Natural deep eutectic solvents for Ultrasonic-Assisted extraction of nutritious date Sugar: Molecular Screening, Experimental, and prediction.

AlYammahi, J; Darwish, AS; Almustafa, G; Lemaoui, T; AlNashef, IM; Hasan, SW; Taher, H; Banat, F

Natural deep eutectic solvents for Ultrasonic-Assisted extraction of nutritious date Sugar: Molecular Screening, Experimental, and prediction.

AlYammahi, J Darwish, AS Almustafa, G

Lemaoui, T AlNashef, IM Hasan, SW Taher, H Banat, F

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Ultrason Sonochem, 2023, 98, pp. 106514
Issue Date:: 2023-08

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Field	Value	Language
dc.contributor.author	AlYammahi, J
dc.contributor.author	Darwish, AS
dc.contributor.author	Almustafa, G https://orcid.org/0000-0003-1251-9945
dc.contributor.author	Lemaoui, T
dc.contributor.author	AlNashef, IM
dc.contributor.author	Hasan, SW
dc.contributor.author	Taher, H
dc.contributor.author	Banat, F
dc.date.accessioned	2024-04-26T04:54:35Z
dc.date.available	2023-07-03
dc.date.available	2024-04-26T04:54:35Z
dc.date.issued	2023-08
dc.identifier.citation	Ultrason Sonochem, 2023, 98, pp. 106514
dc.identifier.issn	1350-4177
dc.identifier.issn	1873-2828
dc.identifier.uri	http://hdl.handle.net/10453/178395
dc.description.abstract	The aim of this study is to develop an environmentally friendly and effective method for the extraction of nutritious date sugar using natural deep eutectic solvents (NADES) and ultrasound-assisted extraction (USAE). The careful design of a suitable NADES-USAE system was systematically supported by COSMO-RS screening, response surface method (RSM) and artificial neural network (ANN). Initially, 26 natural hydrogen bond donors (HBDs) were carefully screened for sugar affinity using COSMO-RS. The best performing HBDs were then used for the synthesis of 5 NADES using choline chloride (ChCl) as HBA. Among the synthesized NADES, the mixture of ChCl, citric acid (CA) and water (1:1:1 with 20 wt% water) resulted in the highest sugar yield of 78.30 ± 3.91 g/100 g, which is superior to conventional solvents such as water (29.92 ± 1.50 g/100 g). Further enhancements using RSM and ANN led to an even higher sugar recovery of 87.81 ± 2.61 g/100 g, at conditions of 30 °C, 45 min, and a solvent to DFP ratio of 40 mL/g. The method NADES-USAE was then compared with conventional hot water extraction (CHWE) (61.36 ± 3.06) and showed 43.1% higher sugar yield. The developed process not only improves the recovery of the nutritious date sugar but also preserves the heat-sensitive bioactive compounds in dates, making it an attractive alternative to CHWE for industrial utilization. Overall, this study shows a promising approach for the extraction of nutritive sugars from dates using environmentally friendly solvents and advanced technology. It also highlights the potential of this approach for valorizing underutilized fruits and preserving their bioactive compounds.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER
dc.relation.ispartof	Ultrason Sonochem
dc.relation.isbasedon	10.1016/j.ultsonch.2023.106514
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0306 Physical Chemistry (incl. Structural), 0913 Mechanical Engineering
dc.subject.classification	Organic Chemistry
dc.subject.classification	3406 Physical chemistry
dc.subject.classification	4004 Chemical engineering
dc.subject.mesh	Deep Eutectic Solvents
dc.subject.mesh	Sugars
dc.subject.mesh	Ultrasonics
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Solvents
dc.subject.mesh	Water
dc.subject.mesh	Choline
dc.subject.mesh	Water
dc.subject.mesh	Choline
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Solvents
dc.subject.mesh	Ultrasonics
dc.subject.mesh	Sugars
dc.subject.mesh	Deep Eutectic Solvents
dc.subject.mesh	Deep Eutectic Solvents
dc.subject.mesh	Sugars
dc.subject.mesh	Ultrasonics
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Solvents
dc.subject.mesh	Water
dc.subject.mesh	Choline
dc.title	Natural deep eutectic solvents for Ultrasonic-Assisted extraction of nutritious date Sugar: Molecular Screening, Experimental, and prediction.
dc.type	Journal Article
utslib.citation.volume	98
utslib.location.activity	Netherlands
utslib.for	0306 Physical Chemistry (incl. Structural)
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-26T04:54:25Z
pubs.publication-status	Published
pubs.volume	98

Abstract:

The aim of this study is to develop an environmentally friendly and effective method for the extraction of nutritious date sugar using natural deep eutectic solvents (NADES) and ultrasound-assisted extraction (USAE). The careful design of a suitable NADES-USAE system was systematically supported by COSMO-RS screening, response surface method (RSM) and artificial neural network (ANN). Initially, 26 natural hydrogen bond donors (HBDs) were carefully screened for sugar affinity using COSMO-RS. The best performing HBDs were then used for the synthesis of 5 NADES using choline chloride (ChCl) as HBA. Among the synthesized NADES, the mixture of ChCl, citric acid (CA) and water (1:1:1 with 20 wt% water) resulted in the highest sugar yield of 78.30 ± 3.91 g/100 g, which is superior to conventional solvents such as water (29.92 ± 1.50 g/100 g). Further enhancements using RSM and ANN led to an even higher sugar recovery of 87.81 ± 2.61 g/100 g, at conditions of 30 °C, 45 min, and a solvent to DFP ratio of 40 mL/g. The method NADES-USAE was then compared with conventional hot water extraction (CHWE) (61.36 ± 3.06) and showed 43.1% higher sugar yield. The developed process not only improves the recovery of the nutritious date sugar but also preserves the heat-sensitive bioactive compounds in dates, making it an attractive alternative to CHWE for industrial utilization. Overall, this study shows a promising approach for the extraction of nutritive sugars from dates using environmentally friendly solvents and advanced technology. It also highlights the potential of this approach for valorizing underutilized fruits and preserving their bioactive compounds.

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http://hdl.handle.net/10453/178395