Soluble RAGE is deficient in neutrophilic asthma and COPD

Publisher:
European Respiratory Society
Publication Type:
Journal Article
Citation:
European Respiratory Journal, 2012, 39 pp. 721 - 729
Issue Date:
2012-01
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The receptor for advanced glycation end-products (RAGE) is a pattern-recognition receptor involved in the host response to injury, infection and inflammation. It is a membrane receptor, but also has soluble forms (sRAGE). Deficiencies in sRAGE are linked to heightened inflammation in various chronic conditions. We determined whether airway and systemic levels of sRAGE and the RAGE ligands HMGB1 (high-mobility group box-1) and serum amyloid A (SAA) are related to neutrophilic inflammation in asthma and chronic obstructive pulmonary disease (COPD).
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