Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study.

Li, Y; Liang, X; Lyu, Y; Wang, K; Han, L; Wang, Y; Sun, J; Chi, C

Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study.

Li, Y Liang, X Lyu, Y Wang, K Han, L Wang, Y Sun, J

Chi, C

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Publisher:: ELSEVIER SCIENCE INC
Publication Type:: Journal Article
Citation:: Dig Liver Dis, 2023, 55, (11), pp. 1464-1471
Issue Date:: 2023-11

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Field	Value	Language
dc.contributor.author	Li, Y
dc.contributor.author	Liang, X
dc.contributor.author	Lyu, Y
dc.contributor.author	Wang, K
dc.contributor.author	Han, L
dc.contributor.author	Wang, Y
dc.contributor.author	Sun, J https://orcid.org/0000-0002-0097-2438
dc.contributor.author	Chi, C
dc.date.accessioned	2024-03-27T04:12:45Z
dc.date.available	2023-07-11
dc.date.available	2024-03-27T04:12:45Z
dc.date.issued	2023-11
dc.identifier.citation	Dig Liver Dis, 2023, 55, (11), pp. 1464-1471
dc.identifier.issn	1590-8658
dc.identifier.issn	1878-3562
dc.identifier.uri	http://hdl.handle.net/10453/177254
dc.description.abstract	BACKGROUND: Increasing studies have shown that there is a significant association between gut microbiota and non-alcoholic fatty liver disease. AIMS: To show the potential association between gut microbiota and non-alcoholic fatty liver disease, we performed a two-sample Mendelian randomization analysis. METHODS: We analyzed summary statistics from genome-wide association studies of gut microbiota and non-alcoholic fatty liver disease and conducted Mendelian randomization studies to evaluate relationships between these factors. RESULTS: Of the 211 gut microbiota taxa examined, the inverse variance weighted method identified Lactobacillaceae (OR = 0.83, 95% CI = 0.72 - 0.95, P = 0.007), Christensenellaceae (OR = 0.74, 95% CI = 0.59 - 0.92, P = 0.007), and Intestinibacter (OR = 0.85, 95% CI = 0.73 - 0.99, P = 0.035) were negatively correlated with non-alcoholic fatty liver disease. And Coriobacteriia (OR = 1.22, 95% CI = 1.01 - 1.42, P = 0.038), Actinomycetales (OR = 1.25, 95% CI = 1.02 - 1.53, P = 0.031), Oxalobacteraceae (OR = 1.10, 95% CI = 1.01 - 1.21, P = 0.036), Ruminococcaceae_UCG005 (OR = 1.18, 95% CI = 1.01 - 1.38, P = 0.033) are positively associated with non-alcoholic fatty liver disease. CONCLUSIONS: Our study found that the abundance of certain strains was associated with the progression of nonalcoholic fatty liver disease.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE INC
dc.relation.ispartof	Dig Liver Dis
dc.relation.isbasedon	10.1016/j.dld.2023.07.014
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences
dc.subject.classification	Gastroenterology & Hepatology
dc.subject.classification	3202 Clinical sciences
dc.subject.mesh	Humans
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	Genome-Wide Association Study
dc.subject.mesh	Mendelian Randomization Analysis
dc.subject.mesh	Non-alcoholic Fatty Liver Disease
dc.subject.mesh	Actinobacteria
dc.subject.mesh	Humans
dc.subject.mesh	Actinobacteria
dc.subject.mesh	Genome-Wide Association Study
dc.subject.mesh	Mendelian Randomization Analysis
dc.subject.mesh	Non-alcoholic Fatty Liver Disease
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	Humans
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	Genome-Wide Association Study
dc.subject.mesh	Mendelian Randomization Analysis
dc.subject.mesh	Non-alcoholic Fatty Liver Disease
dc.subject.mesh	Actinobacteria
dc.title	Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study.
dc.type	Journal Article
utslib.citation.volume	55
utslib.location.activity	Netherlands
utslib.for	1103 Clinical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-27T04:12:44Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	55
utslib.citation.issue	11

Abstract:

BACKGROUND: Increasing studies have shown that there is a significant association between gut microbiota and non-alcoholic fatty liver disease. AIMS: To show the potential association between gut microbiota and non-alcoholic fatty liver disease, we performed a two-sample Mendelian randomization analysis. METHODS: We analyzed summary statistics from genome-wide association studies of gut microbiota and non-alcoholic fatty liver disease and conducted Mendelian randomization studies to evaluate relationships between these factors. RESULTS: Of the 211 gut microbiota taxa examined, the inverse variance weighted method identified Lactobacillaceae (OR = 0.83, 95% CI = 0.72 - 0.95, P = 0.007), Christensenellaceae (OR = 0.74, 95% CI = 0.59 - 0.92, P = 0.007), and Intestinibacter (OR = 0.85, 95% CI = 0.73 - 0.99, P = 0.035) were negatively correlated with non-alcoholic fatty liver disease. And Coriobacteriia (OR = 1.22, 95% CI = 1.01 - 1.42, P = 0.038), Actinomycetales (OR = 1.25, 95% CI = 1.02 - 1.53, P = 0.031), Oxalobacteraceae (OR = 1.10, 95% CI = 1.01 - 1.21, P = 0.036), Ruminococcaceae_UCG005 (OR = 1.18, 95% CI = 1.01 - 1.38, P = 0.033) are positively associated with non-alcoholic fatty liver disease. CONCLUSIONS: Our study found that the abundance of certain strains was associated with the progression of nonalcoholic fatty liver disease.

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http://hdl.handle.net/10453/177254