Assessment of the interaction between aquatic colloids and pharmaceuticals facilitated by cross-flow ultrafiltration

Maskaoui, K; Hibberd, A; Zhou, JL

Assessment of the interaction between aquatic colloids and pharmaceuticals facilitated by cross-flow ultrafiltration

Maskaoui, K Hibberd, A Zhou, JL

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Publication Type:: Journal Article
Citation:: Environmental Science and Technology, 2007, 41 (23), pp. 8038 - 8043
Issue Date:: 2007-12-01

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Field	Value	Language
dc.contributor.author	Maskaoui, K	en_US
dc.contributor.author	Hibberd, A	en_US
dc.contributor.author	Zhou, JL https://orcid.org/0000-0003-1393-1608	en_US
dc.date.issued	2007-12-01	en_US
dc.identifier.citation	Environmental Science and Technology, 2007, 41 (23), pp. 8038 - 8043	en_US
dc.identifier.issn	0013-936X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28393
dc.description.abstract	Interactions between pharmaceuticals and aquatic colloids are a key process regulating their environmental fate, but poorly understood. A validated cross-flow ultrafiltration (CFUF) system was used to isolate river colloids and to determine the partition of selected pharmaceuticals between colloidal (>1 kDa but <0.7 μm) and dissolved phases (<1 kDa) by liquid chromatography-tandem mass spectrometry (LC-MS-MS). The kinetics of pharmaceutical binding to colloids was rapid, reaching equilibrium within 5 min. The mass balance of chosen pharmaceuticals through CFLUF system was satisfactory for propranolol, sulfamethoxazole, meberverine, carbamazepine, indomethacine, diclofenac, and meclofenamic acid. The partition coefficient normalized to colloidal organic carbon content (Kcoc) varied from 5.45 × 104 to 7.54 × 105 mL/g for the chosen pharmaceuticals, which are greater than those for endocrine disrupting chemicals (EDCs), suggesting substantially stronger colloidal interactions with pharmaceuticals than with EDCs. Linear relationships were demonstrated between log-Kcoc and pharmaceutical properties such as log Kow (octanol-water partition coefficient), highlighting the importance of compound hydrophobicity in controlling their binding with colloids. Such a finding is in contrast to that for EDCs whose Kcoc values were independent of their Kow values. The CFUF-LC-MS technique has the potential to become a widely applicable tool for quantifying the distribution of emerging organic pollutants between nanoparticles and the dissolved phase. © 2007 American Chemical Society.	en_US
dc.relation.ispartof	Environmental Science and Technology	en_US
dc.relation.isbasedon	10.1021/es071507d	en_US
dc.subject.classification	Environmental Sciences	en_US
dc.subject.mesh	Pharmaceutical Preparations	en_US
dc.subject.mesh	Colloids	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Ultrafiltration	en_US
dc.subject.mesh	Chromatography, Liquid	en_US
dc.subject.mesh	Kinetics	en_US
dc.subject.mesh	Adsorption	en_US
dc.subject.mesh	Tandem Mass Spectrometry	en_US
dc.title	Assessment of the interaction between aquatic colloids and pharmaceuticals facilitated by cross-flow ultrafiltration	en_US
dc.type	Journal Article
utslib.citation.volume	23	en_US
utslib.citation.volume	41	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access
pubs.issue	23	en_US
pubs.publication-status	Published	en_US
pubs.volume	41	en_US

Abstract:

Interactions between pharmaceuticals and aquatic colloids are a key process regulating their environmental fate, but poorly understood. A validated cross-flow ultrafiltration (CFUF) system was used to isolate river colloids and to determine the partition of selected pharmaceuticals between colloidal (>1 kDa but <0.7 μm) and dissolved phases (<1 kDa) by liquid chromatography-tandem mass spectrometry (LC-MS-MS). The kinetics of pharmaceutical binding to colloids was rapid, reaching equilibrium within 5 min. The mass balance of chosen pharmaceuticals through CFLUF system was satisfactory for propranolol, sulfamethoxazole, meberverine, carbamazepine, indomethacine, diclofenac, and meclofenamic acid. The partition coefficient normalized to colloidal organic carbon content (Kcoc) varied from 5.45 × 104 to 7.54 × 105 mL/g for the chosen pharmaceuticals, which are greater than those for endocrine disrupting chemicals (EDCs), suggesting substantially stronger colloidal interactions with pharmaceuticals than with EDCs. Linear relationships were demonstrated between log-Kcoc and pharmaceutical properties such as log Kow (octanol-water partition coefficient), highlighting the importance of compound hydrophobicity in controlling their binding with colloids. Such a finding is in contrast to that for EDCs whose Kcoc values were independent of their Kow values. The CFUF-LC-MS technique has the potential to become a widely applicable tool for quantifying the distribution of emerging organic pollutants between nanoparticles and the dissolved phase. © 2007 American Chemical Society.

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http://hdl.handle.net/10453/28393