Transfer RNA-derived fragments: Origins, processing, and functions

Sobala, A; Hutvagner, G

Transfer RNA-derived fragments: Origins, processing, and functions

Sobala, A Hutvagner, G

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Publication Type:: Journal Article
Citation:: Wiley Interdisciplinary Reviews: RNA, 2011, 2 (6), pp. 853 - 862
Issue Date:: 2011-11-01

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Field	Value	Language
dc.contributor.author	Sobala, A	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.date.issued	2011-11-01	en_US
dc.identifier.citation	Wiley Interdisciplinary Reviews: RNA, 2011, 2 (6), pp. 853 - 862	en_US
dc.identifier.issn	1757-7004	en_US
dc.identifier.uri	http://hdl.handle.net/10453/18187
dc.description.abstract	Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points of possible cross-talk between tRFs and the canonical small RNA pathway characterized by small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). We also propose a nomenclature that is based on their processing characteristics. © 2011 John Wiley & Sons, Ltd.	en_US
dc.relation.ispartof	Wiley Interdisciplinary Reviews: RNA	en_US
dc.relation.isbasedon	10.1002/wrna.96	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	RNA, Small Interfering	en_US
dc.subject.mesh	RNA, Transfer	en_US
dc.subject.mesh	RNA Processing, Post-Transcriptional	en_US
dc.subject.mesh	Models, Biological	en_US
dc.subject.mesh	RNA, Small Untranslated	en_US
dc.subject.mesh	Argonaute Proteins	en_US
dc.title	Transfer RNA-derived fragments: Origins, processing, and functions	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	2	en_US
utslib.for	0604 Genetics	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	2	en_US

Abstract:

Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points of possible cross-talk between tRFs and the canonical small RNA pathway characterized by small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). We also propose a nomenclature that is based on their processing characteristics. © 2011 John Wiley & Sons, Ltd.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/18187