Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance

Bryant, C; Suen, H; Brown, R; Yang, S; Favaloro, J; Aklilu, E; Gibson, J; Ho, P; Iland, H; Fromm, P; Woodland, N; Nassif, N; Hart, D; Joshua, D

Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance

Bryant, C Suen, H Brown, R Yang, S Favaloro, J Aklilu, E Gibson, J Ho, P Iland, H Fromm, P Woodland, N Nassif, N Hart, D Joshua, D

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Publisher:: Nature Publishing Group
Publication Type:: Journal Article
Citation:: Bryant, C et al. 2013, 'Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance', Blood Cancer Journal, vol. 3, no. 1, pp. e148-1-e148-7.
Issue Date:: 2013

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Field	Value	Language
dc.contributor.author	Bryant, C	en_US
dc.contributor.author	Suen, H	en_US
dc.contributor.author	Brown, R	en_US
dc.contributor.author	Yang, S	en_US
dc.contributor.author	Favaloro, J	en_US
dc.contributor.author	Aklilu, E	en_US
dc.contributor.author	Gibson, J	en_US
dc.contributor.author	Ho, P	en_US
dc.contributor.author	Iland, H	en_US
dc.contributor.author	Fromm, P	en_US
dc.contributor.author	Woodland, N	en_US
dc.contributor.author	Nassif, N	en_US
dc.contributor.author	Hart, D	en_US
dc.contributor.author	Joshua, D	en_US
dc.date.accessioned	2014-04-14T02:54:29Z
dc.date.available	2014-04-14T02:54:29Z
dc.date.issued	2013	en_US
dc.identifier	2013001042	en_US
dc.identifier.citation	Bryant, C et al. 2013, 'Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance', Blood Cancer Journal, vol. 3, no. 1, pp. e148-1-e148-7.	en_US
dc.identifier.issn	2044-5385	en_US
dc.identifier.other	C1	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27296
dc.description.abstract	Despite improved outcomes in multiple myeloma (MM), a cure remains elusive. However, even before the current therapeutic era, 5% of patients survived >10 years and we propose that immune factors contribute to this longer survival. We identified patients	en_US
dc.publisher	Nature Publishing Group	en_US
dc.relation.ispartof	Verified OK	en_US
dc.relation.ispartof	Blood Cancer Journal	en_US
dc.relation.isbasedon	http://dx.doi.org/10.1038/bcj.2013.34	en_US
dc.subject	Immature Dendritic Cells; Bone-Marrow; 10-Year Survival; Disease Burden; Therapy; Thalidomide; Expansions; Frequency; Transplantation; Lymphocytes	en_US
dc.subject.classification	Clinical Sciences	en_US
dc.title	Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance	en_US
dc.type	Journal article
utslib.citation.volume	3	en_US
utslib.citation.number	1	en_US
utslib.location	London	en_US
utslib.citation.startpage	e148-1	en_US
utslib.citation.endpage	e148-7	en_US
utslib.identifier.org	SCI.Faculty of Science	en_US
utslib.for	110300	en_US
utslib.percentage	100	en_US
utslib.copyright.status	open_access

Abstract:

Despite improved outcomes in multiple myeloma (MM), a cure remains elusive. However, even before the current therapeutic era, 5% of patients survived >10 years and we propose that immune factors contribute to this longer survival. We identified patients

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http://hdl.handle.net/10453/27296