Synthesis of Anisotropic Gold Microparticles via L-Glutathione-Mediated Pathways in Droplet Microfluidics

Yang, Z; Yin, Q; He, M; Chong, SW; Xu, Z; Liu, X; Vega-Sánchez, C; Jaiswal, A; Vigolo, D; Yong, KT

Synthesis of Anisotropic Gold Microparticles via L-Glutathione-Mediated Pathways in Droplet Microfluidics

Yang, Z

Yin, Q He, M Chong, SW Xu, Z Liu, X Vega-Sánchez, C Jaiswal, A Vigolo, D Yong, KT

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Publisher:: WILEY-V C H VERLAG GMBH
Publication Type:: Journal Article
Citation:: Particle and Particle Systems Characterization, 2024, 41, (10)
Issue Date:: 2024-10-01

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Field	Value	Language
dc.contributor.author	Yang, Z https://orcid.org/0000-0003-1335-6893
dc.contributor.author	Yin, Q
dc.contributor.author	He, M
dc.contributor.author	Chong, SW
dc.contributor.author	Xu, Z
dc.contributor.author	Liu, X
dc.contributor.author	Vega-Sánchez, C
dc.contributor.author	Jaiswal, A
dc.contributor.author	Vigolo, D
dc.contributor.author	Yong, KT
dc.date.accessioned	2025-03-27T00:13:28Z
dc.date.available	2025-03-27T00:13:28Z
dc.date.issued	2024-10-01
dc.identifier.citation	Particle and Particle Systems Characterization, 2024, 41, (10)
dc.identifier.issn	0934-0866
dc.identifier.issn	1521-4117
dc.identifier.uri	http://hdl.handle.net/10453/186238
dc.description.abstract	Microfluidic-assisted synthesis of nanoparticles has generated significant interest for its precise control and high throughput capabilities. Among various nanomaterials, gold nanoparticles (AuNPs) have shown remarkable potential in numerous applications, such as disease detection, photothermotherapy, drug delivery, and even defense applications. Recent synthesis strategy of peptide-mediated method has sparked greater interest by offering unique chiroptical properties and their applications in biomedical applications. In this study, the use of droplet microfluidics is explored for the synthesis of peptide-mediated AuNPs, aiming to accelerate automated production via flow chemistry. This method leads to the formation of anisotropic gold particles, with sizes ranging from hundreds of nanometers to the micron scale. The interfacial energy is identified at the water/oil interface as a critical factor influencing this outcome, with L-glutathione (L-GSH) playing a significant role in the development of hyper-branched structures. These results demonstrate the capability of droplet microfluidics in producing anisotropic gold particles at micron scales, presenting new possibilities for the advancement of nanoparticle synthesis techniques.
dc.language	English
dc.publisher	WILEY-V C H VERLAG GMBH
dc.relation.ispartof	Particle and Particle Systems Characterization
dc.relation.isbasedon	10.1002/ppsc.202400056
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0299 Other Physical Sciences, 0904 Chemical Engineering, 0913 Mechanical Engineering
dc.subject.classification	Chemical Engineering
dc.subject.classification	4004 Chemical engineering
dc.subject.classification	4017 Mechanical engineering
dc.subject.classification	4018 Nanotechnology
dc.title	Synthesis of Anisotropic Gold Microparticles via L-Glutathione-Mediated Pathways in Droplet Microfluidics
dc.type	Journal Article
utslib.citation.volume	41
utslib.for	0299 Other Physical Sciences
utslib.for	0904 Chemical Engineering
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2025-03-27T00:13:26Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	41
utslib.citation.issue	10

Abstract:

Microfluidic-assisted synthesis of nanoparticles has generated significant interest for its precise control and high throughput capabilities. Among various nanomaterials, gold nanoparticles (AuNPs) have shown remarkable potential in numerous applications, such as disease detection, photothermotherapy, drug delivery, and even defense applications. Recent synthesis strategy of peptide-mediated method has sparked greater interest by offering unique chiroptical properties and their applications in biomedical applications. In this study, the use of droplet microfluidics is explored for the synthesis of peptide-mediated AuNPs, aiming to accelerate automated production via flow chemistry. This method leads to the formation of anisotropic gold particles, with sizes ranging from hundreds of nanometers to the micron scale. The interfacial energy is identified at the water/oil interface as a critical factor influencing this outcome, with L-glutathione (L-GSH) playing a significant role in the development of hyper-branched structures. These results demonstrate the capability of droplet microfluidics in producing anisotropic gold particles at micron scales, presenting new possibilities for the advancement of nanoparticle synthesis techniques.

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http://hdl.handle.net/10453/186238