Symptomatic remission and patient quality of life in an observational study of schizophrenia: is there a relationship?

Haro, JM; Novick, D; Perrin, E; Bertsch, J; Knapp, M

Symptomatic remission and patient quality of life in an observational study of schizophrenia: is there a relationship?

Haro, JM Novick, D Perrin, E Bertsch, J Knapp, M

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Publication Type:: Journal Article
Citation:: Psychiatry Res, 2014, 220 (1-2), pp. 163 - 169
Issue Date:: 2014-12-15

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Field	Value	Language
dc.contributor.author	Haro, JM	en_US
dc.contributor.author	Novick, D	en_US
dc.contributor.author	Perrin, E	en_US
dc.contributor.author	Bertsch, J	en_US
dc.contributor.author	Knapp, M	en_US
dc.date.available	2014-07-19	en_US
dc.date.issued	2014-12-15	en_US
dc.identifier.citation	Psychiatry Res, 2014, 220 (1-2), pp. 163 - 169	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22759
dc.description.abstract	This analysis aimed to examine the association between remission and quality of life (QOL) in schizophrenia. In post-hoc analyses of the 3-year, prospective, observational Schizophrenia Outpatients Health Outcomes (SOHO) study, we compared the QOL of patients who achieved symptomatic and clinical remission with those who did not, and the factors associated. Symptomatic remission was defined as achieving a score of ≤3 on the Clinical Global Impression-Schizophrenia (CGI-SCH) scale, maintained for 6 months and without hospitalization. QOL was patient self-rated using the European-QOL. Of the 6516 patients analyzed, 38% were in symptomatic remission 12 months post-baseline and 52% at 36 months. Functional remission remained fairly constant from 12 months to 36 months (22.4% at both time points). At all visits from 12 to 36 months, patient QOL and social functioning were significantly higher for patients in symptomatic remission. QOL was higher in patients in functional remission. Patients with maintained symptomatic remission over the 3-year follow-up had a much greater improvement in QOL than patients with no symptomatic remission or symptomatic remission for part of the period. Factors associated with a better QOL also included paid employment, socially active, a higher CGI-SCH cognitive score, good compliance, and a better baseline QOL.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Psychiatry Res	en_US
dc.relation.isbasedon	10.1016/j.psychres.2014.07.034	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Remission Induction	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Patient Compliance	en_US
dc.subject.mesh	Schizophrenia	en_US
dc.subject.mesh	Neuropsychological Tests	en_US
dc.subject.mesh	Schizophrenic Psychology	en_US
dc.subject.mesh	Quality of Life	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Outpatients	en_US
dc.subject.mesh	Employment	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Symptomatic remission and patient quality of life in an observational study of schizophrenia: is there a relationship?	en_US
dc.type	Journal Article
utslib.citation.volume	1-2	en_US
utslib.citation.volume	220	en_US
utslib.location.activity	Ireland	en_US
utslib.for	2002 Cultural Studies	en_US
utslib.for	2005 Literary Studies	en_US
dc.location.activity	San Diego, CA
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Arts and Social Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Arts and Social Sciences/Cultural Studies Program
utslib.copyright.status	closed_access
pubs.issue	1-2	en_US
pubs.publication-status	Published	en_US
pubs.volume	220	en_US

Abstract:

This analysis aimed to examine the association between remission and quality of life (QOL) in schizophrenia. In post-hoc analyses of the 3-year, prospective, observational Schizophrenia Outpatients Health Outcomes (SOHO) study, we compared the QOL of patients who achieved symptomatic and clinical remission with those who did not, and the factors associated. Symptomatic remission was defined as achieving a score of ≤3 on the Clinical Global Impression-Schizophrenia (CGI-SCH) scale, maintained for 6 months and without hospitalization. QOL was patient self-rated using the European-QOL. Of the 6516 patients analyzed, 38% were in symptomatic remission 12 months post-baseline and 52% at 36 months. Functional remission remained fairly constant from 12 months to 36 months (22.4% at both time points). At all visits from 12 to 36 months, patient QOL and social functioning were significantly higher for patients in symptomatic remission. QOL was higher in patients in functional remission. Patients with maintained symptomatic remission over the 3-year follow-up had a much greater improvement in QOL than patients with no symptomatic remission or symptomatic remission for part of the period. Factors associated with a better QOL also included paid employment, socially active, a higher CGI-SCH cognitive score, good compliance, and a better baseline QOL.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/22759