Spike and wave discharges detection in genetic absence epilepsy rat from Strasbourg and patients with genetic generalized epilepsy.

Li, R; Millist, L; Foster, E; Yuan, X; Guvenc, U; Radfar, M; Marendy, P; Ni, W; O'Brien, TJ; Casillas-Espinosa, PM

Spike and wave discharges detection in genetic absence epilepsy rat from Strasbourg and patients with genetic generalized epilepsy.

Li, R Millist, L Foster, E Yuan, X

Guvenc, U Radfar, M Marendy, P Ni, W

O'Brien, TJ Casillas-Espinosa, PM

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Epilepsy Res, 2023, 194, pp. 107181
Issue Date:: 2023-08

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Field	Value	Language
dc.contributor.author	Li, R
dc.contributor.author	Millist, L
dc.contributor.author	Foster, E
dc.contributor.author	Yuan, X https://orcid.org/0000-0002-9167-1613
dc.contributor.author	Guvenc, U
dc.contributor.author	Radfar, M
dc.contributor.author	Marendy, P
dc.contributor.author	Ni, W https://orcid.org/0000-0002-4933-594X
dc.contributor.author	O'Brien, TJ
dc.contributor.author	Casillas-Espinosa, PM
dc.date.accessioned	2024-04-17T02:03:48Z
dc.date.available	2023-06-13
dc.date.available	2024-04-17T02:03:48Z
dc.date.issued	2023-08
dc.identifier.citation	Epilepsy Res, 2023, 194, pp. 107181
dc.identifier.issn	0920-1211
dc.identifier.issn	1872-6844
dc.identifier.uri	http://hdl.handle.net/10453/177998
dc.description.abstract	OBJECTIVE: Generalised spike and wave discharges (SWDs) are pathognomonic EEG signatures for diagnosing absence seizures in patients with Genetic Generalized Epilepsy (GGE). The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is one of the best-validated animal models of GGE with absence seizures. METHODS: We developed an SWDs detector for both GAERS rodents and GGE patients with absence seizures using a neural network method. We included 192 24-hour EEG sessions recorded from 18 GAERS rats, and 24-hour scalp-EEG data collected from 11 GGE patients. RESULTS: The SWDs detection performance on GAERS showed a sensitivity of 98.01% and a false positive (FP) rate of 0.96/hour. The performance on GGE patients showed 100% sensitivity in five patients, while the remaining patients obtained over 98.9% sensitivity. Moderate FP rates were seen in our patients with 2.21/hour average FP. The detector trained within our patient cohort was validated in an independent dataset, TUH EEG Seizure Corpus (TUSZ), that showed 100% sensitivity in 11 of 12 patients and 0.56/hour averaged FP. CONCLUSIONS: We developed a robust SWDs detector that showed high sensitivity and specificity for both GAERS rats and GGE patients. SIGNIFICANCE: This detector can assist researchers and neurologists with the time-efficient and accurate quantification of SWDs.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER
dc.relation.ispartof	Epilepsy Res
dc.relation.isbasedon	10.1016/j.eplepsyres.2023.107181
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.classification	3209 Neurosciences
dc.subject.classification	5202 Biological psychology
dc.subject.classification	5203 Clinical and health psychology
dc.subject.mesh	Rats
dc.subject.mesh	Animals
dc.subject.mesh	Epilepsy, Absence
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Epilepsy, Generalized
dc.subject.mesh	Seizures
dc.subject.mesh	Electroencephalography
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Epilepsy, Generalized
dc.subject.mesh	Epilepsy, Absence
dc.subject.mesh	Seizures
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Electroencephalography
dc.subject.mesh	Rats
dc.subject.mesh	Animals
dc.subject.mesh	Epilepsy, Absence
dc.subject.mesh	Rats, Wistar
dc.subject.mesh	Epilepsy, Generalized
dc.subject.mesh	Seizures
dc.subject.mesh	Electroencephalography
dc.subject.mesh	Disease Models, Animal
dc.title	Spike and wave discharges detection in genetic absence epilepsy rat from Strasbourg and patients with genetic generalized epilepsy.
dc.type	Journal Article
utslib.citation.volume	194
utslib.location.activity	Netherlands
utslib.for	1103 Clinical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-17T02:03:47Z
pubs.publication-status	Published
pubs.volume	194

Abstract:

OBJECTIVE: Generalised spike and wave discharges (SWDs) are pathognomonic EEG signatures for diagnosing absence seizures in patients with Genetic Generalized Epilepsy (GGE). The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is one of the best-validated animal models of GGE with absence seizures. METHODS: We developed an SWDs detector for both GAERS rodents and GGE patients with absence seizures using a neural network method. We included 192 24-hour EEG sessions recorded from 18 GAERS rats, and 24-hour scalp-EEG data collected from 11 GGE patients. RESULTS: The SWDs detection performance on GAERS showed a sensitivity of 98.01% and a false positive (FP) rate of 0.96/hour. The performance on GGE patients showed 100% sensitivity in five patients, while the remaining patients obtained over 98.9% sensitivity. Moderate FP rates were seen in our patients with 2.21/hour average FP. The detector trained within our patient cohort was validated in an independent dataset, TUH EEG Seizure Corpus (TUSZ), that showed 100% sensitivity in 11 of 12 patients and 0.56/hour averaged FP. CONCLUSIONS: We developed a robust SWDs detector that showed high sensitivity and specificity for both GAERS rats and GGE patients. SIGNIFICANCE: This detector can assist researchers and neurologists with the time-efficient and accurate quantification of SWDs.

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http://hdl.handle.net/10453/177998