Understanding the Therapeutic Approaches for Neuroprotection.

Payal, N; Sharma, L; Sharma, A; Hobanii, YH; Hakami, MA; Ali, N; Rashid, S; Sachdeva, M; Gulati, M; Yadav, S; Chigurupati, S; Singh, A; Khan, H; Behl, T

Understanding the Therapeutic Approaches for Neuroprotection.

Payal, N Sharma, L Sharma, A Hobanii, YH Hakami, MA Ali, N Rashid, S Sachdeva, M Gulati, M Yadav, S Chigurupati, S Singh, A Khan, H Behl, T

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Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Curr Pharm Des, 2023, 29, (42), pp. 3368-3384
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Payal, N
dc.contributor.author	Sharma, L
dc.contributor.author	Sharma, A
dc.contributor.author	Hobanii, YH
dc.contributor.author	Hakami, MA
dc.contributor.author	Ali, N
dc.contributor.author	Rashid, S
dc.contributor.author	Sachdeva, M
dc.contributor.author	Gulati, M
dc.contributor.author	Yadav, S
dc.contributor.author	Chigurupati, S
dc.contributor.author	Singh, A
dc.contributor.author	Khan, H
dc.contributor.author	Behl, T
dc.date.accessioned	2024-05-30T22:40:16Z
dc.date.available	2023-10-07
dc.date.available	2024-05-30T22:40:16Z
dc.date.issued	2023
dc.identifier.citation	Curr Pharm Des, 2023, 29, (42), pp. 3368-3384
dc.identifier.issn	1381-6128
dc.identifier.issn	1873-4286
dc.identifier.uri	http://hdl.handle.net/10453/179360
dc.description.abstract	The term "neurodegenerative disorders" refers to a group of illnesses in which deterioration of nerve structure and function is a prominent feature. Cognitive capacities such as memory and decision-making deteriorate as a result of neuronal damage. The primary difficulty that remains is safeguarding neurons since they do not proliferate or regenerate spontaneously and are therefore not substituted by the body after they have been damaged. Millions of individuals throughout the world suffer from neurodegenerative diseases. Various pathways lead to neurodegeneration, including endoplasmic reticulum stress, calcium ion overload, mitochondrial dysfunction, reactive oxygen species generation, and apoptosis. Although different treatments and therapies are available for neuroprotection after a brain injury or damage, the obstacles are inextricably connected. Several studies have revealed the pathogenic effects of hypothermia, different breathed gases, stem cell treatments, mitochondrial transplantation, multi-pharmacological therapy, and other therapies that have improved neurological recovery and survival outcomes after brain damage. The present review highlights the use of therapeutic approaches that can be targeted to develop and understand significant therapies for treating neurodegenerative diseases.
dc.format	Print
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation.ispartof	Curr Pharm Des
dc.relation.isbasedon	10.2174/0113816128275761231103102125
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.mesh	Humans
dc.subject.mesh	Neuroprotection
dc.subject.mesh	Mitochondria
dc.subject.mesh	Neurons
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Endoplasmic Reticulum Stress
dc.subject.mesh	Brain Injuries
dc.subject.mesh	Oxidative Stress
dc.subject.mesh	Neurons
dc.subject.mesh	Mitochondria
dc.subject.mesh	Humans
dc.subject.mesh	Brain Injuries
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Oxidative Stress
dc.subject.mesh	Endoplasmic Reticulum Stress
dc.subject.mesh	Neuroprotection
dc.subject.mesh	Humans
dc.subject.mesh	Neuroprotection
dc.subject.mesh	Mitochondria
dc.subject.mesh	Neurons
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Endoplasmic Reticulum Stress
dc.subject.mesh	Brain Injuries
dc.subject.mesh	Oxidative Stress
dc.title	Understanding the Therapeutic Approaches for Neuroprotection.
dc.type	Journal Article
utslib.citation.volume	29
utslib.location.activity	United Arab Emirates
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
dc.date.updated	2024-05-30T22:40:03Z
pubs.issue	42
pubs.publication-status	Published
pubs.volume	29
utslib.citation.issue	42

Abstract:

The term "neurodegenerative disorders" refers to a group of illnesses in which deterioration of nerve structure and function is a prominent feature. Cognitive capacities such as memory and decision-making deteriorate as a result of neuronal damage. The primary difficulty that remains is safeguarding neurons since they do not proliferate or regenerate spontaneously and are therefore not substituted by the body after they have been damaged. Millions of individuals throughout the world suffer from neurodegenerative diseases. Various pathways lead to neurodegeneration, including endoplasmic reticulum stress, calcium ion overload, mitochondrial dysfunction, reactive oxygen species generation, and apoptosis. Although different treatments and therapies are available for neuroprotection after a brain injury or damage, the obstacles are inextricably connected. Several studies have revealed the pathogenic effects of hypothermia, different breathed gases, stem cell treatments, mitochondrial transplantation, multi-pharmacological therapy, and other therapies that have improved neurological recovery and survival outcomes after brain damage. The present review highlights the use of therapeutic approaches that can be targeted to develop and understand significant therapies for treating neurodegenerative diseases.

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http://hdl.handle.net/10453/179360