Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.

Arnett, S; Chew, SH; Leitner, U; Hor, JY; Paul, F; Yeaman, MR; Levy, M; Weinshenker, BG; Banwell, BL; Fujihara, K; Abboud, H; Dujmovic Basuroski, I; Arrambide, G; Neubrand, VE; Quan, C; Melamed, E; Palace, J; Sun, J; Asgari, N; Broadley, SA; Guthy Jackson International Clinical Consortium*,

Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.

Arnett, S Chew, SH Leitner, U Hor, JY Paul, F Yeaman, MR Levy, M Weinshenker, BG Banwell, BL Fujihara, K Abboud, H Dujmovic Basuroski, I Arrambide, G Neubrand, VE Quan, C Melamed, E Palace, J Sun, J

Asgari, N Broadley, SA Guthy Jackson International Clinical Consortium*,

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Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: J Neurol, 2024, 271, (8), pp. 4794-4812
Issue Date:: 2024-08

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Field	Value	Language
dc.contributor.author	Arnett, S
dc.contributor.author	Chew, SH
dc.contributor.author	Leitner, U
dc.contributor.author	Hor, JY
dc.contributor.author	Paul, F
dc.contributor.author	Yeaman, MR
dc.contributor.author	Levy, M
dc.contributor.author	Weinshenker, BG
dc.contributor.author	Banwell, BL
dc.contributor.author	Fujihara, K
dc.contributor.author	Abboud, H
dc.contributor.author	Dujmovic Basuroski, I
dc.contributor.author	Arrambide, G
dc.contributor.author	Neubrand, VE
dc.contributor.author	Quan, C
dc.contributor.author	Melamed, E
dc.contributor.author	Palace, J
dc.contributor.author	Sun, J https://orcid.org/0000-0002-0097-2438
dc.contributor.author	Asgari, N
dc.contributor.author	Broadley, SA
dc.contributor.author	Guthy Jackson International Clinical Consortium*,
dc.date.accessioned	2025-03-20T04:51:39Z
dc.date.available	2024-05-16
dc.date.available	2025-03-20T04:51:39Z
dc.date.issued	2024-08
dc.identifier.citation	J Neurol, 2024, 271, (8), pp. 4794-4812
dc.identifier.issn	0340-5354
dc.identifier.issn	1432-1459
dc.identifier.uri	http://hdl.handle.net/10453/186047
dc.description.abstract	BACKGROUND: Aquaporin-4 (AQP4) antibody-associated neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated inflammatory disease of the central nervous system. We have undertaken a systematic review and meta-analysis to ascertain the sex ratio and mean age of onset for AQP4 antibody associated NMOSD. We have also explored factors that impact on these demographic data. METHODS: A systematic search of databases was conducted according to the PRISMA guidelines. Articles reporting sex distribution and age of onset for AQP4 antibody-associated NMSOD were reviewed. An initially inclusive approach involving exploration with regression meta-analysis was followed by an analysis of just AQP4 antibody positive cases. RESULTS: A total of 528 articles were screened to yield 89 articles covering 19,415 individuals from 88 population samples. The female:male sex ratio was significantly influenced by the proportion of AQP4 antibody positive cases in the samples studied (p < 0.001). For AQP4 antibody-positive cases the overall estimate of the sex ratio was 8.89 (95% CI 7.78-10.15). For paediatric populations the estimate was 5.68 (95% CI 4.01-8.03) and for late-onset cases, it was 5.48 (95% CI 4.10-7.33). The mean age of onset was significantly associated with the mean life expectancy of the population sampled (p < 0.001). The mean age of onset for AQP4 antibody-positive cases in long-lived populations was 41.7 years versus 33.3 years in the remainder. CONCLUSIONS: The female:male sex ratio and the mean age of onset of AQP4 antibody-associated NMOSD are significantly higher than MS. The sex ratio increases with the proportion of cases that are positive for AQP4 antibodies and the mean age of onset increases with population life expectancy.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	J Neurol
dc.relation.isbasedon	10.1007/s00415-024-12452-8
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3209 Neurosciences
dc.subject.mesh	Humans
dc.subject.mesh	Neuromyelitis Optica
dc.subject.mesh	Aquaporin 4
dc.subject.mesh	Age of Onset
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Autoantibodies
dc.subject.mesh	Sex Ratio
dc.subject.mesh	Humans
dc.subject.mesh	Neuromyelitis Optica
dc.subject.mesh	Autoantibodies
dc.subject.mesh	Age of Onset
dc.subject.mesh	Sex Ratio
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Aquaporin 4
dc.subject.mesh	Humans
dc.subject.mesh	Neuromyelitis Optica
dc.subject.mesh	Aquaporin 4
dc.subject.mesh	Age of Onset
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Autoantibodies
dc.subject.mesh	Sex Ratio
dc.title	Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.
dc.type	Journal Article
utslib.citation.volume	271
utslib.location.activity	Germany
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	closed_access	*
dc.date.updated	2025-03-20T04:51:37Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	271
utslib.citation.issue	8

Abstract:

BACKGROUND: Aquaporin-4 (AQP4) antibody-associated neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated inflammatory disease of the central nervous system. We have undertaken a systematic review and meta-analysis to ascertain the sex ratio and mean age of onset for AQP4 antibody associated NMOSD. We have also explored factors that impact on these demographic data. METHODS: A systematic search of databases was conducted according to the PRISMA guidelines. Articles reporting sex distribution and age of onset for AQP4 antibody-associated NMSOD were reviewed. An initially inclusive approach involving exploration with regression meta-analysis was followed by an analysis of just AQP4 antibody positive cases. RESULTS: A total of 528 articles were screened to yield 89 articles covering 19,415 individuals from 88 population samples. The female:male sex ratio was significantly influenced by the proportion of AQP4 antibody positive cases in the samples studied (p < 0.001). For AQP4 antibody-positive cases the overall estimate of the sex ratio was 8.89 (95% CI 7.78-10.15). For paediatric populations the estimate was 5.68 (95% CI 4.01-8.03) and for late-onset cases, it was 5.48 (95% CI 4.10-7.33). The mean age of onset was significantly associated with the mean life expectancy of the population sampled (p < 0.001). The mean age of onset for AQP4 antibody-positive cases in long-lived populations was 41.7 years versus 33.3 years in the remainder. CONCLUSIONS: The female:male sex ratio and the mean age of onset of AQP4 antibody-associated NMOSD are significantly higher than MS. The sex ratio increases with the proportion of cases that are positive for AQP4 antibodies and the mean age of onset increases with population life expectancy.

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http://hdl.handle.net/10453/186047