Baduanjin Mind-Body Exercise for Cancer-Related Fatigue: Protocol for a Remotely Delivered Randomized Wait-List Controlled Feasibility Study.

Walsh, S; Wang, K; Lam, A; Du, S; Hu, Y; Sun, Y-T; Tcharkhedian, E; Nikas, E; Webb, G; Moylan, E; Della-Fiorentina, S; Fahey, P; Shelley Wang, X; Chen, M; Zhu, X

Baduanjin Mind-Body Exercise for Cancer-Related Fatigue: Protocol for a Remotely Delivered Randomized Wait-List Controlled Feasibility Study.

Wang, K Lam, A Du, S Hu, Y Sun, Y-T Tcharkhedian, E Nikas, E Webb, G Moylan, E Della-Fiorentina, S Fahey, P Shelley Wang, X Chen, M Zhu, X

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Publisher:: SAGE PUBLICATIONS INC
Publication Type:: Journal Article
Citation:: Integr Cancer Ther, 2024, 23, pp. 15347354231226127
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Walsh, S https://orcid.org/0000-0002-7033-8547
dc.contributor.author	Wang, K
dc.contributor.author	Lam, A
dc.contributor.author	Du, S
dc.contributor.author	Hu, Y
dc.contributor.author	Sun, Y-T
dc.contributor.author	Tcharkhedian, E
dc.contributor.author	Nikas, E
dc.contributor.author	Webb, G
dc.contributor.author	Moylan, E
dc.contributor.author	Della-Fiorentina, S
dc.contributor.author	Fahey, P
dc.contributor.author	Shelley Wang, X
dc.contributor.author	Chen, M
dc.contributor.author	Zhu, X
dc.date.accessioned	2024-07-25T02:09:33Z
dc.date.available	2024-07-25T02:09:33Z
dc.date.issued	2024
dc.identifier.citation	Integr Cancer Ther, 2024, 23, pp. 15347354231226127
dc.identifier.issn	1534-7354
dc.identifier.issn	1552-695X
dc.identifier.uri	http://hdl.handle.net/10453/179843
dc.description.abstract	BACKGROUND: People living with a cancer diagnosis often experience cancer-related fatigue (CRF). Between 9% and 45% of people report CRF as moderate to severe, negatively impacting their quality-of-life (QOL). The evidence-base for managing CRF recommends exercise-related therapies over pharmaceutical interventions. One such exercise-like therapy is Baduanjin mind-body exercise (MBE), which has additional benefits. A remotely delivered program may further benefit people with CRF. The primary objective of this pilot will test study feasibility of a remotely delivered Baduanjin MBE exercise program for people living with CRF. METHODS: This is a randomized wait-list controlled pilot study and will take place in Sydney, Australia. Subject to informed consent, 40 adults with moderate CRF levels and receiving or previously received adjuvant chemotherapy, will undertake a home-based 8-week Baduanjin MBE program supported by online resources and instructors. The primary feasibility outcomes are recruitment, enrollment, retention, and adherence rates; and safety as measured by tolerance and adverse-event frequency. Clinical outcomes (eg, changes in CRF, QOL, and participant perceptions) are assessed at pre-intervention, week 1, week 4, week 8, and post-intervention. Analyses follows the Intent-to-Treat (all participants as per randomization) and per-protocol (participants adhering to the protocol). Missing data will be imputed from previous data entries and regression models may be tested to predict missing outcomes. DISCUSSION: To our knowledge, this is the first study evaluating the feasibility and effects of Baduanjin MBE on CRF using a remote delivery method. These feasibility data will inform a fully powered future trial investigating evidence of effect on CRF and QOL.Trial registration: Australian and New Zealand Clinical Trials Registry (ANZCTR 12623000177651).Ringgold ID: 651498 Chinese Medicine Centre.
dc.format	Print
dc.language	eng
dc.publisher	SAGE PUBLICATIONS INC
dc.relation.ispartof	Integr Cancer Ther
dc.relation.isbasedon	10.1177/15347354231226127
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1104 Complementary and Alternative Medicine, 1112 Oncology and Carcinogenesis
dc.subject.classification	Complementary & Alternative Medicine
dc.subject.classification	3211 Oncology and carcinogenesis
dc.subject.classification	4208 Traditional, complementary and integrative medicine
dc.subject.mesh	Adult
dc.subject.mesh	Humans
dc.subject.mesh	Feasibility Studies
dc.subject.mesh	Quality of Life
dc.subject.mesh	Australia
dc.subject.mesh	Exercise Therapy
dc.subject.mesh	Neoplasms
dc.subject.mesh	Fatigue
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Fatigue
dc.subject.mesh	Exercise Therapy
dc.subject.mesh	Feasibility Studies
dc.subject.mesh	Quality of Life
dc.subject.mesh	Adult
dc.subject.mesh	Australia
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.subject.mesh	Adult
dc.subject.mesh	Humans
dc.subject.mesh	Feasibility Studies
dc.subject.mesh	Quality of Life
dc.subject.mesh	Australia
dc.subject.mesh	Exercise Therapy
dc.subject.mesh	Neoplasms
dc.subject.mesh	Fatigue
dc.subject.mesh	Randomized Controlled Trials as Topic
dc.title	Baduanjin Mind-Body Exercise for Cancer-Related Fatigue: Protocol for a Remotely Delivered Randomized Wait-List Controlled Feasibility Study.
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	United States
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Provost
pubs.organisational-group	University of Technology Sydney/Provost/TD School
utslib.copyright.status	recently_added	*
dc.date.updated	2024-07-25T02:09:29Z
pubs.publication-status	Published
pubs.volume	23

Abstract:

BACKGROUND: People living with a cancer diagnosis often experience cancer-related fatigue (CRF). Between 9% and 45% of people report CRF as moderate to severe, negatively impacting their quality-of-life (QOL). The evidence-base for managing CRF recommends exercise-related therapies over pharmaceutical interventions. One such exercise-like therapy is Baduanjin mind-body exercise (MBE), which has additional benefits. A remotely delivered program may further benefit people with CRF. The primary objective of this pilot will test study feasibility of a remotely delivered Baduanjin MBE exercise program for people living with CRF. METHODS: This is a randomized wait-list controlled pilot study and will take place in Sydney, Australia. Subject to informed consent, 40 adults with moderate CRF levels and receiving or previously received adjuvant chemotherapy, will undertake a home-based 8-week Baduanjin MBE program supported by online resources and instructors. The primary feasibility outcomes are recruitment, enrollment, retention, and adherence rates; and safety as measured by tolerance and adverse-event frequency. Clinical outcomes (eg, changes in CRF, QOL, and participant perceptions) are assessed at pre-intervention, week 1, week 4, week 8, and post-intervention. Analyses follows the Intent-to-Treat (all participants as per randomization) and per-protocol (participants adhering to the protocol). Missing data will be imputed from previous data entries and regression models may be tested to predict missing outcomes. DISCUSSION: To our knowledge, this is the first study evaluating the feasibility and effects of Baduanjin MBE on CRF using a remote delivery method. These feasibility data will inform a fully powered future trial investigating evidence of effect on CRF and QOL.Trial registration: Australian and New Zealand Clinical Trials Registry (ANZCTR 12623000177651).Ringgold ID: 651498 Chinese Medicine Centre.

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http://hdl.handle.net/10453/179843