Burden of neurological disorders in China and its provinces, 1990-2021: Findings from the global burden of disease study 2021.

Zhang, C; Yang, X; Wan, D; Ma, Q; Yin, P; GBD 2021 China Neurological Disorders Collaborators,; Zhou, M; Hao, J

Burden of neurological disorders in China and its provinces, 1990-2021: Findings from the global burden of disease study 2021.

Zhang, C Yang, X Wan, D Ma, Q Yin, P GBD 2021 China Neurological Disorders Collaborators, Zhou, M Hao, J

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Publisher:: CELL PRESS
Publication Type:: Journal Article
Citation:: Med, 2025, 6, (8), pp. 100692
Issue Date:: 2025-08-08

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Field	Value	Language
dc.contributor.author	Zhang, C
dc.contributor.author	Yang, X
dc.contributor.author	Wan, D
dc.contributor.author	Ma, Q
dc.contributor.author	Yin, P
dc.contributor.author	GBD 2021 China Neurological Disorders Collaborators,
dc.contributor.author	Zhou, M
dc.contributor.author	Hao, J
dc.date.accessioned	2026-01-28T07:47:23Z
dc.date.available	2025-04-08
dc.date.available	2026-01-28T07:47:23Z
dc.date.issued	2025-08-08
dc.identifier.citation	Med, 2025, 6, (8), pp. 100692
dc.identifier.issn	2666-6359
dc.identifier.issn	2666-6340
dc.identifier.uri	http://hdl.handle.net/10453/192492
dc.description.abstract	BACKGROUND: The burden of neurological disorders in China has not been systematically analyzed. We aim to provide a comprehensive estimation of the national and subnational neurological burden across China from the Global Burden of Disease Study (GBD) 2021. METHODS: We assessed burden estimates for 16 neurological disorders by age, sex, and province from 1990 to 2021, with prevalence, death, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs). We performed decomposition analysis to determine contributing factors for DALYs and used the socio-demographic index (SDI) to assess relations with development level. FINDINGS: In 2021, there were 468.29 million prevalent cases of neurological disorders in China, corresponding to 78.10 million DALYs. Intracerebral hemorrhage was the leading cause of DALYs, followed by ischemic stroke, dementias, and migraine. DALYs of neurological disorders were higher in males than females, peaking at 70-74 years. From 1990 to 2021, the number and age-standardized rate of DALYs significantly decreased for idiopathic epilepsy and subarachnoid hemorrhage, primarily attributed to the reduction in YLLs, while the number of DALYs disproportionately increased for dementias, Parkinson's disease, and ischemic stroke contributed by population aging. The age-standardized DALY rates of seven neurological disorders had more than 5-fold variation between western and eastern provinces, despite reduced burdens with rising SDI. CONCLUSIONS: Neurological disorders pose a large and growing burden on public health, primarily driven by population aging. Our findings could inform priority setting and targeted strategies to optimize neurological service delivery. FUNDING: The funding information is presented in the acknowledgments.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	CELL PRESS
dc.relation.ispartof	Med
dc.relation.isbasedon	10.1016/j.medj.2025.100692
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Humans
dc.subject.mesh	China
dc.subject.mesh	Male
dc.subject.mesh	Female
dc.subject.mesh	Nervous System Diseases
dc.subject.mesh	Disability-Adjusted Life Years
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Global Burden of Disease
dc.subject.mesh	Adult
dc.subject.mesh	Prevalence
dc.subject.mesh	Adolescent
dc.subject.mesh	Young Adult
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Cost of Illness
dc.subject.mesh	Infant
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Child
dc.subject.mesh	Quality-Adjusted Life Years
dc.subject.mesh	Humans
dc.subject.mesh	Nervous System Diseases
dc.subject.mesh	Prevalence
dc.subject.mesh	Quality-Adjusted Life Years
dc.subject.mesh	Cost of Illness
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Middle Aged
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Infant
dc.subject.mesh	China
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Young Adult
dc.subject.mesh	Global Burden of Disease
dc.subject.mesh	Disability-Adjusted Life Years
dc.subject.mesh	Humans
dc.subject.mesh	China
dc.subject.mesh	Male
dc.subject.mesh	Female
dc.subject.mesh	Nervous System Diseases
dc.subject.mesh	Disability-Adjusted Life Years
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Global Burden of Disease
dc.subject.mesh	Adult
dc.subject.mesh	Prevalence
dc.subject.mesh	Adolescent
dc.subject.mesh	Young Adult
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Cost of Illness
dc.subject.mesh	Infant
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Child
dc.subject.mesh	Quality-Adjusted Life Years
dc.title	Burden of neurological disorders in China and its provinces, 1990-2021: Findings from the global burden of disease study 2021.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2026-01-28T07:47:22Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	8

Abstract:

BACKGROUND: The burden of neurological disorders in China has not been systematically analyzed. We aim to provide a comprehensive estimation of the national and subnational neurological burden across China from the Global Burden of Disease Study (GBD) 2021. METHODS: We assessed burden estimates for 16 neurological disorders by age, sex, and province from 1990 to 2021, with prevalence, death, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs). We performed decomposition analysis to determine contributing factors for DALYs and used the socio-demographic index (SDI) to assess relations with development level. FINDINGS: In 2021, there were 468.29 million prevalent cases of neurological disorders in China, corresponding to 78.10 million DALYs. Intracerebral hemorrhage was the leading cause of DALYs, followed by ischemic stroke, dementias, and migraine. DALYs of neurological disorders were higher in males than females, peaking at 70-74 years. From 1990 to 2021, the number and age-standardized rate of DALYs significantly decreased for idiopathic epilepsy and subarachnoid hemorrhage, primarily attributed to the reduction in YLLs, while the number of DALYs disproportionately increased for dementias, Parkinson's disease, and ischemic stroke contributed by population aging. The age-standardized DALY rates of seven neurological disorders had more than 5-fold variation between western and eastern provinces, despite reduced burdens with rising SDI. CONCLUSIONS: Neurological disorders pose a large and growing burden on public health, primarily driven by population aging. Our findings could inform priority setting and targeted strategies to optimize neurological service delivery. FUNDING: The funding information is presented in the acknowledgments.

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http://hdl.handle.net/10453/192492