Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials.

Austin, PD; Lee, W; Costa, DS; Ritchie, A; Lovell, MR

Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials.

Austin, PD Lee, W Costa, DS Ritchie, A Lovell, MR

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Heliyon, 2024, 10, (7), pp. e29193
Issue Date:: 2024-04-15

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Field	Value	Language
dc.contributor.author	Austin, PD
dc.contributor.author	Lee, W
dc.contributor.author	Costa, DS
dc.contributor.author	Ritchie, A
dc.contributor.author	Lovell, MR
dc.date.accessioned	2024-08-06T01:19:36Z
dc.date.available	2024-04-02
dc.date.available	2024-08-06T01:19:36Z
dc.date.issued	2024-04-15
dc.identifier.citation	Heliyon, 2024, 10, (7), pp. e29193
dc.identifier.issn	2405-8440
dc.identifier.issn	2405-8440
dc.identifier.uri	http://hdl.handle.net/10453/180027
dc.description.abstract	PURPOSE: To evaluate effects of aerobic and resistance exercises for cancer-related pain in adults with and surviving cancer. Secondary objectives were to a) evaluate the effect of exercise on fatigue, psychological function, physical function, b) assess fidelity to exercise. DESIGN: A systematic search of MEDLINE, EMBASE, AMED, CINAHL and Cochrane Central Register of Controlled Trials was conducted to identify randomised controlled trials (RCTs) comparing aerobic and/or resistance exercise to control groups. The primary endpoint were changes in cancer-related pain intensity from baseline to post intervention. Meta-regression analysis evaluated predictors for heterogeneity between study findings. Tolerability was defined as reporting of exercise-induced adverse events while fidelity evaluated by reported intervention dropout. RESULTS: Twenty-three RCTs including 1954 patients (age 58 ± 8.5 years; 78 % women); 1087 (56 %) and 867 (44 %) allocated to aerobic/resistance exercise therapy and control group, respectively. Exercise therapy was associated with small to moderate decreases in cancer-related pain compared to controls (SMD = 0.38, 95 % CI: 0.17, 0.58). Although there was significant heterogeneity between individual and pooled study effects (Q = 205.25, p < 0.0001), there was no publication bias. Meta-regression including supervision, age, duration and exercise type as moderators showed no significant differences in reported outcomes. Analysis of secondary outcomes revealed a moderate effect for improvements in physical function, fatigue and psychological symptoms. CONCLUSIONS: Aerobic and resistance exercises are tolerable and effective adjunct therapies to reduce cancer-related pain while also improving physical function, fatigue and mood. Future RCTs of dose, frequency, compliance and exercise type in specific cancer settings are required.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Heliyon
dc.relation.isbasedon	10.1016/j.heliyon.2024.e29193
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2024-08-06T01:19:32Z
pubs.issue	7
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	7

Abstract:

PURPOSE: To evaluate effects of aerobic and resistance exercises for cancer-related pain in adults with and surviving cancer. Secondary objectives were to a) evaluate the effect of exercise on fatigue, psychological function, physical function, b) assess fidelity to exercise. DESIGN: A systematic search of MEDLINE, EMBASE, AMED, CINAHL and Cochrane Central Register of Controlled Trials was conducted to identify randomised controlled trials (RCTs) comparing aerobic and/or resistance exercise to control groups. The primary endpoint were changes in cancer-related pain intensity from baseline to post intervention. Meta-regression analysis evaluated predictors for heterogeneity between study findings. Tolerability was defined as reporting of exercise-induced adverse events while fidelity evaluated by reported intervention dropout. RESULTS: Twenty-three RCTs including 1954 patients (age 58 ± 8.5 years; 78 % women); 1087 (56 %) and 867 (44 %) allocated to aerobic/resistance exercise therapy and control group, respectively. Exercise therapy was associated with small to moderate decreases in cancer-related pain compared to controls (SMD = 0.38, 95 % CI: 0.17, 0.58). Although there was significant heterogeneity between individual and pooled study effects (Q = 205.25, p < 0.0001), there was no publication bias. Meta-regression including supervision, age, duration and exercise type as moderators showed no significant differences in reported outcomes. Analysis of secondary outcomes revealed a moderate effect for improvements in physical function, fatigue and psychological symptoms. CONCLUSIONS: Aerobic and resistance exercises are tolerable and effective adjunct therapies to reduce cancer-related pain while also improving physical function, fatigue and mood. Future RCTs of dose, frequency, compliance and exercise type in specific cancer settings are required.

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http://hdl.handle.net/10453/180027