, JE Brilot, F Nanan, R Hsu, PS Deenick, EK Britton, PN Phan, TG

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Publisher:: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Type:: Journal Article
Citation:: Clin Immunol, 2023, 246, pp. 109209
Issue Date:: 2023-01

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Field	Value	Language
dc.contributor.author	Khoo, WH
dc.contributor.author	Jackson, K
dc.contributor.author	Phetsouphanh, C
dc.contributor.author	Zaunders, JJ
dc.contributor.author	Alquicira-Hernandez, J
dc.contributor.author	Yazar, S
dc.contributor.author	Ruiz-Diaz, S
dc.contributor.author	Singh, M
dc.contributor.author	Dhenni, R
dc.contributor.author	Kyaw, W
dc.contributor.author	Tea, F
dc.contributor.author	Merheb, V
dc.contributor.author	Lee, FXZ
dc.contributor.author	Burrell, R
dc.contributor.author	Howard-Jones, A
dc.contributor.author	Koirala, A
dc.contributor.author	Zhou, L
dc.contributor.author	Yuksel, A
dc.contributor.author	Catchpoole, DR
dc.contributor.author	Lai, CL
dc.contributor.author	Vitagliano, TL
dc.contributor.author	Rouet, R
dc.contributor.author	Christ, D
dc.contributor.author	Tang, B
dc.contributor.author	West, NP
dc.contributor.author	George, S
dc.contributor.author	Gerrard, J
dc.contributor.author	Croucher, PI
dc.contributor.author	Kelleher, AD
dc.contributor.author	Goodnow, CG
dc.contributor.author	Sprent, JD
dc.contributor.author	Powell, JE
dc.contributor.author	Brilot, F
dc.contributor.author	Nanan, R
dc.contributor.author	Hsu, PS
dc.contributor.author	Deenick, EK
dc.contributor.author	Britton, PN
dc.contributor.author	Phan, TG
dc.date.accessioned	2024-03-14T04:37:04Z
dc.date.available	2022-12-11
dc.date.available	2024-03-14T04:37:04Z
dc.date.issued	2023-01
dc.identifier.citation	Clin Immunol, 2023, 246, pp. 109209
dc.identifier.issn	1521-6616
dc.identifier.issn	1521-7035
dc.identifier.uri	http://hdl.handle.net/10453/176706
dc.description.abstract	Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced immunity are beginning to be uncovered. We show by longitudinal multimodal analysis that SARS-CoV-2 leaves a small footprint in the circulating T cell compartment in children with mild/asymptomatic COVID-19 compared to adult household contacts with the same disease severity who had more evidence of systemic T cell interferon activation, cytotoxicity and exhaustion. Children harbored diverse polyclonal SARS-CoV-2-specific naïve T cells whereas adults harbored clonally expanded SARS-CoV-2-specific memory T cells. A novel population of naïve interferon-activated T cells is expanded in acute COVID-19 and is recruited into the memory compartment during convalescence in adults but not children. This was associated with the development of robust CD4+ memory T cell responses in adults but not children. These data suggest that rapid clearance of SARS-CoV-2 in children may compromise their cellular immunity and ability to resist reinfection.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartof	Clin Immunol
dc.relation.isbasedon	10.1016/j.clim.2022.109209
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1107 Immunology
dc.subject.classification	Immunology
dc.subject.classification	3204 Immunology
dc.subject.mesh	Humans
dc.subject.mesh	Adult
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	CD4-Positive T-Lymphocytes
dc.subject.mesh	Immunity, Cellular
dc.subject.mesh	Lymphocyte Activation
dc.subject.mesh	Antibodies, Viral
dc.subject.mesh	CD4-Positive T-Lymphocytes
dc.subject.mesh	Humans
dc.subject.mesh	Antibodies, Viral
dc.subject.mesh	Lymphocyte Activation
dc.subject.mesh	Immunity, Cellular
dc.subject.mesh	Adult
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Humans
dc.subject.mesh	Adult
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	CD4-Positive T-Lymphocytes
dc.subject.mesh	Immunity, Cellular
dc.subject.mesh	Lymphocyte Activation
dc.subject.mesh	Antibodies, Viral
dc.title	Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19.
dc.type	Journal Article
utslib.citation.volume	246
utslib.location.activity	United States
utslib.for	1107 Immunology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
utslib.copyright.status	open_access	*
dc.date.updated	2024-03-14T04:36:55Z
pubs.publication-status	Published
pubs.volume	246

Abstract:

Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced immunity are beginning to be uncovered. We show by longitudinal multimodal analysis that SARS-CoV-2 leaves a small footprint in the circulating T cell compartment in children with mild/asymptomatic COVID-19 compared to adult household contacts with the same disease severity who had more evidence of systemic T cell interferon activation, cytotoxicity and exhaustion. Children harbored diverse polyclonal SARS-CoV-2-specific naïve T cells whereas adults harbored clonally expanded SARS-CoV-2-specific memory T cells. A novel population of naïve interferon-activated T cells is expanded in acute COVID-19 and is recruited into the memory compartment during convalescence in adults but not children. This was associated with the development of robust CD4+ memory T cell responses in adults but not children. These data suggest that rapid clearance of SARS-CoV-2 in children may compromise their cellular immunity and ability to resist reinfection.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/176706