Treating asthma means treating airway smooth muscle cells

Zuyderduyn, S; Sukkar, MB; Fust, A; Dhaliwal, S; Burgess, JK

Treating asthma means treating airway smooth muscle cells

Zuyderduyn, S Sukkar, MB

Fust, A Dhaliwal, S Burgess, JK

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Publication Type:: Journal Article
Citation:: European Respiratory Journal, 2008, 32 (2), pp. 265 - 274
Issue Date:: 2008-08-01

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Field	Value	Language
dc.contributor.author	Zuyderduyn, S	en_US
dc.contributor.author	Sukkar, MB https://orcid.org/0000-0003-4591-2399	en_US
dc.contributor.author	Fust, A	en_US
dc.contributor.author	Dhaliwal, S	en_US
dc.contributor.author	Burgess, JK	en_US
dc.date.issued	2008-08-01	en_US
dc.identifier.citation	European Respiratory Journal, 2008, 32 (2), pp. 265 - 274	en_US
dc.identifier.issn	0903-1936	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22478
dc.description.abstract	Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway remodelling. Airway smooth muscle cells are known to be the main effector cells of airway narrowing. In the present paper, studies will be discussed that have led to a novel view of the role of airway smooth muscle in the pathogenesis of asthma in which airway hyperresponsiveness, remodelling and inflammation are, at least in part, attributable to airway smooth muscle. Furthermore, how this new view may lead to a change in the phenotyping and treatment of patients with asthma will be discussed. Copyright©ERS Journals Ltd 2008.	en_US
dc.relation.ispartof	European Respiratory Journal	en_US
dc.relation.isbasedon	10.1183/09031936.00051407	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Respiratory System	en_US
dc.subject.mesh	Pulmonary Alveoli	en_US
dc.subject.mesh	Cell Membrane	en_US
dc.subject.mesh	Myocytes, Smooth Muscle	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Nematode Infections	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Hypertrophy	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Phenotype	en_US
dc.subject.mesh	Models, Biological	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.title	Treating asthma means treating airway smooth muscle cells	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	32	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	1116 Medical Physiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	32	en_US

Abstract:

Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway remodelling. Airway smooth muscle cells are known to be the main effector cells of airway narrowing. In the present paper, studies will be discussed that have led to a novel view of the role of airway smooth muscle in the pathogenesis of asthma in which airway hyperresponsiveness, remodelling and inflammation are, at least in part, attributable to airway smooth muscle. Furthermore, how this new view may lead to a change in the phenotyping and treatment of patients with asthma will be discussed. Copyright©ERS Journals Ltd 2008.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/22478