Factors most strongly associated with breathlessness in a population aged 50-64 years.

Olsson, M; Björkelund, AJ; Sandberg, J; Blomberg, A; Börjesson, M; Currow, D; Malinovschi, A; Sköld, M; Wollmer, P; Torén, K; Östgren, CJ; Engström, G; Ekström, M

Factors most strongly associated with breathlessness in a population aged 50-64 years.

Olsson, M Björkelund, AJ Sandberg, J Blomberg, A Börjesson, M Currow, D

Malinovschi, A Sköld, M Wollmer, P Torén, K Östgren, CJ Engström, G Ekström, M

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Publisher:: EUROPEAN RESPIRATORY SOC JOURNALS LTD
Publication Type:: Journal Article
Citation:: ERJ Open Res, 2024, 10, (2), pp. 582-2023
Issue Date:: 2024-03

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Field	Value	Language
dc.contributor.author	Olsson, M
dc.contributor.author	Björkelund, AJ
dc.contributor.author	Sandberg, J
dc.contributor.author	Blomberg, A
dc.contributor.author	Börjesson, M
dc.contributor.author	Currow, D https://orcid.org/0000-0003-1988-1250
dc.contributor.author	Malinovschi, A
dc.contributor.author	Sköld, M
dc.contributor.author	Wollmer, P
dc.contributor.author	Torén, K
dc.contributor.author	Östgren, CJ
dc.contributor.author	Engström, G
dc.contributor.author	Ekström, M
dc.date.accessioned	2024-08-06T03:21:24Z
dc.date.available	2023-10-31
dc.date.available	2024-08-06T03:21:24Z
dc.date.issued	2024-03
dc.identifier.citation	ERJ Open Res, 2024, 10, (2), pp. 582-2023
dc.identifier.issn	2312-0541
dc.identifier.issn	2312-0541
dc.identifier.uri	http://hdl.handle.net/10453/180110
dc.description.abstract	BACKGROUND: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness. METHODS: A cross-sectional analysis was carried out of the multicentre population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of adults aged 50 to 64 years. Breathlessness was defined as a modified Medical Research Council breathlessness rating ≥2. The machine learning algorithm extreme gradient boosting (XGBoost) was used to classify participants as either breathless or nonbreathless using 449 factors, including physiological measurements, blood samples, computed tomography cardiac and lung measurements, lifestyle, health conditions and socioeconomics. The strength of the associations between the factors and breathlessness were measured by SHapley Additive exPlanations (SHAP), with higher scores reflecting stronger associations. RESULTS: A total of 28 730 participants (52% women) were included in the study. The strongest associated factors for breathlessness were (in order of magnitude): body mass index ( SHAP score 0.39), forced expiratory volume in 1 s (0.32), physical activity measured by accelerometery (0.27), sleep apnoea (0.22), diffusing lung capacity for carbon monoxide (0.21), self-reported physical activity (0.17), chest pain when hurrying (0.17), high-sensitivity C-reactive protein (0.17), recent weight change (0.14) and cough (0.13). CONCLUSION: This large population-based study of men and women aged 50-64 years identified the main factors related to breathlessness that may be prevented or amenable to public health interventions.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	EUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.relation.ispartof	ERJ Open Res
dc.relation.isbasedon	10.1183/23120541.00582-2023
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	3201 Cardiovascular medicine and haematology
dc.subject.classification	3211 Oncology and carcinogenesis
dc.title	Factors most strongly associated with breathlessness in a population aged 50-64 years.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2024-08-06T03:21:21Z
pubs.issue	2
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	2

Abstract:

BACKGROUND: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness. METHODS: A cross-sectional analysis was carried out of the multicentre population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of adults aged 50 to 64 years. Breathlessness was defined as a modified Medical Research Council breathlessness rating ≥2. The machine learning algorithm extreme gradient boosting (XGBoost) was used to classify participants as either breathless or nonbreathless using 449 factors, including physiological measurements, blood samples, computed tomography cardiac and lung measurements, lifestyle, health conditions and socioeconomics. The strength of the associations between the factors and breathlessness were measured by SHapley Additive exPlanations (SHAP), with higher scores reflecting stronger associations. RESULTS: A total of 28 730 participants (52% women) were included in the study. The strongest associated factors for breathlessness were (in order of magnitude): body mass index ( SHAP score 0.39), forced expiratory volume in 1 s (0.32), physical activity measured by accelerometery (0.27), sleep apnoea (0.22), diffusing lung capacity for carbon monoxide (0.21), self-reported physical activity (0.17), chest pain when hurrying (0.17), high-sensitivity C-reactive protein (0.17), recent weight change (0.14) and cough (0.13). CONCLUSION: This large population-based study of men and women aged 50-64 years identified the main factors related to breathlessness that may be prevented or amenable to public health interventions.

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http://hdl.handle.net/10453/180110