DEVELOPMENT OF A 3D BIOPRINTED MODEL TO INVESTIGATE NEURAL CELL RESPONSES TO WEAR DEBRIS FROM SPINAL INSTRUMENTATION AND DEVICES

Wen, D; Madhavan, A; Tavakoli, J; Tipper, J

DEVELOPMENT OF A 3D BIOPRINTED MODEL TO INVESTIGATE NEURAL CELL RESPONSES TO WEAR DEBRIS FROM SPINAL INSTRUMENTATION AND DEVICES

Wen, D Madhavan, A

Tavakoli, J Tipper, J

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Publication Type:: Poster
Citation:: 2023
Issue Date:: 2023-12-04

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Field	Value	Language
dc.contributor.author	Wen, D
dc.contributor.author	Madhavan, A https://orcid.org/0000-0002-9614-9912
dc.contributor.author	Tavakoli, J
dc.contributor.author	Tipper, J
dc.date.accessioned	2025-03-17T01:40:32Z
dc.date.available	2025-03-17T01:40:32Z
dc.date.issued	2023-12-04
dc.identifier.citation	2023
dc.identifier.uri	http://hdl.handle.net/10453/185856
dc.description.abstract	Common biomaterials used in spinal instrumentation and devices consist of metals, polymers, and ceramics. The interfaces of spinal implants, including bearing surfaces, and endplate/bone interface may generate wear debris, which potentially induce adverse biological responses [1]. Although there has been extensive research on hip and knee replacements, information on the biological effects of wear debris produced from spinal implants on neural cells is very limited. Recent 3D models of cast collagen hydrogels with encapsulated cells demonstrated challenges of batch-to-batch variability and inadequate long-term stability [2]. To overcome these issues, 3D bioprinting of hydrogels can provide greater precision in spatial control. Gelatin methacryloyl (GelMA) is a hydrogel that provides tailorable physical properties, and the transparent nature allows efficient examination of cellular activity inside the hydrogel. Thus, our study developed a 3D bioprinted model as a “proof of concept” to investigate neural cell responses to wear debris from spinal implants.
dc.language	en
dc.relation.ispartof	University of Auckland, New Zealand
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.title	DEVELOPMENT OF A 3D BIOPRINTED MODEL TO INVESTIGATE NEURAL CELL RESPONSES TO WEAR DEBRIS FROM SPINAL INSTRUMENTATION AND DEVICES
dc.type	Poster
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	recently_added	*
dc.date.updated	2025-03-17T01:40:31Z

Abstract:

Common biomaterials used in spinal instrumentation and devices consist of metals, polymers, and ceramics. The interfaces of spinal implants, including bearing surfaces, and endplate/bone interface may generate wear debris, which potentially induce adverse biological responses [1]. Although there has been extensive research on hip and knee replacements, information on the biological effects of wear debris produced from spinal implants on neural cells is very limited. Recent 3D models of cast collagen hydrogels with encapsulated cells demonstrated challenges of batch-to-batch variability and inadequate long-term stability [2]. To overcome these issues, 3D bioprinting of hydrogels can provide greater precision in spatial control. Gelatin methacryloyl (GelMA) is a hydrogel that provides tailorable physical properties, and the transparent nature allows efficient examination of cellular activity inside the hydrogel. Thus, our study developed a 3D bioprinted model as a “proof of concept” to investigate neural cell responses to wear debris from spinal implants.

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http://hdl.handle.net/10453/185856