Synthesis, characterization, and mineralization of polyamide-6/calcium lactate composite nanofibers for bone tissue engineering

Pant, HR; Risal, P; Park, CH; Tijing, LD; Jeong, YJ; Kim, CS

Synthesis, characterization, and mineralization of polyamide-6/calcium lactate composite nanofibers for bone tissue engineering

Pant, HR Risal, P Park, CH Tijing, LD

Jeong, YJ Kim, CS

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Publication Type:: Journal Article
Citation:: Colloids and Surfaces B: Biointerfaces, 2013, 102 pp. 152 - 157
Issue Date:: 2013-02-01

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Field	Value	Language
dc.contributor.author	Pant, HR	en_US
dc.contributor.author	Risal, P	en_US
dc.contributor.author	Park, CH	en_US
dc.contributor.author	Tijing, LD https://orcid.org/0000-0001-9398-6355	en_US
dc.contributor.author	Jeong, YJ	en_US
dc.contributor.author	Kim, CS	en_US
dc.date.available	2012-08-07	en_US
dc.date.issued	2013-02-01	en_US
dc.identifier.citation	Colloids and Surfaces B: Biointerfaces, 2013, 102 pp. 152 - 157	en_US
dc.identifier.issn	0927-7765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27897
dc.description.abstract	Polyamide-6 nanofibers containing calcium lactate (CL) on their surface were prepared by neutralization of lactic acid (LA) in core-shell structured polyamide-6/LA electrospun fibers. First, simple blending of LA with polyamide-6 solution was used for electrospinning which interestingly formed a thin LA layer around polyamide-6 nanofibers (core-shell structure) and then subsequent conversion of this LA into calcium lactate via neutralization using calcium base. FE-SEM and TEM images revealed that plasticizer capacity of LA led the formation of point-bonded structure due to the formation of shell layer of LA and core of polyamide-6. The bone formation ability of polyamide-6/calcium lactate composite fibers was evaluated by incubating in biomimetic simulated body fluid (SBF). The SBF incubation test confirmed the faster deposition of large amount of calcium phosphate around the composite polyamide-6/calcium lactate fibers compared to pristine polyamide-6. This study demonstrated a simple post electrospinning calcium compound coating technique of polymeric nanofibers for enhancing the bone biocompatibility of polyamide-6 fibers. © 2012 Elsevier B.V.	en_US
dc.relation.ispartof	Colloids and Surfaces B: Biointerfaces	en_US
dc.relation.isbasedon	10.1016/j.colsurfb.2012.08.032	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Bone and Bones	en_US
dc.subject.mesh	Calcium Compounds	en_US
dc.subject.mesh	Caprolactam	en_US
dc.subject.mesh	Lactates	en_US
dc.subject.mesh	Polymers	en_US
dc.subject.mesh	Biocompatible Materials	en_US
dc.subject.mesh	Microscopy, Electron, Scanning	en_US
dc.subject.mesh	Microscopy, Electron, Transmission	en_US
dc.subject.mesh	Spectroscopy, Fourier Transform Infrared	en_US
dc.subject.mesh	Tissue Engineering	en_US
dc.subject.mesh	Nanofibers	en_US
dc.title	Synthesis, characterization, and mineralization of polyamide-6/calcium lactate composite nanofibers for bone tissue engineering	en_US
dc.type	Journal Article
utslib.citation.volume	102	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	102	en_US

Abstract:

Polyamide-6 nanofibers containing calcium lactate (CL) on their surface were prepared by neutralization of lactic acid (LA) in core-shell structured polyamide-6/LA electrospun fibers. First, simple blending of LA with polyamide-6 solution was used for electrospinning which interestingly formed a thin LA layer around polyamide-6 nanofibers (core-shell structure) and then subsequent conversion of this LA into calcium lactate via neutralization using calcium base. FE-SEM and TEM images revealed that plasticizer capacity of LA led the formation of point-bonded structure due to the formation of shell layer of LA and core of polyamide-6. The bone formation ability of polyamide-6/calcium lactate composite fibers was evaluated by incubating in biomimetic simulated body fluid (SBF). The SBF incubation test confirmed the faster deposition of large amount of calcium phosphate around the composite polyamide-6/calcium lactate fibers compared to pristine polyamide-6. This study demonstrated a simple post electrospinning calcium compound coating technique of polymeric nanofibers for enhancing the bone biocompatibility of polyamide-6 fibers. © 2012 Elsevier B.V.

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http://hdl.handle.net/10453/27897