TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production

Manetsch, M; Seidel, P; Heintz, U; Che, W; Hughes, J; Ge, Q; Sukkar, M; Ammit, A

TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production

Manetsch, M Seidel, P Heintz, U Che, W Hughes, J Ge, Q Sukkar, M Ammit, A

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Publisher:: American Physiological Society
Publication Type:: Journal Article
Citation:: Ammit, Alaina et al. 2012, 'TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production', American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 302, no. 9, pp. L838-L845.
Issue Date:: 2012

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Field	Value	Language
dc.contributor.author	Manetsch, M	en_US
dc.contributor.author	Seidel, P	en_US
dc.contributor.author	Heintz, U	en_US
dc.contributor.author	Che, W	en_US
dc.contributor.author	Hughes, J	en_US
dc.contributor.author	Ge, Q	en_US
dc.contributor.author	Sukkar, M	en_US
dc.contributor.author	Ammit, A	en_US
dc.date.accessioned	2014-04-03T01:05:19Z
dc.date.available	2014-04-03T01:05:19Z
dc.date.issued	2012	en_US
dc.identifier	2011006543	en_US
dc.identifier.citation	Ammit, Alaina et al. 2012, 'TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production', American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 302, no. 9, pp. L838-L845.	en_US
dc.identifier.issn	1040-0605	en_US
dc.identifier.other	C1UNSUBMIT	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22153
dc.description.abstract	Airway smooth muscle (ASM) cells express Toll-like receptors (TLRs) and may be involved in the amplification of airway inflammatory responses during infectious exacerbations. We determined whether infectious stimuli (mimicked using Pam3CSK4, a synthetic bacterial lipopeptide that binds to TLR2/TLR1) further enhance ASM cell inflammatory responses to TNFI? in vitro and the signaling pathways involved. Our findings suggest that ASM cells may be involved in the amplification of airway inflammatory responses during infectious exacerbations in chronic airway disease.	en_US
dc.publisher	American Physiological Society	en_US
dc.relation.ispartof	American Journal of Physiology: Lung Cellular and Molecular Physiology	en_US
dc.relation.ispartof	Verified OK	en_US
dc.relation.isbasedon	http://dx.doi.org/10.1152/ajplung.00317.2011	en_US
dc.subject	interleukin-6 and -8; adenosine 3',5'-cyclic monophosphate response element binding; nuclear factor-kB; neutrophil chemotaxis; Toll-like receptors; tumor necrosis factor-I?	en_US
dc.subject.classification	Physiology	en_US
dc.title	TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production	en_US
dc.type	Journal article
utslib.citation.volume	302	en_US
utslib.citation.number	9	en_US
utslib.location	Bethesda, MD, USA	en_US
utslib.citation.startpage	L838	en_US
utslib.citation.endpage	L845	en_US
utslib.identifier.org	GSH.Pharmacy	en_US
utslib.for	060600	en_US
utslib.percentage	50	en_US
utslib.copyright.status	closed_access

Abstract:

Airway smooth muscle (ASM) cells express Toll-like receptors (TLRs) and may be involved in the amplification of airway inflammatory responses during infectious exacerbations. We determined whether infectious stimuli (mimicked using Pam3CSK4, a synthetic bacterial lipopeptide that binds to TLR2/TLR1) further enhance ASM cell inflammatory responses to TNFI? in vitro and the signaling pathways involved. Our findings suggest that ASM cells may be involved in the amplification of airway inflammatory responses during infectious exacerbations in chronic airway disease.

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http://hdl.handle.net/10453/22153