Evaluation of colonic anastomosis healing using hybrid nanosheets containing molybdenum disulfide (MOS2) scaffold of human placental amniotic membrane and polycaprolactone (PCL) in rat animal model.

Ebrahim Soltani, Z; Elahi, M; Tashak-Golroudbari, H; Nazari, H; Badripour, A; Heirani-Tabasi, A; Akbari Asbagh, R; Dabbagh Ohadi, MA; Shabani, M; Sarzaeim, M; Behboudi, B; Keramati, MR; Kazemeini, A; Ahmadi Tafti, SM

Evaluation of colonic anastomosis healing using hybrid nanosheets containing molybdenum disulfide (MOS2) scaffold of human placental amniotic membrane and polycaprolactone (PCL) in rat animal model.

Ebrahim Soltani, Z Elahi, M Tashak-Golroudbari, H Nazari, H Badripour, A Heirani-Tabasi, A Akbari Asbagh, R Dabbagh Ohadi, MA Shabani, M Sarzaeim, M Behboudi, B Keramati, MR Kazemeini, A Ahmadi Tafti, SM

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Naunyn Schmiedebergs Arch Pharmacol, 2023, 396, (9), pp. 1911-1921
Issue Date:: 2023-09

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Field	Value	Language
dc.contributor.author	Ebrahim Soltani, Z
dc.contributor.author	Elahi, M
dc.contributor.author	Tashak-Golroudbari, H
dc.contributor.author	Nazari, H
dc.contributor.author	Badripour, A
dc.contributor.author	Heirani-Tabasi, A
dc.contributor.author	Akbari Asbagh, R
dc.contributor.author	Dabbagh Ohadi, MA
dc.contributor.author	Shabani, M
dc.contributor.author	Sarzaeim, M
dc.contributor.author	Behboudi, B
dc.contributor.author	Keramati, MR
dc.contributor.author	Kazemeini, A
dc.contributor.author	Ahmadi Tafti, SM
dc.date.accessioned	2024-04-26T02:21:18Z
dc.date.available	2023-02-20
dc.date.available	2024-04-26T02:21:18Z
dc.date.issued	2023-09
dc.identifier.citation	Naunyn Schmiedebergs Arch Pharmacol, 2023, 396, (9), pp. 1911-1921
dc.identifier.issn	0028-1298
dc.identifier.issn	1432-1912
dc.identifier.uri	http://hdl.handle.net/10453/178385
dc.description.abstract	Anastomosis is a standard technique following different conditions such as obstruction, tumor, and trauma. Obstruction, adhesion, or anastomosis leakage can be some of its complications. To improve healing and prevent postoperative complications, we design a hybrid scaffold containing acellular human amniotic membranes and polycaprolactone-molybdenum disulfide nanosheets for colon anastomosis. The animal model of colocolonic anastomosis was performed on two groups of rats: control and scaffold. The hybrid scaffold was warped around the anastomosis site in the scaffold group. Samples from the anastomosis site were resected on the third and seventh postoperative days for histopathological and molecular assessments. Histopathologic score and burst pressure had shown significant improvement in the scaffold group. No mortality and anastomosis leakage was reported in the scaffold group. In addition, inflammatory markers were significantly decreased, while anti-inflammatory cytokines were increased in the scaffold group. The result indicates that our hybrid scaffold is a proper choice for colorectal anastomosis repair by declining postoperative complications and accelerating healing.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Naunyn Schmiedebergs Arch Pharmacol
dc.relation.isbasedon	10.1007/s00210-023-02438-0
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences, 1116 Medical Physiology
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.mesh	Humans
dc.subject.mesh	Pregnancy
dc.subject.mesh	Rats
dc.subject.mesh	Female
dc.subject.mesh	Animals
dc.subject.mesh	Colon
dc.subject.mesh	Molybdenum
dc.subject.mesh	Amnion
dc.subject.mesh	Wound Healing
dc.subject.mesh	Placenta
dc.subject.mesh	Postoperative Complications
dc.subject.mesh	Anastomosis, Surgical
dc.subject.mesh	Models, Animal
dc.subject.mesh	Colon
dc.subject.mesh	Amnion
dc.subject.mesh	Placenta
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Rats
dc.subject.mesh	Postoperative Complications
dc.subject.mesh	Molybdenum
dc.subject.mesh	Anastomosis, Surgical
dc.subject.mesh	Models, Animal
dc.subject.mesh	Wound Healing
dc.subject.mesh	Pregnancy
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Pregnancy
dc.subject.mesh	Rats
dc.subject.mesh	Female
dc.subject.mesh	Animals
dc.subject.mesh	Colon
dc.subject.mesh	Molybdenum
dc.subject.mesh	Amnion
dc.subject.mesh	Wound Healing
dc.subject.mesh	Placenta
dc.subject.mesh	Postoperative Complications
dc.subject.mesh	Anastomosis, Surgical
dc.subject.mesh	Models, Animal
dc.title	Evaluation of colonic anastomosis healing using hybrid nanosheets containing molybdenum disulfide (MOS2) scaffold of human placental amniotic membrane and polycaprolactone (PCL) in rat animal model.
dc.type	Journal Article
utslib.citation.volume	396
utslib.location.activity	Germany
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1116 Medical Physiology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-26T02:21:16Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	396
utslib.citation.issue	9

Abstract:

Anastomosis is a standard technique following different conditions such as obstruction, tumor, and trauma. Obstruction, adhesion, or anastomosis leakage can be some of its complications. To improve healing and prevent postoperative complications, we design a hybrid scaffold containing acellular human amniotic membranes and polycaprolactone-molybdenum disulfide nanosheets for colon anastomosis. The animal model of colocolonic anastomosis was performed on two groups of rats: control and scaffold. The hybrid scaffold was warped around the anastomosis site in the scaffold group. Samples from the anastomosis site were resected on the third and seventh postoperative days for histopathological and molecular assessments. Histopathologic score and burst pressure had shown significant improvement in the scaffold group. No mortality and anastomosis leakage was reported in the scaffold group. In addition, inflammatory markers were significantly decreased, while anti-inflammatory cytokines were increased in the scaffold group. The result indicates that our hybrid scaffold is a proper choice for colorectal anastomosis repair by declining postoperative complications and accelerating healing.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/178385