Transfer RNA-derived fragments: origins, processing, and functions

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Journal Article
WIREs RNA, 2011, 2 (November/December), pp. 853 - 862
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Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of smallRNAsthat are derived from transferRNAs(tRNAs), tRNAfragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points of possible cross-talk between tRFs and the canonical small RNA pathway characterized by small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). We also propose a nomenclature that is based on their processing characteristics.  2011 John Wiley & Sons, Ltd. WIREs RNA 2011 2 853â862 DOI: 10.1002/wrna.96
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