Fabrication of nanoelectrode ensembles formed via PAN-co-PAA self-assembly and selective voltammetric detection of uric acid in biologic samples

Hu, X; Liu, L; Xue, H; Wang, G; Wang, C

Fabrication of nanoelectrode ensembles formed via PAN-co-PAA self-assembly and selective voltammetric detection of uric acid in biologic samples

Hu, X Liu, L Xue, H Wang, G Wang, C

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Publisher:: Elsevier Science
Publication Type:: Journal Article
Citation:: Hu, Xiaoya et al. 2013, 'Fabrication of nanoelectrode ensembles formed via PAN-co-PAA self-assembly and selective voltammetric detection of uric acid in biologic samples', Elsevier Science, vol. 181, pp. 194-201.
Issue Date:: 2013

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Field	Value	Language
dc.contributor.author	Hu, X	en_US
dc.contributor.author	Liu, L	en_US
dc.contributor.author	Xue, H	en_US
dc.contributor.author	Wang, G	en_US
dc.contributor.author	Wang, C	en_US
dc.date.accessioned	2013-11-03T17:05:34Z
dc.date.available	2013-11-03T17:05:34Z
dc.date.issued	2013	en_US
dc.identifier	2012001628	en_US
dc.identifier.citation	Hu, Xiaoya et al. 2013, 'Fabrication of nanoelectrode ensembles formed via PAN-co-PAA self-assembly and selective voltammetric detection of uric acid in biologic samples', Elsevier Science, vol. 181, pp. 194-201.	en_US
dc.identifier.issn	0925-4005	en_US
dc.identifier.other	C1	en_US
dc.identifier.uri	http://hdl.handle.net/10453/24049
dc.description.abstract	In this work, we have developed a novel approach that fabricating carbon nanoelectrode ensembles (carbon NEEs) with the pores of 50?120 nm in radii by self-assembling a copolymer [poly(acrylonitrile-coacrylic acid)]. Only conventional, inexpensive electrochemical instrument is required for this procedure, which is simple and fast. The electrochemical behavior of AA and UA at this carbon NEEs has been studied by CV and differential pulse voltammetry (DPV). The carbon NEEs can suppress the response of ascorbic acid (AA) drastically and resolve the overlapping voltammetric response of uric acid (UA) and AA into two well-defined peaks with a large anodic peak difference (!Epa) of about 330 mV. Meanwhile, the carbonbased electrodes have the weak absorption and fast electron transfer. The reaction of UA and AA take place in the different micro-environment in the presence of the carboxylic functional groups in the nanopores. The sensor offers the peak current that was linearly dependent on the UA concentration in the range from 5.0 ? 10-7 mol/L to 5.0 ? 10-5 mol/L at neutral pH (PBS, pH 6.86) with a correlation coefficient of 0.998, and the detection limit was 1.0 ?10-7 mol/L (S/N = 3). The carbon NEEs shows excellent sensitivity and selectivity and has been used for the determination of UA in real serum and urine samples with satisfied results.	en_US
dc.publisher	Elsevier Science	en_US
dc.relation.ispartof	Verified OK	en_US
dc.relation.ispartof	Sensors and Actuators B: Chemical	en_US
dc.subject	Poly(acrylonitrile-co-acrylic acid) Nanoelectrode ensembles Copolymer Voltammetry Uric acid	en_US
dc.subject.classification	Materials Engineering	en_US
dc.title	Fabrication of nanoelectrode ensembles formed via PAN-co-PAA self-assembly and selective voltammetric detection of uric acid in biologic samples	en_US
dc.type	Journal article
utslib.citation.volume	181	en_US
utslib.location	Switzerland	en_US
utslib.citation.startpage	194	en_US
utslib.citation.endpage	201	en_US
utslib.identifier.org	SCI.School of Chemistry and Forensic Science SCI.School of Chemistry and Forensic Science SCI.School of Chemistry and Forensic Science	en_US
utslib.for	091200	en_US
utslib.percentage	50	en_US
utslib.copyright.status	closed_access

Abstract:

In this work, we have developed a novel approach that fabricating carbon nanoelectrode ensembles (carbon NEEs) with the pores of 50?120 nm in radii by self-assembling a copolymer [poly(acrylonitrile-coacrylic acid)]. Only conventional, inexpensive electrochemical instrument is required for this procedure, which is simple and fast. The electrochemical behavior of AA and UA at this carbon NEEs has been studied by CV and differential pulse voltammetry (DPV). The carbon NEEs can suppress the response of ascorbic acid (AA) drastically and resolve the overlapping voltammetric response of uric acid (UA) and AA into two well-defined peaks with a large anodic peak difference (!Epa) of about 330 mV. Meanwhile, the carbonbased electrodes have the weak absorption and fast electron transfer. The reaction of UA and AA take place in the different micro-environment in the presence of the carboxylic functional groups in the nanopores. The sensor offers the peak current that was linearly dependent on the UA concentration in the range from 5.0 ? 10-7 mol/L to 5.0 ? 10-5 mol/L at neutral pH (PBS, pH 6.86) with a correlation coefficient of 0.998, and the detection limit was 1.0 ?10-7 mol/L (S/N = 3). The carbon NEEs shows excellent sensitivity and selectivity and has been used for the determination of UA in real serum and urine samples with satisfied results.

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http://hdl.handle.net/10453/24049