TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production
- American Physiological Society
- Publication Type:
- Journal Article
- Ammit, Alaina et al. 2012, 'TLR2 ligand engagement upregulates airway smooth muscle TNFa-induced cytokine production', American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 302, no. 9, pp. L838-L845.
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Airway smooth muscle (ASM) cells express Toll-like receptors (TLRs) and may be involved in the amplification of airway inflammatory responses during infectious exacerbations. We determined whether infectious stimuli (mimicked using Pam3CSK4, a synthetic bacterial lipopeptide that binds to TLR2/TLR1) further enhance ASM cell inflammatory responses to TNFI? in vitro and the signaling pathways involved. Our findings suggest that ASM cells may be involved in the amplification of airway inflammatory responses during infectious exacerbations in chronic airway disease.
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