Patient-reported use of pancreatic enzyme replacement treatment (PERT) in pancreatic cancer in New Zealand and Australia: a cross-sectional survey study.
- Publisher:
- Springer Nature
- Publication Type:
- Journal Article
- Citation:
- Support Care Cancer, 2024, 32, (6), pp. 402
- Issue Date:
- 2024-06-03
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Full metadata record
| Field | Value | Language |
|---|---|---|
| dc.contributor.author | Landers, A | |
| dc.contributor.author | Brown, H | |
| dc.contributor.author | Al Ruheili, J | |
| dc.contributor.author | Russell, K | |
| dc.contributor.author | McKenzie, C | |
| dc.contributor.author | Agar, MR | |
| dc.contributor.author | Yenson, VM | |
| dc.contributor.author | Clarke, K | |
| dc.contributor.author | Windsor, J | |
| dc.date.accessioned | 2024-06-17T06:01:13Z | |
| dc.date.available | 2024-05-24 | |
| dc.date.available | 2024-06-17T06:01:13Z | |
| dc.date.issued | 2024-06-03 | |
| dc.identifier.citation | Support Care Cancer, 2024, 32, (6), pp. 402 | |
| dc.identifier.issn | 0941-4355 | |
| dc.identifier.issn | 1433-7339 | |
| dc.identifier.uri | http://hdl.handle.net/10453/179533 | |
| dc.description.abstract | PURPOSE: This study investigated pancreatic enzyme replacement therapy (PERT) use in people diagnosed with pancreatic cancer in New Zealand (NZ) and Australia (AU). METHODS: A cross-sectional survey study was conducted using a mixed-media campaign to recruit people with pancreatic cancer and collect information about current PERT use. The questionnaire gathered data on participant demographics, awareness of PERT, prescribing practices and efficacy of enzyme replacement. RESULTS: Over 300 people with pancreatic cancer were recruited, 135 from New Zealand and 199 from Australia. Every region, state and territory was represented except for the West Coast (NZ) and the Northern Territory (AU), the lowest populated areas in both countries. In New Zealand, 60% of participants had heard about PERT, compared to 69.3% in Australia. Dosing regimens were inconsistent in both countries, with 18% and 27% of participants being prescribed PERT considered best practice in New Zealand and Australia, respectively. Before PERT commencement, 70% of participants experienced symptoms of malabsorption, with all symptoms improving after therapy was established. The majority of participants were compliant with their medication. CONCLUSION: PERT use in pancreatic cancer in New Zealand and Australia was highly variable and not compliant with international guidelines in which PERT is recommended as standard therapy. Enzyme replacement is effective for improving the symptoms of malabsorption in patients with pancreatic cancer. Clinician education may be needed to help improve the use of PERT in people with pancreatic cancer. | |
| dc.format | Electronic | |
| dc.language | eng | |
| dc.publisher | Springer Nature | |
| dc.relation.ispartof | Support Care Cancer | |
| dc.relation.isbasedon | 10.1007/s00520-024-08604-1 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences | |
| dc.subject.classification | Oncology & Carcinogenesis | |
| dc.subject.classification | 32 Biomedical and clinical sciences | |
| dc.subject.classification | 42 Health sciences | |
| dc.subject.classification | 52 Psychology | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Cross-Sectional Studies | |
| dc.subject.mesh | Pancreatic Neoplasms | |
| dc.subject.mesh | New Zealand | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Enzyme Replacement Therapy | |
| dc.subject.mesh | Middle Aged | |
| dc.subject.mesh | Australia | |
| dc.subject.mesh | Aged | |
| dc.subject.mesh | Surveys and Questionnaires | |
| dc.subject.mesh | Adult | |
| dc.subject.mesh | Aged, 80 and over | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Pancreatic Neoplasms | |
| dc.subject.mesh | Cross-Sectional Studies | |
| dc.subject.mesh | Adult | |
| dc.subject.mesh | Aged | |
| dc.subject.mesh | Aged, 80 and over | |
| dc.subject.mesh | Middle Aged | |
| dc.subject.mesh | Australia | |
| dc.subject.mesh | New Zealand | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Enzyme Replacement Therapy | |
| dc.subject.mesh | Surveys and Questionnaires | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Cross-Sectional Studies | |
| dc.subject.mesh | Pancreatic Neoplasms | |
| dc.subject.mesh | New Zealand | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Enzyme Replacement Therapy | |
| dc.subject.mesh | Middle Aged | |
| dc.subject.mesh | Australia | |
| dc.subject.mesh | Aged | |
| dc.subject.mesh | Surveys and Questionnaires | |
| dc.subject.mesh | Adult | |
| dc.subject.mesh | Aged, 80 and over | |
| dc.title | Patient-reported use of pancreatic enzyme replacement treatment (PERT) in pancreatic cancer in New Zealand and Australia: a cross-sectional survey study. | |
| dc.type | Journal Article | |
| utslib.citation.volume | 32 | |
| utslib.location.activity | Germany | |
| utslib.for | 11 Medical and Health Sciences | |
| utslib.for | 17 Psychology and Cognitive Sciences | |
| pubs.organisational-group | University of Technology Sydney | |
| pubs.organisational-group | University of Technology Sydney/Faculty of Health | |
| pubs.organisational-group | University of Technology Sydney/Faculty of Health/IMPACCT | |
| utslib.copyright.status | open_access | * |
| dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
| dc.date.updated | 2024-06-17T06:01:10Z | |
| pubs.issue | 6 | |
| pubs.publication-status | Published online | |
| pubs.volume | 32 | |
| utslib.citation.issue | 6 |
Abstract:
PURPOSE: This study investigated pancreatic enzyme replacement therapy (PERT) use in people diagnosed with pancreatic cancer in New Zealand (NZ) and Australia (AU). METHODS: A cross-sectional survey study was conducted using a mixed-media campaign to recruit people with pancreatic cancer and collect information about current PERT use. The questionnaire gathered data on participant demographics, awareness of PERT, prescribing practices and efficacy of enzyme replacement. RESULTS: Over 300 people with pancreatic cancer were recruited, 135 from New Zealand and 199 from Australia. Every region, state and territory was represented except for the West Coast (NZ) and the Northern Territory (AU), the lowest populated areas in both countries. In New Zealand, 60% of participants had heard about PERT, compared to 69.3% in Australia. Dosing regimens were inconsistent in both countries, with 18% and 27% of participants being prescribed PERT considered best practice in New Zealand and Australia, respectively. Before PERT commencement, 70% of participants experienced symptoms of malabsorption, with all symptoms improving after therapy was established. The majority of participants were compliant with their medication. CONCLUSION: PERT use in pancreatic cancer in New Zealand and Australia was highly variable and not compliant with international guidelines in which PERT is recommended as standard therapy. Enzyme replacement is effective for improving the symptoms of malabsorption in patients with pancreatic cancer. Clinician education may be needed to help improve the use of PERT in people with pancreatic cancer.
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